Department News

Noncanonical assembly, neddylation and chimeric cullin–RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex
11.04.2024
New Publication - Congratulations to Daniel, Linus, Ishi, Jiale, Sebastian, Raj, Luca and all the other authors. more
Visualizing chaperone-mediated multistep assembly of the human 20S proteasome
10.04.2024
New Publication -
Congratulations Frank, Jiale, Susanne and all the collaborators.
@ Aligning Science Across Parkinson’s (ASAP) Team Harper more
Linus Hopf defended his PhD thesis

Linus Hopf defended his PhD thesis

08.04.2024
Congratulations Linus!
Skraban-Deardorff intellectual disability syndrome-associated mutations in WDR26 impair CTLH E3 complex assembly
04.04.2024
New Publication -
Congratulations to Annette, Judith, Jakub, Karthik, Dawa and Arno. Great collaboration with Murray Group. more
Eleftheria Papadopoulou is awarded BIF PhD Fellowship

Eleftheria Papadopoulou is awarded BIF PhD Fellowship

19.03.2024
Congratulations Ria!
Combinatorial selective ER-phagy remodels the ER during neurogenesis
01.03.2024
New Publication & Journal Cover -
Congratulations to Cristina and Anna! And thanks to collaborators Melissa and Wade for visiting and making this happen
@ Aligning Science Across Parkinson’s (ASAP) Team Harper more
Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
20.02.2024
New Publication in Molecular Cell-
Congratulations to Joanna, Ishita, Rajan and collaborators! Amazing this started from Gary’s summer sabbatical!
Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases
07.02.2024
New Publication
- Congratulations to Joanna, Sam, David, Rajan and the summer member of the lab Gary!
-> Press Release: How cells sort their trash
Targeted Protein Degradation
21-24.01.2024
Brenda (organizer and speaker), Jakub (poster), and Laura (poster) participated the symposium in Colorado!
Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE
09.01.2024
New Publication in Nature Communications -
Congratulations Josie, Luca, Susanne and Bastian!
Postdoctoral fellowship from Peter und Traudl Engelhorn Stiftung to Jakob Farnung

Postdoctoral fellowship from Peter und Traudl Engelhorn Stiftung to Jakob Farnung

01.01.2024
Congratulations Jakob!
Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies
18.12.2023
New Publication in Molecular Cell
- Congratulations to Jakub, Dawa, Christine, Eleftheria, Laura, Viola, Susanne, Judith, Rajan and Arno!
Insights into the ISG15 transfer cascade by the UBE1L activating enzyme
02.12.2023
New Publication in Nature Communications -
Congratulations Khee, Rajan, Ronnald and Susanne!
Multiple awards at the IMPRS-ML Winter Seminar 2023

Multiple awards at the IMPRS-ML Winter Seminar 2023

30.11.2023
Josephine Botsch got the Best Poster First Place and Lukas Henneberg received the Best Talk Second Place. Congratulations Josie and Lukas!
BIF PhD Fellowship Awardee - Samuel Maiwald

BIF PhD Fellowship Awardee - Samuel Maiwald

29.11.2023
Congratulations Sam!
Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase
17.11.2023
New Publication -
Congratulations Ishi, Daniel, Khee, Arno and of course Nick! Fantastic this was inspired by one of Gary’s summer stints in the lab!
K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution
10.11.2023
New Publication in Molecular Cell -
Congratulations Daniel and the Beli lab!
Cristina is one of the October Open Science Champions of ASAP
31.10.2023
Congratulations to Cristina! She is one of the three October Open Science Champions of Aligning Science Across Parkinson’s (ASAP) She was one of the first to volunteer to participate in ASAP’s interview series, Protocol Particulars. Watch her interview here. more
Activity-based profiling of cullin–RING E3 networks by conformation-specific probes
31.08.2023
New Publication in
Nature Chemical Biology- Congratulations to Lukas and Khee! Special thanks to Matthias Mann and Sachdev Sidhu!
-> Press Release: New "radar" detects active cellular destroyers
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5
24.08.2023
New Publication in Nature Chemical Biology -
Congratulations Laura, Daniel, Rajan and Ronnald!
A Pro-Fluorescent Ubiquitin-Based Probe to Monitor Cysteine-Based E3 Ligase Activity
05.06.2023
New Publication in Angewandte Chemie Int. Ed.-
Congratulations David, Daniel, Josie, Laura and Sebastian! Special thanks to Monique for including us!
In memory of Professor Huib Ovaa, his passion for science will always be an inspiration to us.
Best Poster First Place: Josephine Botsch at EMBO Workshop

