Publications

Articles

(24) Lemke S. B., Weidemann T., Cost A. L., Grashoff C., Schnorrer F.: A small proportion of Talin molecules transmit forces at developing muscle attachments in vivo. PLoS Biol. (2019) 17: e3000057.

PubMed

(23) Steiert F., Petrov E. P., Schultz P., Schwille P., and Weidemann T.* (*Corresponding author): Photophysical behavior of mNeonGreen, an evolutionarily distant green fluorescent protein. Biophys. J. (2018), 114: 2419-2431.

PubMed

(22) Worch R., Petrásek Z., Schwille P., Weidemann T.* (*Corresponding author)Diffusion of single-pass transmembrane receptors: from the plasma membrane into giant liposomes. J. Membr. Biol. (2017) 250: 393-406.

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(21) Pylypenko O., Welz T., Tittel J., Kollmar M., Chardon F., Malherbe G., Weiss S., Michel C. I. , Samol-Wolf A., Grasskamp A. T., Hume A., Goud B., Baron B., England P., Titus M. A., Schwille P., Weidemann T., Houdusse A., and Kerkhoff E.Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes. eLIFE (2016) 5: e17523. 

PubMed

(20) Heusermann W., Wolf L., Pham N., Auer M., Weidemann T., and Hintersteiner M.: A wide field fluorescence microscope extension for ultrafast screening of one-bead one-compound libraries using a spectral image subtraction approach. ACS Comb. Sci. (2016) 18: 209-219.

PubMed

(19) Sánchez F. M., Levi V., Weidemann T.*, and Carrer D.* (*Corresponding authors): Agonist mobility on supported bilayers affects Fas mediated death response. FEBS Lett. (2015) 589: 3527-3533

PubMed

(18) Kurgonaite K.*, Gandhi H.*, Kurth T., Pautot S., Schwille P., Weidemann T.**, and Bökel C.** (*Equal contributions, **Corresponding authors): Essential role of endocytosis for Interleukin-4 receptor mediated JAK/STAT signalling. J. Cell. Sci. (2015) 128: 3781-3795. 

PubMed

(17) Tittel J., Welz T., Czogalla A., Dietrich S., Samol-Wolf A., Schulte M., Schwille P., Weidemann T.*, and Kerkhoff E.* (*Equal contributions): Membrane targeting of the Spir-Formin actin nucleator complex requires a sequential handshake of polar interactions. J. Biol. Chem. (2015) 290: 6428-6444. 

PubMed

(16) Gandhi H., Worch W., Kurgonaite K., Hintersteiner M., Schwille P., Bökel C., and Weidemann T.* (*Corresponding author): Dynamics and interaction of Interleukin-4 receptor subunits in living cells. Biophys. J. (2014) 107: 2515-2527.[Featured by Stefan N. Constantinescu: Gathering support for critical mass: Interleukin-4 Receptor signaling requires clustering in endosomes. Biophys. J. 107: 2479-2480.]

PubMed

(15) Weidemann T.*, Mücksch J., and Schwille P.* (*Corresponding authors): Fluorescence fluctuation microscopy: a diversified arsenal of methods to investigate molecular dynamics inside cells. Curr. Opin. Struct. Biol. (2014) 28: 69-76. 

PubMed

(14) Müller P., Schwille P., and Weidemann T.* (*Corresponding author): PyCorrFit—generic data evaluation for fluorescence correlation spectroscopy. Bioinformatics (2014) 30: 2532-33.

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(13) Kupinski A. P., Raabe I., Michel M., Ail D., Brusch L., Weidemann T., and Bökel C.: Phosphorylation of the Smo tail is controlled by membrane localisation and is dispensable for clustering. J. Cell Sci. (2013) 126: 4684-97.

PubMed

(12) Kotlarz D., Zietara N., Uzel G., Weidemann T., Braun C. J., Diestelhorst J., Krawitz P. M., Robinson P. N., Hecht J., Puchalka J., Gertz E. M., Schaffer A. A., Lawrence M. G., Kardava L., Pfeifer D., Baumann U., Pfister E. D., Hanson E. P., Schambach A., Jacobs R., Kreipe H., Moir S., Milner J. D., Schwille P., Mundlos S., and Klein C.: Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome. J. Exp. Med. (2013) 210: 433-43.

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(11) Weidemann T.*, Worch R., Kurgonaite K., Hintersteiner M., Bökel C., and Schwille P. (*Corresponding author): Single cell analysis of ligand binding and complex formation of interleukin-4 receptor subunits. Biophys. J. (2011) 101: 2360-9.

PubMed

(10) Worch R., Bökel C., Höfinger S., Schwille P., and  Weidemann T.(*Corresponding author): Focus on composition and interaction potential of single-pass transmembrane domains. Proteomics (2010) 10: 4196-208.

