This project explores the mostly uncharted area of alternative phase contrast methods for TEM. In particular, the development and applications of thin film phase plates and the associated hardware and software. [more]
We are interested in the molecular organization of actin structures in their native environment, and how it enables actin filaments to exert or resist against forces. [more]
The 26S proteasome is 2.6 MDa multisubunits protease responsible for the regulated degradation of polyubiquitylated proteins. To understand how the 26S proteasome executes its function, we take a multidisciplinary approach combining cryo-EM single particle analysis with biochemical and computational studies. [more]
We study the structural mechanisms by which protein aggregation can be toxic to cells, leading to neurodegenerative diseases such as Alzheimer’s or Parkinson’s. [more]
Synapses are functional connection points between neurons, transmitting a presynaptic electrical signal (action potential) to the postsynaptic neuron. We use cryo-electron tomography to reveal the architecture of complexes involved in synaptic transmission and to obtain more information about their function. [more]

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