Reinhard Fässler

Reinhard Fässler

Research Department "Molecular Medicine"

Integrin, Adhesion Signalling, Mouse Genetics

Integrins are receptors on the cell surface that bind proteins of the extracellular matrix and connect them to the actin-myosin cytoskeleton. By orchestrating the gradual assembly of a gigantic signaling hub with hundreds of proteins, integrins can trigger biochemical signals and transmit and receive mechanical signals. Reinhard Fässler's Department "Molecular Medicine" is investigating how integrins assemble and disassemble their large and complex signaling hubs.


Integrins are cell surface receptors that link proteins of the extracellular matrix with the actin cytoskeleton. The ligand binding property of integrins requires an activation step that is characterized by a conformational change of the ectodomain, separation of the transmembrane and cytoplasmic domains and the opening of the ligand binding pocket. more


Independent Research Groups

Gurumoorthy Krishnamoorty
Neuroinflammation and Mucosal Immunology more
Jürgen Cox
Computational Systems Biochemistry more
Go to Editor View