Extended Publications


  1. Kobayashi, W.*, Sappler, A. H., Bollschweiler, D., Kümmecke, M., Basquin, J., Arslantas, E. N., Hornberger, R., Duderstadt, K.  & Tachibana, K. (2024).  Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition. Nature Structural & Molecular Biology


  2. Gassler, J.*, Kobayashi, W.*, Gáspár, I.*, Ruangroengkulrith, S.*, Mohanan, A., Gómez Hernández, L.,  Kravchenko, P., Kümmecke, M., Lalic, A., Rifel, N., Ashburn, R., Zaczek, M., Vallot, A., Cuenca Rico, L.,  Ladstätter, S., Tachibana, K. (2022). Zygotic genome activation by the totipotency pioneer factor Nr5a2.  Science 378(6626), 1305-1315.


  3. Dequeker, B.J.H.*, Scherr M.J.*, Brandão, HB., Gassler, J., Powell, S., Gaspar, I., Flyamer, I.M., Lalic A., Tang, W., Stocsits, R., Davidson, I.F., Peters, J.M., Duderstadt, K.E., Mirny, L.A., Tachibana, K. (2022). MCM complexes are barriers that restrict cohesin-mediated loop extrusion. Nature 606(7912):197-203.

    • Spotlight: https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00611-6 


  4. Nagano M., Hu B., Yokobayashi S., Yamamura A., Umemura F., Coradin M., Ohta H., Yabuta Y., Ishikura Y., Okamoto I., Ikeda H., Kawahira N., Nosaka Y., Shimizu S., Kojima Y., Mizuta K., Kasahara T., Imoto Y., Meehan K., Stocsits R., Wutz G., Hiraoka Y., Murakawa Y., Yamamoto T., Tachibana K., Peters J.M., Mirny L.A., Garcia B.A., Majewski J., Saitou M. (2022). Nucleome programming is required for the foundation of totipotency in mammalian germline development. EMBO J. 41(13):e110600


  5. Kaiser, F.M.P., Gruenbacher, S., Oyaga,.R., Nio, E., Jaritz, M., Sun, Q., van der Zwaag, W., Kreidl, E., Zopf, L.M., Dalm, V.A.S.H., Pel, J., Gaiser, C., van der Vliet, R., Wahl, L., Rietman, A., Hill, L., Leca, I., Driessen, G., Laffeber, C., Brooks, A., Katsikis, P.D., Lebbink, J.H.G., Tachibana, K., van der Burg, M., De Zeeuw, C.I., Badura, A., Busslinger, M. (2022) Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder. J Exp Med. 219(9):e20220498


  6. Chatzidaki, E.E., Powell, S., Dequeker ,B.J.H., Gassler, J., Silva, M.C.C., Tachibana, K. (2021). Ovulation suppression protects against chromosomal abnormalities in mouse eggs at advanced maternal age. Curr.Biol. 31(18):4038-4051.e7