Best Poster First Place: Josephine Botsch at EMBO Workshop

25.05.2023
Josie’s poster was selected the Best Poster at the EMBO Workshop - Protein Quality Control: From molecular mechanisms to therapeutic intervention. Congratulations Josie!
Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum
24.05.2023
New Publication -
Congratulations Bastian! Thanks Ivan for including us!
Multiple awards for Schulman Department at Ubiquitin & Friends Symposium
28.04.2023
Best Short Talk Prize was given to Jakob Farnung and Leo Kiss received a Travel Award. Congratulations Jakob and Leo! more
Systemwide disassembly and assembly of SCF ubiquitin ligase complexes
06.04.2023
New Publication
- Congratulations to Khee, Dany and Lukas!
-> Press Release: Rock'n'roll mechanism helps to target proteins for degradation
Brenda receives ERC Advanced Grant for UPSmeetMet project

Brenda receives ERC Advanced Grant for UPSmeetMet project

30.03.2023
New Funding
- UPSmeetMEt will study the crosstalk between the ubiquitin system and metabolism! Congratulations Brenda!
-> Press Release
BIF PhD Fellowship Awardee - Alina Thielen

BIF PhD Fellowship Awardee - Alina Thielen

21.03.2023
Congratulations Alina!
In situ snapshots along a mammalian selective autophagy pathway
14.03.2023
New Publication -
Congrats Meijing, Ishi and Florian!
BIF PhD Fellowship Awardee - Luca Stier

BIF PhD Fellowship Awardee - Luca Stier

28.02.2023
Congratulations Luca!
E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity
16.02.2023
New Publication in Molecular Cell -
Congratulations Dany and Khee!
Brenda receives 2023 Louis-Jeantet Prize for Medicine
24.01.2023
Award
- Joint with Ivan Ðikić (Goethe Uni.), Brenda was awarded for her scientific contributions to our understanding of the function of ubiquitin and its mechanisms in cells. Congratulations Brenda!
-> Press Release
Ishita completed her PhD

Ishita completed her PhD

05.09.2023
Congratulations Ishi!
Leo is awarded EMBO long-term fellowship

Leo is awarded EMBO long-term fellowship

16.12.2022
EMBO Long-Term Fellowships are awarded for a period of two years to internationally mobile postdoctoral researchers in Europe and around the world. Congrats Leo!
Dawafuti defended her doctoral thesis

Dawafuti defended her doctoral thesis

09.12.2022
Congrats Dawa!
Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation
02.12.2022
New Publication in eLife -
Congratulations Dawa, Judith, Jakub, Karthik, Christine, Annette, Oliver and Arno!
COSB 2021 Best Paper Award to ‘NEDD8 and Ubiquitin Ligation by Cullin-RING E3 Ligases’
31.10.2022
Khee’s article is one of the winners of the inaugural 2021 Best Paper award of the journal Current Opinion in Structural Biology. Congratulations Khee! more
Kheewoong completed his PhD

Kheewoong completed his PhD

28.09.2022
Congrats Khee!
In situ structural analysis reveals membrane shape transitions during autophagosome formation
19.09.2022
New Publication in PNAS -
Congratulations Anna, Cristina and Florian!
Structure of CRL7FBXW8 reveals coupling with CUL1–RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation
18.08.2022
New Publication -
Congratulations Linus, Khee, Maren and Susanne!
MPIB Junior Scientists’ Publication Award to Jakub and Dawafuti

MPIB Junior Scientists’ Publication Award to Jakub and Dawafuti

22.07.2022
Congrats Dawa & Jakub!
Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation
01.06.2022
New Publication - Congratulations Shuai, Dawa, Jakub, Maximilian, Susanne and Florian!
Joanna completed her doctoral thesis

Joanna completed her doctoral thesis

03.05.2022
Congrats Asia!
Daniel got his Dr. title

Daniel got his Dr. title

03.05.2022
Congratulations Daniel!
A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters
19.04.2022
New Publication -
Congratulations Christine, Viola, Jakub and Dawa!
Sebastian defended his doctoral thesis

Sebastian defended his doctoral thesis

28.03.2022
Congrats Sebi!
New classes of E3 ligases illuminated by chemical probes
25.02.2022
New Review - Congratulations Daniel!
Jakub finished his PhD

Jakub finished his PhD

11.02.2022
Congrats Jakub!
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