Publications of O. Karayel

Journal Article (18)

Journal Article
Qiao, S.; Lee, C.-W.; Sherpa, D.; Chrustowicz, J.; Cheng, J. D.; Duennebacke, M.; Steigenberger, B.; Karayel, O.; Tung Vu, D.; Gronau, S. v. et al.; Mann, M.; Wilfling, F.; Schulman, B.: Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation. Nature Communications 13 (1), 3041 (2022)
Journal Article
Langlois, C. R.; Beier, V.; Karayel, O.; Chrustowicz, J.; Sherpa, D.; Mann, M.; Schulman, B. A.: A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters. EMBO Reports 23, e53835 (2022)
Journal Article
Kutzner, K.; Woods, S.; Karayel, O.; Gehring, T.; Yin, H.; Flatley, A.; Grass, C.; Wimberger, N.; Tofaute, M. J.; Seeholzer, T. et al.; Feederle, R.; Mann, M.; Krappmann, D.: Phosphorylation of serine-893 in CARD11 suppresses the formation and activity of the CARD11-BCL10-MALT1 complex in T and B cells. Science Signaling 15 (723), eabk3083 (2022)
Journal Article
Steger, M.; Karayel, Ö.; Demichev, V.: Ubiquitinomics: History, methods, and applications in basic research and drug discovery. Proteomics, e2200074 (2022)
Journal Article
Yin, H.; Karayel, O.; Chao, Y.-Y.; Seeholzer, T.; Hamp, I.; Plettenburg, O.; Gehring, T.; Zielinski, C.; Mann, M.; Krappmann, D.: A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-kappa B signaling in activated T cells. Cellular and Molecular Life Sciences 79 (2), 112 (2022)
Journal Article
Hansen, F. M.; Tanzer, M. C.; Brüning, F.; Bludau, I.; Stafford, C.; Schulman, B. A.; Robles, M. S.; Karayel, O.; Mann, M.: Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology. Nature Communications 12 (1), 254 (2021)
Journal Article
Liwocha, J.; Krist, D. T.; van der Heden van Noort, G.J.; Hansen, F. M.; Truong, V.H.; Karayel, O.; Purser, N.; Houston, D.; Burton, N.; Bostock, M.J. et al.; Sattler, M.; Mann, M.; Harrison, J.S.; Kleiger, G.; Ovaa, H.; Schulman, B. A.: Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. Nature Chemical Biology 17, pp. 272 - 279 (2021)
Journal Article
Sherpa, D.; Chrustowicz, J.; Qiao, S.; Langlois, C. R.; Hehl, L. A.; Gottemukkala, K. V.; Hansen, F. M.; Karayel, O.; von Gronau, S.; Prabu, J. R. et al.; Mann, M.; Alpi, A. F.; Schulman, B. A.: GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Molecular Cell 81 (11), pp. 2445 - 2459.e13 (2021)
Journal Article
Stukalov, A.; Girault, V.; Grass, V.; Karayel, O.; Bergant, V.; Urban, C.; Haas, D. A.; Huang, Y.; Oubraham, L.; Wang, A. et al.; Hamad, M. S.; Piras, A.; Hansen, F. M.; Tanzer, M. C.; Paron, I.; Zinzula, L.; Engleitner, T.; Reinecke, M.; Lavacca, T. M.; Ehmann, R.; Woelfel, R.; Jores, J.; Kuster, B.; Protzer, U.; Rad, R.; Ziebuhr, J.; Thiel, V.; Scaturro, P.; Mann, M.; Pichlmair, A.: Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature 594 (7862), pp. 246 - 252 (2021)
Journal Article
Virreira-Winter, S.; Karayel, O.; Strauss, M. T.; Padmanabhan, S.; Surface, M.; Merchant, K.; Alcalay, R. N.; Mann, M.: Urinary proteome profiling for stratifying patients with familial Parkinson's disease. Embo Molecular Medicine 13 (3), e13257 (2021)
Journal Article
