Publications

2020


1.
Achim Keidel, Elena Conti, Sebastian Falk.
Purification and Reconstitution of the S. cerevisiae TRAMP and Ski Complexes for Biochemical and Structural Studies.
Methods Mol Biol. 2020;2062:491-513.

2019


2.
Yair Gat, Jan Michael Schuller, Mahesh Lingaraju, Elisabeth Weyher, Fabien Bonneau, Mike Strauss, Peter J. Murray, and Elena Conti, "InsP(6) binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complex," NATURE STRUCTURAL & MOLECULAR BIOLOGY 26 (12), 1089-1093 (2019).
3.
Mahesh Lingaraju, Dennis Johnsen, Andreas Schlundt, Lukas M. Langer, Jerome Basquin, Michael Sattler, Torben Heick Jensen, Sebastian Falk, and Elena Conti, "The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs," NATURE COMMUNICATIONS 10, 3393 (2019).
4.
Ingmar B. Schäfer, Masami Yamashita, Jan Michael Schuller, Steffen Schüssler, Peter Reichelt, Mike Strauss, and Elena Conti, "Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase," Cell 177 (6), 1619-1631.e21 (2019).

2018


5.
Piotr Gerlach, Jan M. Schuller, Fabien Bonneau, Jerome Basquin, Peter Reichelt, Sebastian Falk, and Elena Conti, "Distinct and evolutionary conserved structural features of the human nuclear exosome complex," eLife 7, e38686 (2018).
6.
Jan Michael Schuller, Sebastian Falk, Lisa Fromm, Ed Hurt, and Elena Conti, "Structure of the nuclear exosome captured on a maturing preribosome," Science 360 (6385), 219-222 (2018).

2017


7.
Lisa Fromm, Sebastian Falk, Dirk Flemming, Jan Michael Schuller, Matthias Thoms, Elena Conti, and Ed Hurt, "Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome," Nature Communications 8, 1787 (2017).
8.
Sebastian Falk, Jan-Niklas Tants, Jerome Basquin, Matthias Thoms, Ed Hurt, Michael Sattler, and Elena Conti, "Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53," RNA 23 (12), 1780-1787 (2017).
9.
Sebastian Falk, Fabien Bonneau, Judith Ebert, Alexander Kögel, and Elena Conti, "Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase," Cell Reports 20 (10), 2279-2286 (2017).
10.
Bronislava Leonaite, Zhong Han, Jerome Basquin, Fabien Bonneau, Domenico Libri, Odil Porrua, and Elena Conti, "Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family," EMBO Journal 36 (11), 1590-1604 (2017).
11.
Liang Li, Mahesh Lingaraju, Claire Basquin, Jerome Basquin, and Elena Conti, "Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins," RNA 23 (7), 1028-1034 (2017).

2016


12.
Christian Schmidt, Eva Kowalinski, Vivekanandan Shanmuganathan, Quentin Defenouillere, Katharina Braunger, Andre Heuer, Markus Pech, Abdelkader Namane, Otto Berninghausen, Micheline Fromont-Racine, Alain Jacquier, Elena Conti, Thomas Becker, and Roland Beckmann, "The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex," Science 354 (6318), 1431-1433 (2016).
13.
Sebastian Falk, Ksenia Finogenova, Mireille Melko, Christian Benda, Soren Lykke-Andersen, Torben Heick Jensen, and Elena Conti, "Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors," Nature Communications 7, 13573 (2016).
14.
Eva Kowalinski, Alexander Kögel, Judith Ebert, Peter Reichelt, Elisabeth Stegmann, Bianca Habermann, and Elena Conti, "Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex," Molecular Cell 63 (1), 125-134 (2016).
15.
Katharina Nakel, Fabien Bonneau, Claire Basquin, Bianca Habermann, Christian R. Eckmann, and Elena Conti, "Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity," RNA 22 (8), 1139-1145 (2016).
16.
Lela Vukovic, Christophe Chipot, Debora L. Makino, Elena Conti, and Klaus Schulten, "Molecular Mechanism of Processive 3 ' to 5 ' RNA Translocation in the Active Subunit of the RNA Exosome Complex," JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 138 (12), 4069-4078 (2016).

