Press Page Karl Duderstadt

Research in our group is focused on the molecular mechanisms that ensure accurate chromosome replication and organization. We develop novel single-molecule imaging approaches to characterize dynamic intermediates formed during these processes. Our long-term objective is to study the interplay between chromosome organization and replication to understand how barriers integral to chromosome architecture are overcome.

To support this effort, the group is organized into teams focused in different areas: development of novel imaging methods, characterization of complexes critical for chromosome organization, and DNA replication mechanism.


News

For efficient packaging, DNA is placed in loops. The cohesin ring (pink) forms the basis for the loop. The protein complex MCM (yellow) limits the loop formation.

Researchers at the MPI of Biochemistry have discovered that the protein complex MCM has an unexpected influence on the three-dimensional organization of DNA.
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<p style="text-align: left;" align="center">Three ERC Starting Grants for Group Leaders at the MPIB</p>

The European Research Council (ERC) encourages excellent research in Europe to promote visionary projects and open up new interdisciplinary science areas. Three young research group leaders at the Max… more

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