Danny Nedialkova

Danny Nedialkova

Research Group "Mechanisms of Protein Biogenesis"

RNA Biology; Translation Dynamics; Protein Folding; Systems Biology

Proteins mediate most biological processes and function only after folding into complex three-dimensional shapes. To ensure protein homeostasis in a range of environments, cells rely on a complex molecular network that orchestrates timely and accurate protein synthesis, folding, and degradation. Metazoans present unique challenges to this network, as they consist of cells with highly diverse morphology and function, and thus very distinct proteomes. Our research seeks to define how distinct metazoan cell proteomes are established and maintained, and to uncover why some cell types are selectively vulnerable to proteome damage. We address these questions at a systems level using genome-wide assays and gene inactivation screens in stem cell-derived models.

 

Research Overview
Maintaining protein homeostasis (proteostasis) requires the concerted action of sophisticated molecular pathways and assemblies within cells. Proteostasis regulation begins with ribosomes, which ensure the faithful translation of the genetic code by pairing each mRNA codon with the correct amino acid through a matching tRNA. more
Go to Editor View