Karayel, O.; Michaelis, A. C.; Mann, M.; Schulman, B. A.; Langlois, C. R.: DIA-based systems biology approach unveils E3 ubiquitin ligase-dependent responses to a metabolic shift. Proceedings of the National Academy of Sciences of the United States of America 117 (51), 202020197 (2020)
Journal Article
Karayel, Ö.; Tonelli, F.; Virreira Winter, S.; Geyer, P. E.; Fan, Y.; Sammler, E. M.; Alessi, D. R.; Steger, M.; Mann, M.: Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease. Molecular and Cellular Proteomics 19 (9), pp. 1546 - 1560 (2020)
Journal Article
Karayel, Ö.; Xu, P.; Bludau, I.; Velan Bhoopalan, S.; Yao, Y.; Ana Rita, F.C.; Santos, A.; Schulman, B. A.; Alpi, A. F.; Weiss, M.J. et al.; Mann, M.: Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis. Molecular Systems Biology 16 (12), e9813 (2020)
Journal Article
Qiao, S.; Langlois, C. R.; Chrustowicz, J.; Sherpa, D.; Karayel, O.; Hansen, F. M.; Beier, V.; von Gronau, S.; Bollschweiler, D.; Schäfer, T. et al.; Alpi, A. F.; Mann, M.; Prabu, J. R.; Schulman, B.: Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly. MOLECULAR CELL 77 (1), pp. 150 - 163.e9 (2020)
Journal Article
Gehring, T.; Erdmann, T.; Rahm, M.; Gras, C.; Flatley, A.; O'Neill, T. J.; Woods, S.; Meininger, I.; Karayel, O.; Kutzner, K. et al.; Grau, M.; Shinohara, H.; Lammens, K.; Feederle, R.; Hauck, S. M.; Lenz, G.; Krappmann, D.: MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells. CELL REPORTS 29 (4), pp. 873 - 888 (2019)
Journal Article
Ageta, H.; Ageta-Ishihara, N.; Hitachi, K.; Karayel, O.; Onouchi, T.; Yamaguchi, H.; Kahyo, T.; Hatanaka, K.; Ikegami, K.; Yoshioka, Y. et al.; Nakamura, K.; Kosaka, N.; Nakatani, M.; Uezumi, A.; Ide, T.; Tsutsumi, Y.; Sugimura, H.; Kinoshita, M.; Ochiya, T.; Mann, M.; Setou, M.; Tsuchida, K.: UBL3 modification influences protein sorting to small extracellular vesicles. Nature Communications 9, 3936 (2018)
Journal Article
Humphrey, S. J.; Karayel, O.; James, D. E.; Mann, M.: High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform. Nature Protocols 13 (9), pp. 1897 - 1916 (2018)
Journal Article
Steger, M.; Diez, F.; Dhekne, H. S.; Lis, P.; Nirujogi, R. S.; Karayel, O.; Tonelli, F.; Martinez, T. N.; Lorentzen, E.; Pfeffer, S. R. et al.; Alessi, D. R.; Mann, M.: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. eLife 6, e31012 (2017)

Meeting Abstract (1)

Meeting Abstract
Langlois, C. R.; Qiao, S.; Sherpa, D.; Chrustowicz, J.; Beier, V.; Karayel, O.; Schulman, B.: The GID E3 Ubiquitin Ligase Converts Between Anticipatory and Active States Through the Incorporation of Swappable Substrate Receptors. In The FASEB Journal, 34, p. 1 - 1. Annual Meeting on Experimental Biology, San Diego, CA, April 04, 2020 - April 07, 2020. The Federation, Bethesda, Md. (2020)

Thesis - PhD (1)

Thesis - PhD
Karayel, Ö.: Development of sensitive and quantitative proteomics strategies to study phospho- and ubiquitin-signaling in health and disease. Dissertation, LMU München, Fakultät für Chemie und Pharmazie (2020)
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