2015


17.
J. Rajan Prabu, Marisa Müller, Andreas W. Thomae, Steffen Schüssler, Fabien Bonneau, Peter B. Becker, and Elena Conti, "Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling," MOLECULAR CELL 60 (3), 487-499 (2015).
18.
Sevim Ozgur, Jerome Basquin, Anastasiia Kamenska, Witold Filipowicz, Nancy Standart, and Elena Conti, "Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex," CELL REPORTS 13 (4), 703-711 (2015).
19.
Debora Lika Makino, Benjamin Schuch, Elisabeth Stegmann, Marc Baumgärtner, Claire Basquin, and Elena Conti, "RNA degradation paths in a 12-subunit nuclear exosome complex," NATURE 524 (7563), 54-58 (2015).
20.
Katharina Nakel, Fabien Bonneau, Christian R. Eckmann, and Elena Conti, "Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3," PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112 (28), 8614-8619 (2015).
21.
Kundan Sharma, Ajla Hrle, Katharina Kramer, Timo Sachsenberg, Raymond H.J. Staals, Lennart Randau, Anita Marchfelder, John van der Oost, Oliver Kohlbacher, Elena Conti, and Henning Urlaub, "Analysis of protein–RNA interactions in CRISPR proteins and effector complexes by UV-induced cross-linking and mass spectrometry.," Methods: A Companion to Methods in Enzymology. 89 (Special Issue: Mass Spectrometry-Based Structural Biology), 138-148 (2015).
22.
Eva Kowalinski, Anthony Schuller, Rachel Green, and Elena Conti, "Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases," STRUCTURE 23 (7), 1336-1343 (2015).
23.
Varun Bhaskar, Jerome Basquin, and Elena Conti, "Architecture of the Ubiquitylation Module of the Yeast Ccr4-Not Complex," STRUCTURE 23 (5), 921-928 (2015).
24.
Sevim Ozgur, Gretel Buchwald, Sebastian Falk, Sutapa Chakrabarti, Jesuraj Rajan Prabu, and Elena Conti, "The conformational plasticity of eukaryotic RNA-dependent ATPases.," The FEBS Journal 282 (5), 850-863 (2015).

2014


25.
Benjamin Schuch, Monika Feigenbutz, Debora L. Makino, Sebastian Falk, Claire Basquin, Phil Mitchell, and Elena Conti, "The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase.," The EMBO journal 33 (23), 2829-2846 (2014).
26.
Christian Benda, Judith Ebert, Richard A. Scheltema, Herbert B. Schiller, Marc Baumgärtner, Fabien Bonneau, Matthias Mann, and Elena Conti, "Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4," MOLECULAR CELL 56 (1), 43-54 (2014).
27.
Sebastian Falk, John R. Weir, Jendrik Hentschel, Peter Reichelt, Fabien Bonneau, and Elena Conti, "The Molecular Architecture of the TRAMP Complex Reveals the Organization and Interplay of Its Two Catalytic Activities," MOLECULAR CELL 55 (6), 856-867 (2014).
28.
Ajla Hrle, L. K. Maier, K. Sharma, Judith Ebert, Claire Basquin, H. Urlaub, A. Marchfelder, and Elena Conti, "Structural analyses of the CRISPR protein Csc2 reveal the RNA-binding interface of the type I-D Cas7 family.," RNA Biology 11 (8), 1072-1082 (2014).
29.
Michiel van de Waterbeemd, Philip Lössl, Violette Gautier, Fabio Marino, Masami Yamashita, Elena Conti, Arjen Scholten, and Albert J. R. Heck, "Simultaneous Assessment of Kinetic, Site-Specific, and Structural Aspects of Enzymatic Protein Phosphorylation," ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53 (36), 9660-9664 (2014).
30.
Sutapa Chakrabarti, Fabien Bonneau, Steffen Schüssler, Elfriede Eppinger, and Elena Conti, "Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6," NUCLEIC ACIDS RESEARCH 42 (14), 9447-9460 (2014).
31.
Ingmar B. Schäfer, Michaela Rode, Fabien Bonneau, Steffen Schüssler, and Elena Conti, "The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase," NATURE STRUCTURAL & MOLECULAR BIOLOGY 21 (7), 591-598 (2014).
32.
Hansruedi Mathys, Jerome Basquin, Sevim Ozgur, Mariusz Czarnocki-Cieciura, Fabien Bonneau, Aafke Aartse, Andrzej Dziembowski, Marcin Nowotny, Elena Conti, and Witold Filipowicz, "Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression," MOLECULAR CELL 54 (5), 751-765 (2014).
33.
André Plagens, Vanessa Tripp, Michael Daume, Kundan Sharma, Andreas Klingl, Ajla Hrle, Elena Conti, Henning Urlaub, and Lennart Randau, "In vitro assembly and activity of an archaeal CRISPR-Cas type I-A Cascade interference complex.," Nucleic Acids Research (London) 42 (8), 5125-5138 (2014).

