Research Group Mechanisms of Protein Biogenesis
Molecular Cell Biology, Protein Biogenesis, Translation regulation, Systems Biology
Proteins mediate most biological processes and function only after folding into complex three-dimensional shapes. To ensure protein homeostasis in a range of environments, cells rely on a complex molecular network that orchestrates timely and accurate protein synthesis, folding, and degradation. Metazoans present unique challenges to this network, as they consist of cells with highly diverse morphology and function, and thus very distinct proteomes. Our research seeks to define how distinct metazoan cell proteomes are established and maintained, and to uncover why some cell types are selectively vulnerable to proteome damage. We address these questions at a systems level using genome-wide assays and gene inactivation screens in stem cell-derived models.