Press Page Brenda Schulman

The department of Molecular Machines and Signaling was established in July 2017. We focus on understanding how ubiquitin (UB) and UB-like protein modifications direct extraordinary changes in the fates of their targets, such as altering stability, subcellular localization, interactions, or conformation.

The vision for the department is to combine biochemical reconstitution, structure, enzymology, chemistry, protein design, cell biology and genetics – along with other cutting-edge technologies in collaboration with close colleagues (Especially in neighboring departments) – in an integrated and circular process, with continuous flow of information between methodologies.


How cells sort their trash

In an interview with Brenda Schulman, Director at the MPI of Biochemistry, we talked about the findings of her team's recent study and why she dedicated her life to research. more

New "radar" detects active cellular destroyers

Researchers at the Max Planck Institute (MPI) of Biochemistry and the University of Waterloo developed a method, which could facilitate development of new "degrader" therapies that harness the power… more

Rock'n'roll mechanism helps to target proteins for degradation

MPIB researchers discovered a mechanism that recycles protein modules to enable targeted degradation of unwanted proteins and thus avoid problems in the cellular supply chain. more

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