Brenda Schulman, head of the department „Molecular Machines and Signaling“ at the Max Planck Institute of Biochemistry in Martinsried receives the Advanced Grant of the European Research Council. It comes with a funding of 2.2 million Euros over five years. Together with her team, Schulman wants to find out the numerous ways the ubiquitin-like protein NEDD8 activates hundreds of distinct but related ubiquitin ligase machineries. The understanding of these protein machineries on structural, functional, and cellular levels will help to understand a large family of regulatory complexes that controla major part of eukaryotic biology, like immunity or cell division and thereby plays a central role in many diseases.
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