    • Dispatch: Baumann, K., (2021) Nat. Rev. Mol. Cell Biol. 22, 586


  7. Silva, M.S., Ladstätter, S., Powell, S., Gassler, J., Tedeschi, A., Peters, J.M., Tachibana, K. (2020). Wapl releases Scc1-cohesin and regulates chromosome structure and segregation in mouse oocytes. J. Cell Biol. 219, e201906100.
  8. Du, Z., Zheng, H. Kawamura, Y.K., Zhang, K. Gassler, J., Powell, S., Xu, Q., Lin, Z., Xu, K., Zhou, Q., Ozonov, E.A., Veron, N., Huang, B., Li, L., Yu, G., Liu, L., Yeung, W.K.A., Wang, P., Chang, L., Wang, Q., He, A., Sun, Y., Na, J. Sun, Q., Sasaki, H., Tachibana, K., Peters, A.H.F.M., Xie, W. (2020). Polycomb Group proteins regulate chromatin architecture in mouse oocytes and early embryos. Mol. Cell. 77, 825-839.
  9. Vallot, A., and Tachibana, K. (2020). The emergence of genome architecture and zygotic genome activation. Curr. Opin.Cell Biol. 64, 50-57.
  10. Ladstätter, S., and Tachibana, K. (2019). Genomic insights into chromatin reprogramming to totipotency in embryos. J. Cell Biol. 218, 70-82.
  11. Tachibana, K. (2018). The beginning of totipotency. Nat. Rev. Mol. Cell Biol. 19, 417–417.
  12. Gassler, J., Flyamer, I.M., Tachibana, K. (2018). Single-nucleus Hi-C of mammalian oocytes and zygotes. Methods Cell Biol., pp. 389–407.
  13. Silva, M.C.C.*, Wutz, G.*, Tachibana, K., Peters, J.M. (2018). Analysis of chromosomes from mouse oocytes and mammalian cultured cells by light microscopy. Methods Cell Biol., pp. 287–305.
  14. Cuartero, S., Weiss, F.D., Dharmalingam, G., Guo, Y. Ing-Simmons, E., Masella, S., Robles-Rebollo, I., Xiao, X., Wang, Y.F., Barozzi, I., Djeghloul, D., Armano, M.T., Niskanen, H., Petretto, E., Dowell, R.D., Tachibana, K.,Kaikkonen, M.U., Nasmyth, K., Lenhard, B., Natoli, G., Fisher, A.G., Merkenschlager, M. (2018). Control of inducible gene expression links cohesin to hemotopoietic progenitor self-renewal and differentiation. Nat. Immunol. 19, 932-941.
  15. Szydłowska, A., Ladstätter, S., Tachibana, K. (2018). Manipulating Cohesin Levels in Live Mouse Oocytes. Methods Mol. Biol., pp. 113–128
  16. Gassler, J.*, Brandão, H.B.*, Imakaev, M., Flyamer, I.M., Ladstätter, S., Bickmore, W.A., Peters, J., Mirny, L.A., Tachibana, K. (2017). A mechanism of cohesin‐dependent loop extrusion organizes zygotic genome architecture. EMBO J. 36, 3600–3618.
    • News & Views: Haarhuis, J.H.I., and Rowland, B.D. (2017). EMBO J. 36, 3549-3551.
  17. Ulianov, S. V., Tachibana-Konwalski, K., Razin, S. V. (2017). Single-cell Hi-C bridges microscopy and genome-wide sequencing approaches to study 3D chromatin organization. BioEssays 39, 1700104.
  18. Flyamer, I.M.*, Gassler, J.*, Imakaev, M.*, Brandão, H.B., Ulianov, S. V., Abdennur, N., Razin, S. V., Mirny, L.A., Tachibana-Konwalski, K. (2017). Single-nucleus Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition. Nature 544, 110–114.
    • Research Highlight: Perdigoto, C. (2017). Nat. Rev. Genet. 18, 327.
    • Highlighted in: Akst, J. (2017). The Scientist. December, 28-35. Cover story.
    • Recommended in F1000 Prime as being of special significance in its field.
  19. Ladstätter, S., and Tachibana-Konwalski, K. (2016). A Surveillance Mechanism Ensures Repair of DNA Lesions during Zygotic Reprogramming. Cell 167, 1774–1787.
    • Preview: Zou, L. (2016). Cell 167, 1676- 1678.
    • Highlighted in: Akst, J. (2017). The Scientist. December, 28-35. Cover story.
    • 2016 Best Paper Award by the Austrian Academy of Sciences
  20. Burkhardt, S., Borsos, M., Szydlowska, A., Godwin, J., Williams, S.A., Cohen, P.E., Hirota, T., Saitou, M., Tachibana-Konwalski K. (2016). Chromosome cohesion established by Rec8-cohesin in fetal oocytes is maintained without detectable turnover in oocytes arrested for months in mice. Curr. Biol. 26, 678-685.
