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Zeitschriftenartikel (78)

21.
Zeitschriftenartikel
Khoury, K.; Popowicz, G. M.; Holak, T. A.; Domling, A.: The p53-MDM2/MDMX axis - A chemotype perspective. Medchemcomm 2 (4), S. 246 - 260 (2011)
22.
Zeitschriftenartikel
Popowicz, G. M.; Domling, A.; Holak, T. A.: The Structure-Based Design of Mdm2/Mdmx-p53 Inhibitors Gets Serious. Angewandte Chemie-International Edition 50 (12), S. 2680 - 2688 (2011)
23.
Zeitschriftenartikel
Huang, Y. J.; Wolf, S.; Bista, M.; Meireles, L.; Camacho, C.; Holak, T. A.; Domling, A.: 1,4-Thienodiazepine-2,5-diones via MCR (I): Synthesis, Virtual Space and p53-Mdm2 Activity. Chemical Biology & Drug Design 76 (2), S. 116 - 129 (2010)
24.
Zeitschriftenartikel
Ducka, A. M.; Joel, P.; Popowicz, G. M.; Trybus, K. M.; Schleicher, M.; Noegel, A. A.; Huber, R.; Holak, T. A.; Sitar, T.: Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proceedings of the National Academy of Sciences of the United States of America 107 (26), S. 11757 - 11762 (2010)
25.
Zeitschriftenartikel
Popowicz, G. M.; Czarna, A.; Wolf, S.; Wang, K.; Wang, W.; Domling, A.; Holak, T. A.: Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. Cell Cycle 9 (6), S. 1104 - 1111 (2010)
26.
Zeitschriftenartikel
Czarna, A.; Beck, B.; Srivastava, S.; Popowicz, G. M.; Wolf, S.; Huang, Y. J.; Bista, M.; Holak, T. A.; Domling, A.: Robust Generation of Lead Compounds for Protein-Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists. Angewandte Chemie-International Edition 49 (31), S. 5352 - 5356 (2010)
27.
Zeitschriftenartikel
Szwagierczak, A.; Antonenka, U.; Popowicz, G. M.; Sitar, T.; Holak, T. A.; Rakin, A.: Structures of the Arm-type Binding Domains of HPI and HAI7 Integrases. Journal of Biological Chemistry 284 (46), S. 31664 - 31671 (2009)
28.
Zeitschriftenartikel
Srivastava, S.; Beck, B.; Wang, W.; Czarna, A.; Holak, T. A.; Dömling, A.: Rapid and Efficient Hydrophilicity Tuning of p53/mdm2 Antagonists. Journal of Combinatorial Chemistry 11 (4), S. 631 - 639 (2009)
29.
Zeitschriftenartikel
Bista, M.; Kowalska, K.; Janczyk, W.; Dömling, A.; Holak, T. A.: Robust NMR Screening for Lead Compounds Using Tryptophan-Containing Proteins. Journal of the American Chemical Society 131 (22), S. 7500 - 7501 (2009)
30.
Zeitschriftenartikel
Czarna, A.; Popowicz, G. M.; Pecak, A.; Wolf, S.; Dubin, G.; Holak, T. A.: High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle 8 (8), S. 1176 - 1184 (2009)
31.
Zeitschriftenartikel
Zuckerman, V.; Lenos, K.; Popowicz, G. M.; Silberman, I.; Grossman, T.; Marine, J. C.; Holak, T. A.; Jochemsen, A. G.; Haupt, Y.: c-Abl Phosphorylates Hdmx and Regulates Its Interaction with p53. Journal of Biological Chemistry 284 (6), S. 4031 - 4039 (2009)
32.
Zeitschriftenartikel
Rothweiler, U.; Czarna, A.; Weber, L.; Popowicz, G. M.; Brongel, K.; Kowalska, K.; Orth, M.; Stemmann, O.; Holak, T. A.: NMR screening for lead compounds using tryptophan-mutated proteins. Journal of Medicinal Chemistry 51 (16), S. 5035 - 5042 (2008)
33.
Zeitschriftenartikel
Popowicz, G. M.; Czarna, A.; Holak, T. A.: Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. Cell Cycle 7 (15), S. 2441 - 2443 (2008)
34.
Zeitschriftenartikel
Riedl, J.; Crevenna, A. H.; Kessenbrock, K.; Yu, J. H.; Neukirchen, D.; Bista, M.; Bradke, F.; Jenne, D.; Holak, T. A.; Werb, Z. et al.; Sixt, M.; Wedlich-Söldner, R.: Lifeact: a versatile marker to visualize F-actin. Nature Methods 5 (7), S. 605 - 607 (2008)
35.
Zeitschriftenartikel
Rothweiler, U.; Czarna, A.; Krajewski, M.; Ciombor, J.; Kalinski, C.; Khazak, V.; Ross, G.; Skobeleva, N.; Weber, L.; Holak, T. A.: Isoquinolin-1-one inhibitors of the MDM2-p53 interaction. ChemMedChem 3 (7), S. 1118 - 1128 (2008)
36.
Zeitschriftenartikel
Peche, V.; Shekar, S.; Leichter, M.; Korte, H.; Schroder, R.; Schleicher, M.; Holak, T. A.; Clemen, C. S.; Ramanath-Y, B.; Pfitzer, G. et al.; Karakesisoglou, I.; Noegel, A. A.: CAP2, cyclase-associated protein 2, is a dual compartment protein. Cellular and Molecular Life Sciences 64 (19-20), S. 2702 - 2715 (2007)
37.
Zeitschriftenartikel
Popowicz, G. M.; Czarna, A.; Rothweiler, U.; Szwagierczak, A.; Krajewski, M.; Weber, L.; Holak, T. A.: Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle 6 (19), S. 2386 - 2392 (2007)
38.
Zeitschriftenartikel
Smialowski, P.; Martin-Galiano, A. J.; Mikolajka, A.; Girschick, T.; Holak, T. A.; Frishman, D.: Protein solubility: sequence based prediction and experimental verification. Bioinformatics 23 (19), S. 2536 - 2542 (2007)
39.
Zeitschriftenartikel
Krajewski, M.; Rothweiler, U.; D'Silva, L.; Majumdar, S.; Klein, C.; Holak, T. A.: An NMR-Based antagonist induced dissociation assay for targeting the ligand-protein and protein-protein interactions in competition binding experiments. Journal of Medicinal Chemistry 50 (18), S. 4382 - 4387 (2007)
40.
Zeitschriftenartikel
Singh, M.; Popowicz, G. M.; Krajewski, M.; Holak, T. A.: Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex. ChemBioChem 8 (11), S. 1308 - 1316 (2007)
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