Suchergebnisse

Baek, K.; Scott, D. C.; Schulman, B. A.: NEDD8 and ubiquitin ligation by cullin-RING E3 ligases. Current Opinion in Structural Biology 67, S. 101 - 109 (2021)

Davis, B.; Backus, K.; Winter, G.; Chica, R.; Li, D.; Lee, S. Y.; He, C.; Weeks, A.; Overall, C.; Hagihara, S. et al.; Thuronyi, B.; Kamat, S.; Chen, L.-L.; Hurtado Guerrero, R.; Yao, S.; Mahal, L. K.; Voigt, C.; Woo, C.; Strauss, E.; Kikuchi, K.; Dore, T.; Radford, S.; Li, X. D.; Heo, W. D.; Superti-Furga, G.; Deans, T.; Belousov, V.; Matthews, M.; Jackson, C.; Malek, S.; Waldmann, H.; Rising, A.; Jewett, M.; Stamou, D.; Parker, E.; Murakami, M.; Polizzi, K.; Hamachi, I.; Erb, T.; Joo, C.; Uesugi, M.; Prinjha, R.; Rechavi, G.; Solano, R.; Schulman, B.; David, Y.; Oslund, R.: Voices of chemical biology. Nature Chemical Biology 17 (1), S. 1 - 4 (2021)

Heider, L.; Eichner, R.; Stroh, J.; Morath, V.; Kuisl, A.; Zecha, J.; Lawatscheck, J.; Baek, K.; Garz, A.-K.; Rudelius, M. et al.; Deuschle, F.-C.; Keller, U.; Lemeer, S.; Verbeek, M.; Gotze, K. S.; Skerra, A.; Weber, W. A.; Buchner, J.; Schulman, B. A.; Kuster, B.; Fernandez-Saiz, V.; Bassermann, F.: The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma. Molecular Cell 81 (6), S. 1170 - 1186.e10 (2021)

Horn-Ghetko, D.; Krist, D. T.; Prabu, J. R.; Baek, K.; Mulder, M. P. C.; Kluegel, M.; Scott, D. C.; Ovaa, H.; Kleiger, G.; Schulman, B.: Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. NATURE 590 (7847) (2021)

Kim, H. S.; Hammill, J. T.; Scott, D. C.; Chen, Y.; Rice, A. L.; Pistel, W.; Singh, B.; Schulman, B. A.; Guy, R. K.: Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M. Journal of Medicinal Chemistry 64 (9), S. 5850 - 5862 (2021)

Schulman, B. A.; Harper, J. W.: Cell biology Host ubiquitin protein tags lipid to fight bacteria. Nature 594 (7861), S. 28 - 29 (2021)

Sherpa, D.; Chrustowicz, J.; Qiao, S.; Langlois, C. R.; Hehl, L. A.; Gottemukkala, K. V.; Hansen, F. M.; Karayel, O.; von Gronau, S.; Prabu, J. R. et al.; Mann, M.; Alpi, A. F.; Schulman, B. A.: GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Molecular Cell 81 (11), S. 2445 - 2459.e13 (2021)

Xu, P.; Scott, D. C.; Xu, B.; Yao, Y.; Feng, R.; Cheng, L.; Mayberry, K.; Wang, Y.-D.; Bi, W.; Palmer, L. E. et al.; King, M. T.; Wang, H.; Li, Y.; Fan, Y.; Alpi, A. F.; Li, C.; Peng, J.; Papizan, J.; Pruett-Miller, S. M.; Spallek, R.; Bassermann, F.; Cheng, Y.; Schulman, B.; Weiss, M. J.: FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis. Blood 137, S. 155 - 167 (2021)

Karayel, O.; Michaelis, A. C.; Mann, M.; Schulman, B. A.; Langlois, C. R.: DIA-based systems biology approach unveils E3 ubiquitin ligase-dependent responses to a metabolic shift. Proceedings of the National Academy of Sciences of the United States of America, 202020197 (2020)

