Brenda Schulman

Brenda Schulman

Research Department Molecular Machines and Signaling

Structural Biology, Ubiquitin Proteasome System, Ubiquitin-like Protein

An important form of regulation is the modification of proteins and membranes by linking them to the small protein ubiquitin or structurally related ubiquitin-like proteins (UBLs). Ubiquitin and UBLs control timing, subcellular location, composition, conformation and activity of thousands of different proteins and macromolecules. In addition, defects in ubiquitin and UBL pathways are associated with numerous diseases such as cancer, neurodegenerative disorders and viral infections. Brenda Schulman's Department “Molecular Machines and Signaling” has shown that hundreds of microscopic, dynamic, multiprotein molecular machines are transiently transformed into different conformations by specialized regulatory factors to control ubiquitin and UBLs in order to regulate virtually all aspects of cell biology.


Research Overview
A widespread mechanism regulating the functions of eukaryotic proteins involves post-translational modification by the small protein ubiquitin (UB) or structurally related ubiquitin-like proteins (UBLs). more

 

Department News

Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
20.02.2024
New Publication -
Congratulations to Joanna, Ishita and Rajan! more
Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases
07.02.2024
New Publication
- Congratulations to Joanna, Sam, David and Rajan!
-> Press Release: How cells sort their trash
Targeted Protein Degradation
21-24.01.2024
Brenda (organizer and speaker) and Laura (poster) participated the symposium in Colorado!

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