2013


34.
Gretel Buchwald, Steffen Schüssler, Claire Basquin, Herve Le Hir, and Elena Conti, "Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain," Proceedings of the National Academy of Sciences of the United States of America 110 (48), E4611-E4618 (2013).
35.
Debora Lika Makino and Elena Conti, "Structure determination of an 11-subunit exosome in complex with RNA by molecular replacement," ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 69, 2226-2235 (2013).
36.
Humayun Sharif and Elena Conti, "Architecture of the Lsm1-7-Pat1 Complex: A Conserved Assembly in Eukaryotic mRNA Turnover," CELL REPORTS 5 (2), 283-291 (2013).
37.
V. Bhaskar, V. Roudko, J. Basquin, K. Sharma, H. Urlaub, B. Seraphin, and E. Conti, "Structure and RNA-binding properties of the Not1-Not2Not5 module of the yeast Ccr4-Not complex.," Nature Structrural and Molecular Biology 12 (20), 1281-1288 (2013).
38.
Ajla Hrle, Andreas A. H. Su, Judith Ebert, Christian Benda, Lennart Randau, and Elena Conti, "Structure and RNA-binding properties of the Type III-A CRISPR-associated protein Csm3," RNA BIOLOGY 10 (11), 1670-1678 (2013).
39.
Debora L. Makino, Felix Halbach, and Elena Conti, "The RNA exosome and proteasome: common principles of degradation control," NATURE REVIEWS MOLECULAR CELL BIOLOGY 14 (10), 654-660 (2013).
40.
Felix Halbach, Peter Reichelt, Michaela Rode, and Elena Conti, "The Yeast Ski Complex: Crystal Structure and RNA Channeling to the Exosome Complex," CELL 154 (4), 814-826 (2013).
41.
Humayun Sharif, Sevim Ozgur, Kundan Sharma, Claire Basquin, Henning Urlaub, and Elena Conti, "Structural analysis of the yeast Dhh1-Pat1 complex reveals how Dhh1 engages Pat1, Edc3 and RNA in mutually exclusive interactions," NUCLEIC ACIDS RESEARCH 41 (17), 8377-8390 (2013).
42.
Holger von Moeller, Rachel Lerner, Adele Ricciardi, Claire Basquin, William F. Marzluff, and Elena Conti, "Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins," NUCLEIC ACIDS RESEARCH 41 (16), 7960-7971 (2013).
43.
Debora L. Makino, Marc Baumgärtner, and Elena Conti, "Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex," NATURE 495 (7439), 70-75 (2013).
44.
Thomas Holder, Claire Basquin, Judith Ebert, Nadine Randel, Didier Jollivet, Elena Conti, Gaspar Jekely, and Fulvia Bono, "Deep transcriptome-sequencing and proteome analysis of the hydrothermal vent annelid Alvinella pompejana identifies the CvP-bias as a robust measure of eukaryotic thermostability," BIOLOGY DIRECT 8, 2 (2013).

