Publikationen von Anna Czarna

Pustelny, K.; Zdzalik, M.; Stach, N.; Stec-Niemczyk, J.; Cichon, P.; Czarna, A.; Popowicz, G.; Mak, P.; Drag, M.; Salvesen, G. S. et al.; Wladyka, B.; Potempa, J.; Dubin, A.; Dubin, G.: Staphylococcal SplB Serine Protease Utilizes a Novel Molecular Mechanism of Activation. JOURNAL OF BIOLOGICAL CHEMISTRY 289 (22), S. 15544 - 15553 (2014)

Czarna, A.; Berndt, A.; Singh, H. R.; Grudziecki, A.; Ladurner, A. G.; Timinszky, G.; Kramer, A.; Wolf, E.: Structures of Drosophila Cryptochrome and Mouse Cryptochrome1 Provide Insight into Circadian Function. CELL 153 (6), S. 1394 - 1405 (2013)

Czarna, A.; Breitkreuz, H.; Mahrenholz, C. C.; Arens, J.; Strauss, H. M.; Wolf, E.: Quantitative Analyses of Cryptochrome-mBMAL1 Interactions MECHANISTIC INSIGHTS INTO THE TRANSCRIPTIONAL REGULATION OF THE MAMMALIAN CIRCADIAN CLOCK. Journal of Biological Chemistry 286 (25), S. 22414 - 22425 (2011)

Popowicz, G. M.; Czarna, A.; Wolf, S.; Wang, K.; Wang, W.; Domling, A.; Holak, T. A.: Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. Cell Cycle 9 (6), S. 1104 - 1111 (2010)

Czarna, A.; Beck, B.; Srivastava, S.; Popowicz, G. M.; Wolf, S.; Huang, Y. J.; Bista, M.; Holak, T. A.; Domling, A.: Robust Generation of Lead Compounds for Protein-Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists. Angewandte Chemie-International Edition 49 (31), S. 5352 - 5356 (2010)

Srivastava, S.; Beck, B.; Wang, W.; Czarna, A.; Holak, T. A.; Dömling, A.: Rapid and Efficient Hydrophilicity Tuning of p53/mdm2 Antagonists. Journal of Combinatorial Chemistry 11 (4), S. 631 - 639 (2009)

Czarna, A.; Popowicz, G. M.; Pecak, A.; Wolf, S.; Dubin, G.; Holak, T. A.: High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle 8 (8), S. 1176 - 1184 (2009)

Rothweiler, U.; Czarna, A.; Weber, L.; Popowicz, G. M.; Brongel, K.; Kowalska, K.; Orth, M.; Stemmann, O.; Holak, T. A.: NMR screening for lead compounds using tryptophan-mutated proteins. Journal of Medicinal Chemistry 51 (16), S. 5035 - 5042 (2008)

Popowicz, G. M.; Czarna, A.; Holak, T. A.: Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. Cell Cycle 7 (15), S. 2441 - 2443 (2008)

Rothweiler, U.; Czarna, A.; Krajewski, M.; Ciombor, J.; Kalinski, C.; Khazak, V.; Ross, G.; Skobeleva, N.; Weber, L.; Holak, T. A.: Isoquinolin-1-one inhibitors of the MDM2-p53 interaction. ChemMedChem 3 (7), S. 1118 - 1128 (2008)

Dubin, G.; Stec-Niemczyk, J.; Kisielewska, M.; Pustelny, K.; Popowicz, G. M.; Bista, M.; Kantyka, T.; Boulware, K. T.; Stennicke, H. R.; Czarna, A. et al.; Phopaisarn, M.; Daugherty, P. S.; Thogersen, I. B.; Enghild, J. J.; Thornberry, N.; Dubin, A.; Potempa, J.: Enzymatic activity of the Staphylococcus aureus SpIB serine protease is induced by substrates containing the sequence Trp-Glu-Leu-Gin. Journal of Molecular Biology 379 (2), S. 343 - 356 (2008)

Popowicz, G. M.; Czarna, A.; Rothweiler, U.; Szwagierczak, A.; Krajewski, M.; Weber, L.; Holak, T. A.: Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle 6 (19), S. 2386 - 2392 (2007)

Czarna, A.: Molecular basis for the inhibition of p53 by Mdmx and Mdm2. Dissertation, Technische Universität, München (2009)