Brenda Schulman
Research Department Molecular Machines and Signaling (MoMaS)
Structural Biology, Ubiquitin Proteasome System, Ubiquitin-like Protein
An important form of regulation is the modification of proteins and membranes by linking them to the small protein ubiquitin or structurally related ubiquitin-like proteins (UBLs). Ubiquitin and UBLs control timing, subcellular location, composition, conformation and activity of thousands of different proteins and macromolecules. In addition, defects in ubiquitin and UBL pathways are associated with numerous diseases such as cancer, neurodegenerative disorders and viral infections. Brenda Schulman's Department “Molecular Machines and Signaling” has shown that hundreds of microscopic, dynamic, multiprotein molecular machines are transiently transformed into different conformations by specialized regulatory factors to control ubiquitin and UBLs in order to regulate virtually all aspects of cell biology.
A widespread mechanism regulating the functions of eukaryotic proteins involves post-translational modification by the small protein ubiquitin (UB) or structurally related ubiquitin-like proteins (UBLs).
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Department News
Great representation from our team at the "Understanding Ubiquitylation: From Molecular Mechanisms to Disease" symposium in Würzburg! Brenda was an invited speaker, Leo gave a selected short talk, and Jakob, Sam, and Sara presented posters. Hannah also attended this valuable scientific exchange.
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New Publication in Nature Structural & Molecular Biology -> Our TRIP12 structures reveal its active site at high resolution forming K29-linked and K29/K48-branched chains, showing key HECT E3 elements for the first time and suggesting a consensus mechanism for HECT E3s. Congratulations Sam, Laura, Ronnald, Joanna, Kirby and collaborators Matthew & Monique from Leiden University!
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Frank and Leo attended the annual Ubiquitin & Friends Symposium in Vienna. Leo received the best short talk prize with “ Deciphering the Ubiquitin Degradation Code”. Congrats Leo!
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The EU-funded prestigious Marie Skłodowska-Curie Actions Postdoctoral Fellowship supports outstanding researchers, innovative research and collaboration for 2 years period. Congratulations Zebin!
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