Press Page Danny Nedialkova

Proteins need to adopt diverse and complex three-dimensional structures in order to function. Loss of protein conformation is catastrophic for cellular health and a hallmark of aging and diverse neurological diseases. As proteins begin to fold upon emergence from translating ribosomes, our aim is to understand how the cell as a system coordinates translation with protein structure acquisition.

We combine in vivo measurements of translation dynamics by ribosome profiling with proteomics, genetics, and biochemistry to define how translation rates guide the attainment of native protein folds in diverse cell types and organisms. Using systems biology approaches, we seek to understand how the cellular machineries for protein synthesis and folding synergize to maintain homeostasis in distinct environments, and how this synergy is perturbed in disease.


How human transfer RNAs are made

Researchers led by Danny Nedialkova at the MPI of Biochemistry discover the mechanisms regulating tRNA expression in human cells, enabling the targeted development of tRNA-based drugs. more

Danny Nedialkova selected as EMBO Young Investigator

RNA biologist Danny Nedialkova from the MPI of Biochemistry has been elected into the EMBO Young Investigator Programme for four years starting in January 2022.

Measuring the (tRNA) world by mim-tRNAseq

Researchers at the Max Planck Institute (MPI) of Biochemistry have developed a method to quantify transfer RNAs and study their modifications in cells from diverse organisms more

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