Suchergebnisse

Davis, B.; Backus, K.; Winter, G.; Chica, R.; Li, D.; Lee, S. Y.; He, C.; Weeks, A.; Overall, C.; Hagihara, S. et al.; Thuronyi, B.; Kamat, S.; Chen, L.-L.; Hurtado Guerrero, R.; Yao, S.; Mahal, L. K.; Voigt, C.; Woo, C.; Strauss, E.; Kikuchi, K.; Dore, T.; Radford, S.; Li, X. D.; Heo, W. D.; Superti-Furga, G.; Deans, T.; Belousov, V.; Matthews, M.; Jackson, C.; Malek, S.; Waldmann, H.; Rising, A.; Jewett, M.; Stamou, D.; Parker, E.; Murakami, M.; Polizzi, K.; Hamachi, I.; Erb, T.; Joo, C.; Uesugi, M.; Prinjha, R.; Rechavi, G.; Solano, R.; Schulman, B.; David, Y.; Oslund, R.: Voices of chemical biology. Nature Chemical Biology 17 (1), S. 1 - 4 (2021)

Karayel, O.; Michaelis, A. C.; Mann, M.; Schulman, B. A.; Langlois, C. R.: DIA-based systems biology approach unveils E3 ubiquitin ligase-dependent responses to a metabolic shift. Proceedings of the National Academy of Sciences of the United States of America, 202020197 (2020)

Shin, D.; Mukherjee, R.; Grewe, D.; Bojkova, D.; Baek, K.; Bhattacharya, A.; Schulz, L.; Widera, M.; Mehdipour, A. R.; Tascher, G. et al.; Geurink, P. P.; Wilhelm, A.; van der Heden van Noort, G. J.; Ovaa, H.; Mueller, S.; Knobeloch, K.-P.; Rajalingam, K.; Schulman, B.; Cinatl, J.; Hummer, G.; Ciesek, S.; Dikic, I.: Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature 587, S. 657 - 662 (2020)

Baek, K.; Krist, D. T.; Prabu, J. R.; Hill, S.; Klügel, M.; Neumaier, L.-M.; von Gronau, S.; Kleiger, G.; Schulman, B. A.: NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly. Nature 578, S. 461 - 466 (2020)

Baek, K.; Schulman, B.: Molecular glue concept solidifies. NATURE CHEMICAL BIOLOGY 16 (1), S. 2 - 3 (2020)

Karayel, Ö.; Xu, P.; Bludau, I.; Velan Bhoopalan, S.; Yao, Y.; Ana Rita, F.C.; Santos, A.; Schulman, B. A.; Alpi, A. F.; Weiss, M.J. et al.; Mann, M.: Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis. Molecular Systems Biology 16 (12), e9813 (2020)

Liwocha, J.; Krist, D. T.; van der Heden van Noort, G.J.; Hansen, F. M.; Truong, V.H.; Karayel, O.; Purser, N.; Houston, D.; Burton, N.; Bostock, M.J. et al.; Sattler, M.; Mann, M.; Harrison, J.S.; Kleiger, G.; Ovaa, H.; Schulman, B. A.: Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. Nature Chemical Biology (2020)

Miller-Vedam, L. E.; Bräuning, B.; Popova, K. D.; Oakdale, N. T. S.; Bonnar, J. L.; Prabu, J. R.; Boydston, E. A.; Sevillano, N.; Shurtleff, M. J.; Stroud, R. M. et al.; Craik, C. S.; Schulman, B. A.; Frost, A.; Weissman, J. S.: Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. eLife 9, e62611 (2020)

Neefjes, J.; Overkleeft, H.; Ploegh, H.; Schulman, B.: Obituary Huib Ovaa (1973-2020). CELL CHEMICAL BIOLOGY 27 (6), S. 645 - 646 (2020)