    • Dispatch: Toth, A., and Jessberger, R. (2016). Curr. Biol. 26, R329-R331.
  21. Prakash, K., Fournier, D., Redl, S., Best, G., Borsos, M., Tiwari, V.K., Tachibana-Konwalski, K., Ketting, R.F., Parekh, S.H., Cremer, C., Birk, U.J. (2015). Super-resolution imaging reveals structurally distinct periodic patterns of chromatin along pachytene chromosomes. Proc. Natl. Acad. Sci. USA 112, 14635-14640.
  22. Tachibana-Konwalski, K. (2014). Cell division: Hold on and let go. Nature 517, 441-442.
  23. Tachibana-Konwalski, K.,# Godwin, J., Borsos, M., Rattani, A., Adams, D.J., Nasmyth, K.# (2013). Spindle assembly checkpoint of oocytes depends on a kinetochore structure determined by cohesin in meiosis I. Curr. Biol. 23, 2534-2539.
    • Dispatch: Nagaoka, S.I. (2013). Curr. Biol. 23, R1105-R1108.
  24. Yang, V.S., Carter, S.A., Ng, Y., Hyland, S.J., Tachibana-Konwalski, K., Fisher, R.A., Sebire, N.J., Seckl, M.J., Pedersen, R.A., Laskey, R.A., Gonzalez, M.A. (2012). Distinct activities of the anaphase-promoting complex/cyclosome (APC/C) in mouse embryonic cells. Cell Cycle 11, 846-855.
  25. Tachibana-Konwalski, K. (2012). Pat(ting) boosts meiosis. Cell Cycle 11, 1876-1877.
  26. Seitan, V.C.,* Hao, B.,* Tachibana-Konwalski, K.,* Lavagnolli, T., Mira-Bontenbal, H., Brown, K.E., Teng, G., Carroll, T., Terry, A., Horan, K., Marks, H., Adams, D.J., Schatz, D.G., Aragon, L., Fisher, A.G., Krangel, M.S., Nasmyth, K., Merkenschlager, M. (2011). A role for cohesin in T cell receptor rearrangement and thymocyte differentiation. Nature 476, 467-471.
  27. Yang, V.S., Carter, S.A., Hyland, S.J., Tachibana-Konwalski, K., Laskey, R.A., Gonzalez, M.A. (2011). Geminin escapes degradation in G1 of mouse pluripotent cells and mediates the expression of oct4, sox2, and nanog. Curr. Biol. 21, 692-699.
  28. Tachibana-Konwalski, K., Godwin, J., van der Weyden, L., Champion, L., Kudo, N.R., Adams, D.J., Nasmyth, K. (2010). Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes. Genes Dev. 24, 2505-2516. Cover story.
    • Perspective: Jessberger, R. (2010). Genes Dev. 24, 2587-2591.
  29. Gonzalez, M.A.,* Tachibana, K.E.,* Adams, D.J.,* van der Weyden, L., Hemberger, M., Coleman, N., Bradley, A., Laskey, R.A. (2006). Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development. Genes Dev. 20, 1880-1884.
  30. Tachibana, K.,# and Nigg, E.A. (2006). Geminin regulates multiple steps of the chromosome inheritance cycle. Cell Cycle 5, 151-154.
  31. Tachibana, K.K.,# Gonzalez, M.A., Nigg, E.A., Laskey, R.A. (2005). Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects. EMBO Rep. 6, 1052-1047.
  32. Gonzalez, M.A., Tachibana, K.E., Laskey, R.A., Coleman, N. (2005). Control of DNA replication and its potential clinical exploitation. Nat. Rev. Cancer 5, 135-141.
  33. Tachibana, K.E.,# Gonzalez, M.A., Coleman, N. (2005). Cell-cycle-dependent regulation of DNA replication and its relevance to cancer pathology. J. Pathol. 205, 123-129.
  34. van der Weyden, L., Tachibana, K.K.,* Gonzalez, M.A.,* Adams, D.J.,* Ng, B.L., Petty, R., Venkitaraman, A.R., Arends, M.J., Bradley, A. (2005). The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumourigenesis. Mol. Cell Biol. 25, 8356-8367.
  35. Gonzalez, M.A.,* Tachibana, K.E.,* Chin, S.F., Callagy, G., Madine, M.A., Vowler, S.L., Pinder, S.E., Laskey, R.A., Coleman, N. (2004). Geminin predicts adverse clinical outcome in breast cancer by reflecting cell-cycle progression. J. Pathol. 204, 121-130.
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