Publications of Brenda A. Schulman

Baek, K.; Krist, D. T.; Prabu, J. R.; Hill, S.; Klügel, M.; Neumaier, L.-M.; von Gronau, S.; Kleiger, G.; Schulman, B. A.: NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly. Nature 578, pp. 461 - 466 (2020)

Baek, K.; Schulman, B.: Molecular glue concept solidifies. NATURE CHEMICAL BIOLOGY 16 (1), pp. 2 - 3 (2020)

Karayel, Ö.; Xu, P.; Bludau, I.; Velan Bhoopalan, S.; Yao, Y.; Ana Rita, F.C.; Santos, A.; Schulman, B. A.; Alpi, A. F.; Weiss, M.J. et al.; Mann, M.: Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis. Molecular Systems Biology 16 (12), e9813 (2020)

Miller-Vedam, L. E.; Bräuning, B.; Popova, K. D.; Oakdale, N. T. S.; Bonnar, J. L.; Prabu, J. R.; Boydston, E. A.; Sevillano, N.; Shurtleff, M. J.; Stroud, R. M. et al.; Craik, C. S.; Schulman, B. A.; Frost, A.; Weissman, J. S.: Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. eLife 9, e62611 (2020)

Neefjes, J.; Overkleeft, H.; Ploegh, H.; Schulman, B.: Obituary Huib Ovaa (1973-2020). CELL CHEMICAL BIOLOGY 27 (6), pp. 645 - 646 (2020)

Qiao, S.; Langlois, C. R.; Chrustowicz, J.; Sherpa, D.; Karayel, O.; Hansen, F. M.; Beier, V.; von Gronau, S.; Bollschweiler, D.; Schäfer, T. et al.; Alpi, A. F.; Mann, M.; Prabu, J. R.; Schulman, B.: Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly. MOLECULAR CELL 77 (1), pp. 150 - 163.e9 (2020)

Qiu, Y.; Zheng, Y.; Grace, C. R. R.; Liu, X.; Klionsky, D. J.; Schulman, B. A.: Allosteric regulation through a switch element in the autophagy E2, Atg3. AUTOPHAGY 16 (1), pp. 183 - 184 (2020)

Richeson, K. V.; Bodrug, T.; Sackton, K. L.; Yamaguchi, M.; Paulo, J. A.; Gygi, S. P.; Schulman, B. A.; Brown, N. G.; King, R. W.: Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C-Cdc20. Nature Chemical Biology 16, pp. 546 - 555 (2020)

Sonn-Segev, A.; BelacicD, K.; Bodrug, T.; Youngs, G.; VanderLinden, R. T.; Schulman, B. A.; Schimpf, J.; Friedrich, T.; Phat Dip, V.; Schwartz, T. U. et al.; Bauer, B.; Peters, J.-M.; Struwel, W. B.; Benesch, J. L. P.; Brown, N. G.; Haselbach, D.; Kukura, P.: Quantifying the heterogeneity of macromolecular machines by mass photometry. NATURE COMMUNICATIONS 11 (1), 1772 (2020)

Wilfling, F.; Lee, C.-W.; Erdmann, P. S.; Zheng, Y.; Sherpa, D.; Jentsch, S.; Pfander, B.; Schulman, B. A.; Baumeister, W.: A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits. Molecular Cell 80 (5), pp. 764 - 778.e7 (2020)

Watson, E. R.; Brown, N. G.; Peters, J. M.; Stark, H.; Schulman, B. A.: Posing the APC/C E3 ubiquitin ligase to orchestrate cell division. Trends in Cell Biology 29 (2), pp. 117 - 134 (2019)

Hill, S.; Reichermeier, K.; Scott, D. C.; Samentar, L.; Coulombe-Huntington, J.; Izzi, L.; Tang, X.; Ibarra, R.; Bertomeu, T.; Moradian, A. et al.; Sweredoski, M. J.; Caberoy, N.; Schulman, B. A.; Sicheri, F.; Tyers, M.; Kleiger, G.: Robust cullin-RING ligase function is established by a multiplicity of polyubiquitylation pathways. ELIFE 8, e51163 (2019)

Huttenhain, R.; Xu, J.; Burton, L. A.; Gordon, D. E.; Hultquist, J. F.; Johnson, J. R.; Satkamp, L.; Hiatt, J.; Rhee, D. Y.; Baek, K. et al.; Crosby, D. C.; Frankel, A. D.; Marson, A.; Harper, J. W.; Alpi, A. F.; Schulman, B. A.; Gross, J. D.; Krogan, N. J.: ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Cell Host & Microbe 26 (1), pp. 86 - 99.e7 (2019)

Kim, H. S.; Hammill, J. T.; Scott, D. C.; Chen, Y.; Min, J.; Rector, J.; Singh, B.; Schulman, B. A.; Guy, R. K.: Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation. JOURNAL OF MEDICINAL CHEMISTRY 62 (18), pp. 8429 - 8442 (2019)

Watson, E. R.; Grace, C. R. R.; Zhang, W.; Miller, D. J.; Davidson, I. F.; Prabu, J. R.; Yu, S.; Bolhuis, D. L.; Kulko, E. T.; Vollrath, R. et al.; Haselbach, D.; Stark, H.; Peters, J.-M.; Brown, N. G.; Sidhu, S. S.; Schulman, B. A.: Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proceedings of the National Academy of Sciences of the United States of America 116 (35), pp. 17280 - 17289 (2019)

Zheng, Y.; Qiu, Y.; Grace, C. R. R.; Liu, X.; Klionsky, D. J.; Schulman, B. A.: A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade. Nature Communications 10, 3600 (2019)

Scott, D. C.; Schulman, B. A.: SCF E3 Ligase Substrates Switch from CAN-D to Can-ubiquitylate. Molecular Cell 69 (5), pp. 721 - 723 (2018)

Bouchard, J. J.; Otero, J. H.; Scott, D. C.; Szulc, E.; Martin, E. W.; Sabri, N.; Granata, D.; Marzahn, M. R.; Lindorff-Larsen, K.; Salvatella, X. et al.; Schulman, B. A.; Mittag, T.: Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments. Molecular Cell 72 (1), pp. 19 - 36.e8 (2018)

Harper, J. W.; Schulman, B. A.: Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis. In: Annual Review of Biochemistry, Vol 90, 2021, pp. 403 - 429 (2021)

Krist, D. T.; Schulman, B.: E3-mediated ubiquitin and ubiquitin-like protein ligation: Mechanisms and chemical probes. In: PROTEIN DEGRADATION WITH NEW CHEMICAL MODALITIES: Successful Strategies in Drug Discovery and Chemical Biology, pp. 184 - 211 (Eds. Weinmann, H.; Crews, C.). Royal Society of Chemistry, London (2021)