Shin, D.; Mukherjee, R.; Grewe, D.; Bojkova, D.; Baek, K.; Bhattacharya, A.; Schulz, L.; Widera, M.; Mehdipour, A. R.; Tascher, G. et al.; Geurink, P. P.; Wilhelm, A.; van der Heden van Noort, G. J.; Ovaa, H.; Mueller, S.; Knobeloch, K.-P.; Rajalingam, K.; Schulman, B.; Cinatl, J.; Hummer, G.; Ciesek, S.; Dikic, I.: Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature 587, S. 657 - 662 (2020)

Baek, K.; Krist, D. T.; Prabu, J. R.; Hill, S.; Klügel, M.; Neumaier, L.-M.; von Gronau, S.; Kleiger, G.; Schulman, B. A.: NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly. Nature 578, S. 461 - 466 (2020)

Baek, K.; Schulman, B.: Molecular glue concept solidifies. NATURE CHEMICAL BIOLOGY 16 (1), S. 2 - 3 (2020)

Karayel, Ö.; Xu, P.; Bludau, I.; Velan Bhoopalan, S.; Yao, Y.; Ana Rita, F.C.; Santos, A.; Schulman, B. A.; Alpi, A. F.; Weiss, M.J. et al.; Mann, M.: Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis. Molecular Systems Biology 16 (12), e9813 (2020)

Liwocha, J.; Krist, D. T.; van der Heden van Noort, G.J.; Hansen, F. M.; Truong, V.H.; Karayel, O.; Purser, N.; Houston, D.; Burton, N.; Bostock, M.J. et al.; Sattler, M.; Mann, M.; Harrison, J.S.; Kleiger, G.; Ovaa, H.; Schulman, B. A.: Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. Nature Chemical Biology (2020)

Miller-Vedam, L. E.; Bräuning, B.; Popova, K. D.; Oakdale, N. T. S.; Bonnar, J. L.; Prabu, J. R.; Boydston, E. A.; Sevillano, N.; Shurtleff, M. J.; Stroud, R. M. et al.; Craik, C. S.; Schulman, B. A.; Frost, A.; Weissman, J. S.: Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. eLife 9, e62611 (2020)

Neefjes, J.; Overkleeft, H.; Ploegh, H.; Schulman, B.: Obituary Huib Ovaa (1973-2020). CELL CHEMICAL BIOLOGY 27 (6), S. 645 - 646 (2020)

Qiao, S.; Langlois, C. R.; Chrustowicz, J.; Sherpa, D.; Karayel, O.; Hansen, F. M.; Beier, V.; von Gronau, S.; Bollschweiler, D.; Schäfer, T. et al.; Alpi, A. F.; Mann, M.; Prabu, J. R.; Schulman, B.: Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly. MOLECULAR CELL 77 (1), S. 150 - 163.e9 (2020)

Qiu, Y.; Zheng, Y.; Grace, C. R. R.; Liu, X.; Klionsky, D. J.; Schulman, B. A.: Allosteric regulation through a switch element in the autophagy E2, Atg3. AUTOPHAGY 16 (1), S. 183 - 184 (2020)

Richeson, K. V.; Bodrug, T.; Sackton, K. L.; Yamaguchi, M.; Paulo, J. A.; Gygi, S. P.; Schulman, B. A.; Brown, N. G.; King, R. W.: Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C-Cdc20. Nature Chemical Biology 16, S. 546 - 555 (2020)

Sonn-Segev, A.; BelacicD, K.; Bodrug, T.; Youngs, G.; VanderLinden, R. T.; Schulman, B. A.; Schimpf, J.; Friedrich, T.; Phat Dip, V.; Schwartz, T. U. et al.; Bauer, B.; Peters, J.-M.; Struwel, W. B.; Benesch, J. L. P.; Brown, N. G.; Haselbach, D.; Kukura, P.: Quantifying the heterogeneity of macromolecular machines by mass photometry. NATURE COMMUNICATIONS 11 (1) (2020)