Publications

2021

Scherr Matthias, Wahab Syafiq Abd, Remus Dirk and Duderstadt Karl E. Born to Slide: Mobile Origin Licensing Factors Confer Resistance to Transcription Conflicts. Available at SSRN: https://ssrn.com/abstract=3775178

Bauernfried S, Scherr MJ, Pichlmair A, Duderstadt KE, Hornung V. Human NLRP1 is a sensor for double-stranded RNA. Science. Vol. 371, Issue 6528, Jan 29 (2021). 

2020

Marta Urbanska, Annemarie Lüdecke, Wim J. Walter, Antoine M. van Oijen, Karl E. Duderstadt, Stefan Diez. Highly-parallel microfluidics-based force spectroscopy on single cytoskeletal motors bioRxiv 2020.08.11.245910; doi: https://doi.org/10.1101/2020.08.11.245910

Bart J. H. Dequeker, Hugo B. Brandão, Matthias J. Scherr, Johanna Gassler, Sean Powell, Imre Gaspar, Ilya M. Flyamer, Wen Tang, Roman Stocsits, Iain F. Davidson, Jan-Michael Peters, Karl E. Duderstadt, Leonid A. Mirny, Kikuё Tachibana. MCM complexes are barriers that restrict cohesin-mediated loop extrusion bioRxiv 2020.10.15.340356; doi: https://doi.org/10.1101/2020.10.15.340356

Agarwal, R., Duderstadt, K.E. Multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision. Nat Commun 11, 4714 (2020).

2018

van Oijen, A.M., Duderstadt, K.E., Xiao, J., and Fishel, R. Plasticity of Multi-Protein Complexes. Journal of Molecular Biology 430, 4441 (2018).

Hill, F.R., van Oijen, A.M., and Duderstadt, K.E. Detection of kinetic change points in piece-wise linear single molecule motion. The Journal of Chemical Physics 148, 123317 (2018).

Duderstadt, K.E. How to Follow a Traveler with a Brownian Swagger. Biophysical Journal 115, 165 (2018). 

Scherr, M.J., Safaric, B., and Duderstadt, K.E. Noise in the Machine: Alternative Pathway Sampling is the Rule During DNA Replication. Bioessays 77, 1700159 (2018).

2017

Lewis, J.S., Spenkelink, L.M., Jergic, S., Wood, E.A., Monachino, E., Horan, N.P., Duderstadt, K.E., Cox, M.M., Robinson, A., Dixon, N.E., and van Oijen, A. M. Single-molecule visualization of fast polymerase turnover in the bacterial replisome. Elife 6, 4846 (2017).

2016

Duderstadt, K.E., Geertsema, H.J., Stratmann, S.A., Punter, C.M., Kulczyk, A.W., Richardson, C.C., and van Oijen, A.M. Simultaneous Real-Time Imaging of Leading and Lagging Strand Synthesis Reveals the Coordination Dynamics of Single Replisomes. Molecular Cell 64, 1035-1047 (2016).

Åberg, C., Duderstadt, K.E., and van Oijen, A.M. Stability versus exchange: a paradox in DNA replication. Nucleic Acids Research 44, 4846–4854 (2016). 

2015

Geertsma, H.J., Duderstadt, K.E., and van Oijen, A.M. Single-­molecule observation of prokaryotic DNA replication. Methods in Enzymology 1300, 219-238 (2015).  

2013

Duderstadt, K.E., ReyesLamothe, R., van Oijen, A.M., and Sherratt, D.J. ReplicationFork Dynamics. Cold Spring Harbor Perspectives in Biology (2013). 

Duderstadt, K.E., and Berger, J.M. A structural framework for replication origin opening by AAA+ initiation factors. Curr. Opin. Struc. Biol. 23, 144–153 (2013). 

2011

Duderstadt, K.E., Chuang, K., and Berger, J.M. DNA stretching by bacterial initiators promotes replication origin opening. Nature 478, 209-­213 (2011). 

2010

Duderstadt, K.E., Mott, M.L., Crisona, N.J., Chuang, K., Yang, H., and Berger, J.M. Origin remodeling and opening in bacteria rely on distinct assembly states of the DnaA initiator. J. Biol. Chem. 285, 28229-­28239 (2010).  

Dedeo, M.T., Duderstadt, K.E., Berger, J.M., and Francis, M. B. Nanoscale protein assemblies from a circular permutant of the tobacco mosaic virus. Nano Lett. 10, 181-­186 (2010). 

2008

Duderstadt, K.E., and Berger, J.M. AAA+ ATPases in the initiation of DNA replication. Crit. Rev. Biochem. Mol. Biol. 43, 163187 (2008). 

van Petegem, F., Duderstadt, K.E., Clark, K.A., Wang M., and Minor, D.L., Jr. Alaninescanning mutagenesis defines a conserved energetic hotspot in the CaValpha1 AIDCaVbeta interaction site that is critical for channel modulation. Structure 16, 280294 (2008). 

2007

Hanson, J.A., Duderstadt, K.E., Watkins, L. P., Bhattacharyya, S., Brokaw, J., Chu, J.W., and Yang, H. Illuminating the mechanistic roles of enzyme conformational dynamics. Proc. Natl. Acad. Sci. U. S. A. 104, 18055-­18060 (2007). 

2006

Michelsen, K., Mrowiec, T., Duderstadt, K.E., Frey, S., Minor, D.L., Jr., Mayer, M.P., and Schwappach B. A multimeric membrane protein reveals 14-­3-­3 isoform specificity in forward transport in yeast. Traffic 7, 903-­916 (2006). 

 

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