Publications of Grzegorz M. Popowicz

Ammon, T.; Mishra, S. K.; Kowalska, K.; Popowicz, G. M.; Holak, T. A.; Jentsch, S.: The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells. JOURNAL OF MOLECULAR CELL BIOLOGY 6 (4), pp. 312 - 323 (2014)

Huang, Y.; Wolf, S.; Beck, B.; Koehler, L.-M.; Khoury, K.; Popowicz, G. M.; Goda, S. K.; Subklewe, M.; Twarda, A.; Holak, T. et al.; Domling, A.: Discovery of Highly Potent p53-MDM2 Antagonists and Structural Basis for Anti-Acute Myeloid Leukemia Activities. ACS CHEMICAL BIOLOGY 9 (3), pp. 802 - 811 (2014)

Burchacka, E.; Zdzalik, M.; Niemczyk, J.-S.; Pustelny, K.; Popowicz, G.; Wladyka, B.; Dubin, A.; Potempa, J.; Sienczyk, M.; Dubin, G. et al.; Oleksyszyn, J.: Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus. PROTEIN SCIENCE 23 (2), pp. 179 - 189 (2014)

Pustelny, K.; Zdzalik, M.; Stach, N.; Stec-Niemczyk, J.; Cichon, P.; Czarna, A.; Popowicz, G.; Mak, P.; Drag, M.; Salvesen, G. S. et al.; Wladyka, B.; Potempa, J.; Dubin, A.; Dubin, G.: Staphylococcal SplB Serine Protease Utilizes a Novel Molecular Mechanism of Activation. JOURNAL OF BIOLOGICAL CHEMISTRY 289 (22), pp. 15544 - 15553 (2014)

Baek, S.; Kang, N. J.; Popowicz, G. M.; Arciniega Castro, M.; Jung, S. K.; Byun, S.; Song, N. R.; Heo, Y.-S.; Kim, B. Y.; Lee, H. J. et al.; Holak, T. A.; Augustin, M.; Bode, A. M.; Huber, R.; Dong, Z.; Lee, K. W.: Structural and Functional Analysis of the Natural JNK1 Inhibitor Quercetagetin. JOURNAL OF MOLECULAR BIOLOGY 425 (2), pp. 411 - 423 (2013)

Bista, M.; Wolf, S.; Khoury, K.; Kowalska, K.; Huang, Y.; Wrona, E.; Arciniega, M.; Popowicz, G. M.; Holak, T.; Domling, A.: Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction. STRUCTURE 21 (12), pp. 2143 - 2151 (2013)

Koes, D.; Khoury, K.; Huang, Y. J.; Wang, W.; Bista, M.; Popowicz, G. M.; Wolf, S.; Holak, T. A.; Domling, A.; Camacho, C. J.: Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists. PLoS ONE 7 (3), e32839, pp. [1] - [8] (2012)

Baek, S.; Kutchukian, P. S.; Verdine, G. L.; Huber, R.; Holak, T. A.; Lee, K. W.; Popowicz, G. M.: Structure of the Stapled p53 Peptide Bound to Mdm2. Journal of the American Chemical Society 134 (1), pp. 103 - 106 (2012)

Huang, Y. J.; Wolf, S.; Koes, D.; Popowicz, G. M.; Camacho, C. J.; Holak, T. A.; Domling, A.: Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists. ChemMedChem 7 (1), pp. 49 - 52 (2012)

Mishra, S. K.; Ammon, T.; Popowicz, G. M.; Krajewski, M.; Nagel, R. J.; Ares, M.; Holak, T. A.; Jentsch, S.: Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing. Nature 474 (7350), pp. 173 - 178 (2011)

Khoury, K.; Popowicz, G. M.; Holak, T. A.; Domling, A.: The p53-MDM2/MDMX axis - A chemotype perspective. Medchemcomm 2 (4), pp. 246 - 260 (2011)

Popowicz, G. M.; Domling, A.; Holak, T. A.: The Structure-Based Design of Mdm2/Mdmx-p53 Inhibitors Gets Serious. Angewandte Chemie-International Edition 50 (12), pp. 2680 - 2688 (2011)

Ducka, A. M.; Joel, P.; Popowicz, G. M.; Trybus, K. M.; Schleicher, M.; Noegel, A. A.; Huber, R.; Holak, T. A.; Sitar, T.: Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proceedings of the National Academy of Sciences of the United States of America 107 (26), pp. 11757 - 11762 (2010)

Popowicz, G. M.; Czarna, A.; Wolf, S.; Wang, K.; Wang, W.; Domling, A.; Holak, T. A.: Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. Cell Cycle 9 (6), pp. 1104 - 1111 (2010)

Czarna, A.; Beck, B.; Srivastava, S.; Popowicz, G. M.; Wolf, S.; Huang, Y. J.; Bista, M.; Holak, T. A.; Domling, A.: Robust Generation of Lead Compounds for Protein-Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists. Angewandte Chemie-International Edition 49 (31), pp. 5352 - 5356 (2010)

Szwagierczak, A.; Antonenka, U.; Popowicz, G. M.; Sitar, T.; Holak, T. A.; Rakin, A.: Structures of the Arm-type Binding Domains of HPI and HAI7 Integrases. Journal of Biological Chemistry 284 (46), pp. 31664 - 31671 (2009)

Stec-Niemczyk, J.; Pustelny, K.; Kisielewska, M.; Bista, M.; Boulware, K. T.; Stiennicke, H. R.; Thogersen, I. B.; Daugherty, P. S.; Enghild, J. J.; Baczynski, K. et al.; Popowicz, G. M.; Dubin, A.; Potempa, J.; Dubin, G.: Structural and functional characterization of SplA, an exclusively specific protease of Staphylococcus aureus. Biochemical Journal 419, pp. 555 - 564 (2009)

Czarna, A.; Popowicz, G. M.; Pecak, A.; Wolf, S.; Dubin, G.; Holak, T. A.: High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle 8 (8), pp. 1176 - 1184 (2009)

Zuckerman, V.; Lenos, K.; Popowicz, G. M.; Silberman, I.; Grossman, T.; Marine, J. C.; Holak, T. A.; Jochemsen, A. G.; Haupt, Y.: c-Abl Phosphorylates Hdmx and Regulates Its Interaction with p53. Journal of Biological Chemistry 284 (6), pp. 4031 - 4039 (2009)

Rothweiler, U.; Czarna, A.; Weber, L.; Popowicz, G. M.; Brongel, K.; Kowalska, K.; Orth, M.; Stemmann, O.; Holak, T. A.: NMR screening for lead compounds using tryptophan-mutated proteins. Journal of Medicinal Chemistry 51 (16), pp. 5035 - 5042 (2008)