PubMed

(9) Weidemann T., Seifert J. M., Hintersteiner M., and Auer M.: Analysis of protein-small molecule interactions by microscale equilibrium dialysis and its application as a secondary confirmation method for on-bead screening. J. Comb. Chem. (2010) 12: 647-54.

PubMed

(8) Hintersteiner M., Kimmerlin T., Kalthoff F., Stoeckli M., Garavel G., Seifert J. M., Meisner N. C., Uhl V., Buehler C., Weidemann T., and Auer M.: Single bead labeling method for combining confocal fluorescence on-bead screening and solution validation of tagged one-bead one-compound libraries. Chem. Biol. (2009) 16: 724-35.

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(7) Kar P., Seel M., Weidemann T., and Höfinger S.: Theoretical mimicry of biomembranes. FEBS Lett. (2009) 583: 1909-15.

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(6) Hintersteiner M.*, Weidemann T.*, Kimmerlin T., Filiz N., Buehler, C., and Auer M. (*Equal contributions): Covalent fluorescence labeling of His-tagged proteins on the surface of living cells. Chembiochem (2008) 9: 1391-5. 

PubMed

(5) Weidemann T.*, Höfinger S., Müller K. , and Auer M.* (*Corresponding authors): Beyond Dimerization: A Membrane-dependent Activation Model for Interleukin-4 Receptor-mediated Signalling. J. Mol. Biol. (2007) 366: 1365-73.

PubMed

(4) Meisner N. C., Hintersteiner M., Uhl V., Weidemann T., Schmied M., Gstach H., and Auer M.: The chemical hunt for the identification of drugable targets. Curr. Opin. Chem. Biol. (2004) 8: 424-431.

PubMed

(3) Weidemann T., Wachsmuth M., Knoch T. A., Müller G., Waldeck W., and Langowski J.:  Counting nucleosomes in living cells with a combination of fluorescence correlation spectroscopy and confocal imaging. J. Mol. Biol. (2003) 334: 229-40.

PubMed

(2) Wachsmuth M., Weidemann T., Müller G., Hoffmann-Rohrer U. W., Knoch T. A., Waldeck,W., and Langowski J.: Analyzing intracellular binding and diffusion with continuous fluorescence photobleaching. Biophys. J. (2003) 84: 3353-63.

PubMed

(1) Weidemann T., Wachsmuth M., Tewes M., Rippe K., and Langowski J.: Analysis of Ligand Binding by Two-Colour Fluorescence Cross-Correlation Spectroscopy. Single Mol. (2002) 3: 49-61.

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Book Chapters

(7) Weidemann T.: Application of fluorescence correlation spectroscopy (FCS) to measure the dynamics of fluorescent proteins in living cells. Methods Mol. Biol. (2014) 1076: 539-55.

PubMed

(6) Müller P., Schwille P., and Weidemann T.* (*Corresponding author): Scanning fluorescence correlation spectroscopy (SFCS) with a scan path perpendicular to the membrane plane. Methods Mol. Biol. (2014) 1076: 635-51.

PubMed

(5) Weidemann T. & Schwille P.: Fluorescence cross-correlation spectroscopy. In Encyclopedia of Biophysics (2013), Roberts, G. C. K. ed., pp. 795-799. Springer, Berlin, Heidelberg.

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(4) Weidemann T.* & Schwille P.* (*Corresponding authors): Dual-color fluorescence cross-correlation spectroscopy with continuous laser excitation in a confocal setup. Methods Enzymol. (2013) 518: 43-70.

PubMed

(3) Ries J., Weidemann T., and Schwille, P.: Fluorescence Correlation Spectroscopy. Comprehensive Biophysics, Vol 2: Biophysical Techniques for Characterization of Cells (2011), pp. 210-245, Elsevier Academic Press, Oxford.

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(2) Weidemann T., Hoefinger S., and Auer M.: Signaling of IL-4R, a typical class I cytokine receptor: what defines the quiescent state? In Handbook of Cell Signalling (2009), Dennis, E. & Bradshaw, R., eds., 2nd edit, Vol. 1. 3 vols., Elsevier Press.

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(1) Weidemann T. & Schwille P.: Fluorescence Correlation Spectroscopy in Living Cells. Handbook of Single-Molecule Biophysics (2009), Hinterdorfer, P. & Van Oijen, A., eds., 1 vols, Springer, Heidelberg.

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Patents

(1) Patent Numbers: US2013084275-A1 (4. April 2013); US8771682-B2 (8. Juli 2014) ‘Reducing interleukin (IL)-4 or IL-13 signaling, comprises administering inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac) or serine or threonine p21-activated kinase (Pak) driven endocytosis’ Technische Universität Dresden, Inventors: Bökel C, Weidemann T.

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