Publications of Dawafuti Sherpa

Gottemukkala, K. V.; Chrustowicz, J.; Sherpa, D.; Sepic, S.; Tung Vu, D.; Karayel, O.; Papadopoulou, E. C.; Gross, A.; Schorpp, K.; von Gronau, S. et al.; Hadian, K.; Murray, P. J.; Mann, M.; Schulman, B. A.; Alpi, A. F.: Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism. Molecular Cell 84 (10), pp. 1948 - 1963.e11 (2024)

Gross, A.; Müller, J.; Chrustowicz, J.; Strasser, A.; Gottemukkala, K. V.; Sherpa, D.; Schulman, B. A.; Murray, P. J.; Alpi, A. F.: Skraban-Deardorff intellectual disability syndrome-associated mutations in WDR26 impair CTLH E3 complex assembly. FEBS Letters 598 (9), pp. 978 - 994 (2024)

Chrustowicz, J.; Sherpa, D.; Li, J.; Langlois, C. R.; Papadopoulou, E. C.; Tung Vu, D.; Hehl, L. A.; Karayel, Ö.; Beier, V.; Gronau, S. v. et al.; Müller, J.; Prabu, J. R.; Mann, M.; Kleiger, G.; Alpi, A. F.; Schulman, B. A.: Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies. Molecular Cell 84 (2), pp. 293 - 308 (2024)

Sherpa, D.; Mueller, J.; Karayel, Ö.; Xu, P.; Yao, Y.; Chrustowicz, J.; Gottemukkala, K. V.; Baumann, C. A.; Gross, A.; Czarnecki, O. et al.; Zhang, W.; Gu, J.; Nilvebrant, J.; Sidhu, S. S.; Murray, P. J.; Mann, M.; Weiss, M. J.; Schulman, B. A.; Alpi, A. F.: Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation. eLife 11, e77937 (2022)

Langlois, C. R.; Beier, V.; Karayel, O.; Chrustowicz, J.; Sherpa, D.; Mann, M.; Schulman, B. A.: A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters. EMBO Reports 23 (6), e53835 (2022)

Qiao, S.; Lee, C.-W.; Sherpa, D.; Chrustowicz, J.; Cheng, J. D.; Duennebacke, M.; Steigenberger, B.; Karayel, O.; Tung Vu, D.; Gronau, S. v. et al.; Mann, M.; Wilfling, F.; Schulman, B.: Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation. Nature Communications 13 (1), 3041 (2022)

Sherpa, D.; Chrustowicz, J.; Schulman, B.: How the ends signal the end: Regulation by E3 ubiquitin ligases recognizing protein termini. Molecular Cell 82 (8), pp. 1424 - 1438 (2022)

Chrustowicz, J.; Sherpa, D.; Teyra, J.; Loke, M. S.; Popowicz, G. M.; Basquin, J.; Sattler, M.; Prabu, J. R.; Sidhu, S. S.; Schulman, B.: Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases. Journal of Molecular Biology 434 (2), 167347 (2022)

Sherpa, D.; Chrustowicz, J.; Qiao, S.; Langlois, C. R.; Hehl, L. A.; Gottemukkala, K. V.; Hansen, F. M.; Karayel, O.; von Gronau, S.; Prabu, J. R. et al.; Mann, M.; Alpi, A. F.; Schulman, B. A.: GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Molecular Cell 81 (11), pp. 2445 - 2459.e13 (2021)

Qiao, S.; Langlois, C. R.; Chrustowicz, J.; Sherpa, D.; Karayel, O.; Hansen, F. M.; Beier, V.; von Gronau, S.; Bollschweiler, D.; Schäfer, T. et al.; Alpi, A. F.; Mann, M.; Prabu, J. R.; Schulman, B.: Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly. MOLECULAR CELL 77 (1), pp. 150 - 163.e9 (2020)

Wilfling, F.; Lee, C.-W.; Erdmann, P. S.; Zheng, Y.; Sherpa, D.; Jentsch, S.; Pfander, B.; Schulman, B. A.; Baumeister, W.: A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits. Molecular Cell 80 (5), pp. 764 - 778.e7 (2020)

Langlois, C. R.; Qiao, S.; Sherpa, D.; Chrustowicz, J.; Beier, V.; Karayel, O.; Schulman, B.: The GID E3 Ubiquitin Ligase Converts Between Anticipatory and Active States Through the Incorporation of Swappable Substrate Receptors. In The FASEB Journal, 34, p. 1 - 1. Annual Meeting on Experimental Biology, San Diego, CA, April 04, 2020 - April 07, 2020. The Federation, Bethesda, Md. (2020)

Sherpa, D.: Structural and functional characterization of GID/CTLH E3 ubiquitin ligases. Dissertation, Technische Universität, Fakultät für Chemie, München (2022)

Sherpa, D.: Structural and functional characterization of novel E3 ubiquitin ligase, focusing on Proline/N-end rule pathway. Master, Ludwig-Maximilians Universität, Dep. of Cell and Developmental Biology, München (2018)