2012


45.
Esben Lorentzen and Elena Conti, "Crystal Structure of a 9-Subunit Archaeal Exosome in Pre-Catalytic States of the Phosphorolytic Reaction," ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL , 721869 (2012).
46.
Jerome Basquin, Vladimir V. Roudko, Michaela Rode, Claire Basquin, Bertrand Seraphin, and Elena Conti, "Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction," Molecular Cell 48 (2), 207-218 (2012).
47.
R. Melero, G. Buchwald, R. Castano, M. Raabe, D. Gil, M. Lazaro, H. Urlaub, E. Conti, and O. Llorca, "The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3 ' end," Nature Structural & Molecular Biology 19 (5), 498-595 (2012).
48.
A. A. Jeyaprakash, A. Santamaria, U. Jayachandran, Y. W. Chan, C. Benda, E. A. Nigg, and E. Conti, "Structural and Functional Organization of the Ska Complex, a Key Component of the Kinetochore-Microtubule Interface," Molecular Cell 46 (3), 274-286 (2012).
49.
A. G. Murachelli, J. Ebert, C. Basquin, H. Le Hir, and E. Conti, "The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex," Nature Structural & Molecular Biology 19 (4), 378-386 (2012).
50.
F. Halbach, M. Rode, and E. Conti, "The crystal structure of S. cerevisiae Ski2, a DExH helicase associated with the cytoplasmic functions of the exosome," RNA-A Publication of the RNA Society 18 [2012] (1), 124-134 (2011).

2011


51.
A. A. Jeyaprakash, C. Basquin, U. Jayachandran, and E. Conti, "Structural Basis for the Recognition of Phosphorylated Histone H3 by the Survivin Subunit of the Chromosomal Passenger Complex," Structure 19 (11), 1625-1634 (2011).
52.
S. Chakrabarti, U. Jayachandran, F. Bonneau, F. Fiorini, C. Basquin, S. Domcke, H. Le Hir, and E. Conti, "Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and Its Regulation by Upf2," Molecular Cell 41 (6), 693-703 (2011).

2010


53.
H. Malet, M. Topf, D. K. Clare, J. Ebert, F. Bonneau, J. Basquin, K. Drazkowska, R. Tomecki, A. Dziembowski, E. Conti, H. R. Saibil, and E. Lorentzen, "RNA channelling by the eukaryotic exosome," EMBO Reports 11 (12), 936-942 (2010).
54.
I. Kashima, S. Jonas, U. Jayachandran, G. Buchwald, E. Conti, A. N. Lupas, and E. Izaurralde, "SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay," Genes & Development 24 (21), 2440-2450 (2010).
55.
K. Nakel, S. A. Hartung, F. Bonneau, C. R. Eckmann, and E. Conti, "Four KH domains of the C. elegans Bicaudal-C ortholog GLD-3 form a globular structural platform," RNA-A Publication of the RNA Society 16 (11), 2058-2067 (2010).
56.
J. R. Weir, F. Bonneau, J. Hentschel, and E. Conti, "Structural analysis reveals the characteristic features of Mtr4, a DExH helicase involved in nuclear RNA processing and surveillance," Proceedings of the National Academy of Sciences of the United States of America 107 (27), 12139-12144 (2010).
57.
G. Buchwald, J. Ebert, C. Basquin, J. Sauliere, U. Jayachandran, F. Bono, H. Le Hir, and E. Conti, "Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.," Proceedings of the National Academy of Sciences of the United States of America 107 (22), 10050-10055 (2010).
58.
A. G. Cook and E. Conti, "Nuclear export complexes in the frame," Current Opinion in Structural Biology 20 (2), 247-252 (2010).
59.
F. Bono, A. G. Cook, M. Grünwald, J. Ebert, and E. Conti, "Nuclear Import Mechanism of the EJC Component Mago-Y14 Revealed by Structural Studies of Importin 13," Molecular Cell 37 (2), 211-222 (2010).

2009


60.
F. Bonneau, J. Basquin, J. Ebert, E. Lorentzen, and E. Conti, "The Yeast Exosome Functions as a Macromolecular Cage to Channel RNA Substrates for Degradation," Cell 139 (3), 547-559 (2009).
61.
A. G. Cook, N. Fukuhara, M. Jinek, and E. Conti, "Structures of the tRNA export factor in the nuclear and cytosolic states," Nature 461 (7260), 60-65 (2009).
62.
T. N. Gaitanos, A. Santamaria, A. A. Jeyaprakash, B. Wang, E. Conti, and E. A. Nigg, "Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3," EMBO Journal 28 (10), 1442-1452 (2009).
63.
H. von Moeller, C. Basquin, and E. Conti, "The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner," Nature Structural & Molecular Biology 16 (3), 247-254 (2009).

