Brenda Schulman
Research Department Molecular Machines and Signaling (MoMaS)
Structural Biology, Ubiquitin Proteasome System, Ubiquitin-like Protein
An important form of regulation is the modification of proteins and membranes by linking them to the small protein ubiquitin or structurally related ubiquitin-like proteins (UBLs). Ubiquitin and UBLs control timing, subcellular location, composition, conformation and activity of thousands of different proteins and macromolecules. In addition, defects in ubiquitin and UBL pathways are associated with numerous diseases such as cancer, neurodegenerative disorders and viral infections. Brenda Schulman's Department “Molecular Machines and Signaling” has shown that hundreds of microscopic, dynamic, multiprotein molecular machines are transiently transformed into different conformations by specialized regulatory factors to control ubiquitin and UBLs in order to regulate virtually all aspects of cell biology.
A widespread mechanism regulating the functions of eukaryotic proteins involves post-translational modification by the small protein ubiquitin (UB) or structurally related ubiquitin-like proteins (UBLs).
more
Department News
We're sad to bid farewell to Arno as he embarks on his new adventure as Senior Lecturer in Edinburgh, but we're taking comfort in the fact that he'll remain a close collaborator and friend. We'll miss Arno, but we're excited to see the great things he'll achieve in his new role.
Gary's summer sabbatical with us has come to an end. We're grateful for the time he spent with our team and look forward to his return.
Happy 25th anniversary, Judith! We're truly privileged to have you in the team!
Brenda gave a talk titled “WDR26 and the GID complex” at the SKDEAS Family Meeting.
Every two years, families, researchers, and supporters from around the globe come together to share, learn, and inspire toward understanding and advocating for Skraban-Deardorff Syndrome.
more
