Brenda Schulman

Brenda Schulman

Research Department Molecular Machines and Signaling (MoMaS)

Structural Biology, Ubiquitin Proteasome System, Ubiquitin-like Protein

An important form of regulation is the modification of proteins and membranes by linking them to the small protein ubiquitin or structurally related ubiquitin-like proteins (UBLs). Ubiquitin and UBLs control timing, subcellular location, composition, conformation and activity of thousands of different proteins and macromolecules. In addition, defects in ubiquitin and UBL pathways are associated with numerous diseases such as cancer, neurodegenerative disorders and viral infections. Brenda Schulman's Department “Molecular Machines and Signaling” has shown that hundreds of microscopic, dynamic, multiprotein molecular machines are transiently transformed into different conformations by specialized regulatory factors to control ubiquitin and UBLs in order to regulate virtually all aspects of cell biology.

 

Research Overview
A widespread mechanism regulating the functions of eukaryotic proteins involves post-translational modification by the small protein ubiquitin (UB) or structurally related ubiquitin-like proteins (UBLs). more

 

Department News

Dawa is an Otto Hahn Medal Honoree
MoMaS Alumna Dawafuti Sherpa is awarded the prestigious Otto Hahn Medal of the Max Planck Society for establishing a new paradigm for substrate targeting by E3 ubiquitin ligases and ubiquitin dependent regulation of metabolism more
Ubiquitin and Ub-like Proteins

Ubiquitin and Ub-like Proteins

June 09, 2024
Brenda (speaker) and Karthik (poster) attended the FASEB Science Research Conference - Ubiquitin and Ub-like Proteins in Niagara Falls, New York.
Anna Bieber defended her PhD thesis

Anna Bieber defended her PhD thesis

June 05, 2024
Congratulations Anna!
Jakob attended the CPS 2024

Jakob attended the CPS 2024

June 02, 2024
Jakob was at the 9th Chemical Protein Synthesis Conference in Nagoya, Japan.

more...

Go to Editor View