2008


64.
E. Lorentzen and E. Conti, "Expression, reconstitution, and structure of an archaeal RNA degrading exosome", in RNA Turnover in Prokaryotes, Archaea and Organelles, (Elsevier Academic Press Inc., San Diego, 2008), pp. 417-435.
65.
E. Lorentzen, J. Basquin, and E. Conti, "Structural organization of the RNA-degrading exosome," Current Opinion in Structural Biology 18 (6), 709-713 (2008).
66.
M. Jinek, A. Eulalio, A. Lingel, S. Helms, E. Conti, and E. Izaurralde, "The C-terminal region of Ge-1 presents conserved structural features required for P-body localization," RNA-A Publication of the RNA Society 14 (10), 1991-1998 (2008).
67.
E. Lorentzen, J. Basquin, R. Tomecki, A. Dziembowski, and E. Conti, "Structure of the active subunit of the yeast exosome core, Rrp44: Diverse modes of substrate recruitment in the RNase II nuclease family," MOLECULAR CELL 29 (6), 717-728 (2008).

2007


Structure of a Survivin-Borealin-INCENP Core Complex Reveals How Chromosomal Passengers Travel Together.
Jeyaprakash AA, Klein UR, Lindner D, Ebert J, Nigg EA, Conti E.
Cell. 2007 Oct 19;131(2):271-85.
Link Pubmed

Structural biology of nucleocytoplasmic transport.
Cook A, Bono F, Jinek M, Conti E.
Annu Rev Biochem. 2007;76:647-71.
Link Pubmed

RNA channelling by the archaeal exosome.
Lorentzen E, Dziembowski A, Lindner D, Seraphin B, Conti E.
EMBO Rep. 2007 May;8(5):470-6.
Link Pubmed

A single subunit, Dis3, is essentially responsible for yeast exosome core activity.
Dziembowski A, Lorentzen E, Conti E, Seraphin B.
Nat Struct Mol Biol. 2007 Jan;14(1):15-22.
Link Pubmed

Structural and biochemical characterization of the yeast exosome component Rrp40.
Oddone A, Lorentzen E, Basquin J, Gasch A, Rybin V, Conti E, Sattler M.
EMBO Rep. 2007 Jan;8(1):63-9.
Link Pubmed

2006


Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex.
Glavan F, Behm-Ansmant I, Izaurralde E, Conti E.
EMBO J. 2006 Nov 1;25(21):5117-25.
Link Pubmed

Structural insights into the Notch-modifying glycosyltransferase Fringe.
Jinek M, Chen YW, Clausen H, Cohen SM, Conti E.
Nat Struct Mol Biol. 2006 Oct;13(10):945-6.
Link Pubmed

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA.
Bono F, Ebert J, Lorentzen E, Conti E.
Cell. 2006 Aug 25;126(4):713-25.
Link Pubmed

Eukaryotic expression, purification, crystallization and preliminary X-ray analysis of murine Manic Fringe.
Jinek M, Conti E.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt 8):774-7.
Link Pubmed

The exosome and the proteasome: nano-compartments for degradation.
Lorentzen E, Conti E.
Cell. 2006 May 19;125(4):651-4. Review.
Link Pubmed

Chemical shift backbone assignments of TAP-N, the 31 kDa cargo-binding region of the protein TAP.
Pimienta G, Gabel F, Zanier K, Conti E, Sattler M.
J Biomol NMR. 2006;36 Suppl 1:23.
Link Pubmed

Karyopherin flexibility in nucleocytoplasmic transport.
Conti E, Muller CW, Stewart M.
Curr Opin Struct Biol. 2006 Apr;16(2):237-44. Review.
Link Pubmed

