Brenda Schulman

Brenda Schulman

Research Department Molecular Machines and Signaling (MoMaS)

Structural Biology, Ubiquitin Proteasome System, Ubiquitin-like Protein

An important form of regulation is the modification of proteins and membranes by linking them to the small protein ubiquitin or structurally related ubiquitin-like proteins (UBLs). Ubiquitin and UBLs control timing, subcellular location, composition, conformation and activity of thousands of different proteins and macromolecules. In addition, defects in ubiquitin and UBL pathways are associated with numerous diseases such as cancer, neurodegenerative disorders and viral infections. Brenda Schulman's Department “Molecular Machines and Signaling” has shown that hundreds of microscopic, dynamic, multiprotein molecular machines are transiently transformed into different conformations by specialized regulatory factors to control ubiquitin and UBLs in order to regulate virtually all aspects of cell biology.

 

Research Overview
A widespread mechanism regulating the functions of eukaryotic proteins involves post-translational modification by the small protein ubiquitin (UB) or structurally related ubiquitin-like proteins (UBLs). more

 

Department News

Zebin is MSCA Postdoctoral Fellowship Awardee
The EU-funded prestigious Marie Skłodowska-Curie Actions Postdoctoral Fellowship supports outstanding researchers, innovative research and collaboration for 2 years period. Congratulations Zebin! more
4th Frankfurt Conference on Quality Control in Life Processes
Brenda presented our recent work on UbiREAD at this exciting conference. Alina and Frank shared their research through posters, while Celine, Ekam, and Juliane joined to learn about the latest advances in the field. more
UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
New Publication in Molecular Cell: A new technology to decipher the intricacies of the ubiquitin code within cells. Congratulations Leo! -> ­Press Release more
The Murray - Schulman Retreat took place in Ringberg Castle

The Murray - Schulman Retreat took place in Ringberg Castle

March 21, 2025
We held an amazing retreat with the Immunoregulation Research Group of Peter Murray in the Ringberg Castle. Our special thanks to the keynote speaker Prof. Hidde Ploegh and guest speakers Dr. Thierry Nordmann and Dr. Kamyar Hadian for their exciting presentations and stimulating discussions.

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