Qiao, S.; Langlois, C. R.; Chrustowicz, J.; Sherpa, D.; Karayel, O.; Hansen, F. M.; Beier, V.; von Gronau, S.; Bollschweiler, D.; Schäfer, T. et al.; Alpi, A. F.; Mann, M.; Prabu, J. R.; Schulman, B.: Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly. MOLECULAR CELL 77 (1), S. 150 - 163.e9 (2020)

Qiu, Y.; Zheng, Y.; Grace, C. R. R.; Liu, X.; Klionsky, D. J.; Schulman, B. A.: Allosteric regulation through a switch element in the autophagy E2, Atg3. AUTOPHAGY 16 (1), S. 183 - 184 (2020)

Richeson, K. V.; Bodrug, T.; Sackton, K. L.; Yamaguchi, M.; Paulo, J. A.; Gygi, S. P.; Schulman, B. A.; Brown, N. G.; King, R. W.: Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C-Cdc20. Nature Chemical Biology 16, S. 546 - 555 (2020)

Sonn-Segev, A.; BelacicD, K.; Bodrug, T.; Youngs, G.; VanderLinden, R. T.; Schulman, B. A.; Schimpf, J.; Friedrich, T.; Phat Dip, V.; Schwartz, T. U. et al.; Bauer, B.; Peters, J.-M.; Struwel, W. B.; Benesch, J. L. P.; Brown, N. G.; Haselbach, D.; Kukura, P.: Quantifying the heterogeneity of macromolecular machines by mass photometry. NATURE COMMUNICATIONS 11 (1) (2020)

Wilfling, F.; Lee, C.-W.; Erdmann, P. S.; Zheng, Y.; Sherpa, D.; Jentsch, S.; Pfander, B.; Schulman, B. A.; Baumeister, W.: A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits. Molecular Cell 80 (5), S. 764 - 778.e7 (2020)

Watson, E. R.; Brown, N. G.; Peters, J. M.; Stark, H.; Schulman, B. A.: Posing the APC/C E3 ubiquitin ligase to orchestrate cell division. Trends in Cell Biology 29 (2), S. 117 - 134 (2019)

Hill, S.; Reichermeier, K.; Scott, D. C.; Samentar, L.; Coulombe-Huntington, J.; Izzi, L.; Tang, X.; Ibarra, R.; Bertomeu, T.; Moradian, A. et al.; Sweredoski, M. J.; Caberoy, N.; Schulman, B. A.; Sicheri, F.; Tyers, M.; Kleiger, G.: Robust cullin-RING ligase function is established by a multiplicity of polyubiquitylation pathways. ELIFE 8, e51163 (2019)

Huttenhain, R.; Xu, J.; Burton, L. A.; Gordon, D. E.; Hultquist, J. F.; Johnson, J. R.; Satkamp, L.; Hiatt, J.; Rhee, D. Y.; Baek, K. et al.; Crosby, D. C.; Frankel, A. D.; Marson, A.; Harper, J. W.; Alpi, A. F.; Schulman, B. A.; Gross, J. D.; Krogan, N. J.: ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Cell Host & Microbe 26 (1), S. 86 - 99.e7 (2019)

Kim, H. S.; Hammill, J. T.; Scott, D. C.; Chen, Y.; Min, J.; Rector, J.; Singh, B.; Schulman, B. A.; Guy, R. K.: Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation. JOURNAL OF MEDICINAL CHEMISTRY 62 (18), S. 8429 - 8442 (2019)

Watson, E. R.; Grace, C. R. R.; Zhang, W.; Miller, D. J.; Davidson, I. F.; Prabu, J. R.; Yu, S.; Bolhuis, D. L.; Kulko, E. T.; Vollrath, R. et al.; Haselbach, D.; Stark, H.; Peters, J.-M.; Brown, N. G.; Sidhu, S. S.; Schulman, B. A.: Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116 (35), S. 17280 - 17289 (2019)

Zheng, Y.; Qiu, Y.; Grace, C. R. R.; Liu, X.; Klionsky, D. J.; Schulman, B. A.: A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade. Nature Communications 10, 3600 (2019)