Research Department Molecular Medicine
Integrin, Adhesion Signalling, Mouse Genetics
Integrins are receptors on the cell surface that bind proteins of the extracellular matrix and connect them to the actin-myosin cytoskeleton. By orchestrating the gradual assembly of a gigantic signaling hub with hundreds of proteins, integrins can trigger biochemical signals and transmit and receive mechanical signals. Reinhard Fässler's Department "Molecular Medicine" is investigating how integrins assemble and disassemble their large and complex signaling hubs.