2005


Structural basis of 3' end RNA recognition and exoribonucleolytic cleavage by an exosome RNase PH core.
Lorentzen E, Conti E.
Mol Cell. 2005 Nov 11;20(3):473-81.
Link Pubmed

The archaeal exosome core is a hexameric ring structure with three catalytic subunits.
Lorentzen E, Walter P, Fribourg S, Evguenieva-Hackenberg E, Klug G, Conti E.
Nat Struct Mol Biol. 2005 Jul;12(7):575-81.
Link Pubmed

Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species.
Conti E, Izaurralde E.
Curr Opin Cell Biol. 2005 Jun;17(3):316-25. Review.
Link Pubmed

The structure of the nuclear export receptor Cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding.
Cook A, Fernandez E, Lindner D, Ebert J, Schlenstedt G, Conti E.
Mol Cell. 2005 Apr 29;18(3):355-67.
Link Pubmed

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.
Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E.
Mol Cell. 2005 Feb 18;17(4):537-47.
Link Pubmed

2004


The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha.
Jinek M, Rehwinkel J, Lazarus BD, Izaurralde E, Hanover JA, Conti E.
Nat Struct Mol Biol. 2004 Oct;11(10):1001-7.
Link Pubmed

Determinants for Aurora-A activation and Aurora-B discrimination by TPX2.
Bayliss R, Sardon T, Ebert J, Lindner D, Vernos I, Conti E.
Cell Cycle. 2004 Apr;3(4):404-7.
Link Pubmed

Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex.
Bono F, Ebert J, Unterholzner L, Guttler T, Izaurralde E, Conti E.
EMBO Rep. 2004 Mar;5(3):304-10.
Link Pubmed

Conformational variability of nucleo-cytoplasmic transport factors.
Fukuhara N, Fernandez E, Ebert J, Conti E, Svergun D.
J Biol Chem. 2004 Jan 16;279(3):2176-81.
Link Pubmed

2003


Structural basis of Aurora-A activation by TPX2 at the mitotic spindle.
Bayliss R, Sardon T, Vernos I, Conti E.
Mol Cell. 2003 Oct;12(4):851-62.
Link Pubmed

Structural similarity in the absence of sequence homology of the messenger RNA export factors Mtr2 and p15.
Fribourg S, Conti E.
EMBO Rep. 2003 Jul;4(7):699-703.
Link Pubmed

A novel mode of RBD-protein recognition in the Y14-Mago complex.
Fribourg S, Gatfield D, Izaurralde E, Conti E.
Nat Struct Biol. 2003 Jun;10(6):433-9.
Link Pubmed

2002


Structures of importins.
Conti E.
Results Probl Cell Differ. 2002;35:93-113. Review.
Link Pubmed

2001


Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor.
Fribourg S, Braun IC, Izaurralde E, Conti E.
Mol Cell. 2001 Sep;8(3):645-56.
Link Pubmed

Nucleocytoplasmic transport enters the atomic age.
Conti E, Izaurralde E.
Curr Opin Cell Biol. 2001 Jun;13(3):310-9. Review.
Link Pubmed

Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export.
Braun IC, Herold A, Rode M, Conti E, Izaurralde E.
J Biol Chem. 2001 Jun 8;276(23):20536-43.
Link Pubmed

2000


The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain.
Liker E, Fernandez E, Izaurralde E, Conti E.
EMBO J. 2000 Nov 1;19(21):5587-98.
Link Pubmed

Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha.
Conti E, Kuriyan J.
Structure. 2000 Mar 15;8(3):329-38.
Link Pubmed

1998


Structural basis for the inhibition of firefly luciferase by a general anesthetic.
Franks NP, Jenkins A, Conti E, Lieb WR, Brick P.
Biophys J. 1998 Nov;75(5):2205-11.
Link Pubmed

Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha.
Conti E, Uy M, Leighton L, Blobel G, Kuriyan J.
Cell. 1998 Jul 24;94(2):193-204.
Link Pubmed

X-ray and spectrophotometric studies of the binding of proflavin to the S1 specificity pocket of human alpha-thrombin.
Conti E, Rivetti C, Wonacott A, Brick P.
FEBS Lett. 1998 Mar 27;425(2):229-33.
Link Pubmed

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