Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity Kalafati, L., I. Kourtzelis, J. Schulte-Schrepping, X. Li, A. Hatzioannou, T. Grinenko, E. Hagag, A. Sinha, C. Has, S. Dietz, A. M. de Jesus Domingues, M. Nati, S. Sormendi, A. Neuwirth, A. Chatzigeorgiou, A. Ziogas, M. Lesche, A. Dahl, I. Henry, P. Subramanian, B. Wielockx, P. Murray, P. Mirtschink, K. J. Chung, J. L. Schultze, M. G. Netea, G. Hajishengallis, P. Verginis, I. Mitroulis and T. Chavakis Cell  (2020) 183: 771-785 e712.

Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses Merlo, L. M. F., J. B. DuHadaway, J. D. Montgomery, W. D. Peng, P. J. Murray, G. C. Prendergast, A. J. Caton, A. J. Muller and L. Mandik-Nayak Front Immunol  (2020) 11: 1861.

Cancer metastasis linked to macrophage size, shape, and metabolism Murray, P. J. J Exp Med  (2020) 217

Cold non-ischemic heart preservation with continuous perfusion prevents early graft failure in orthotopic pig-to-baboon xenotransplantation Langin, M., B. Reichart, S. Steen, T. Sjoberg, A. Paskevicius, Q. Liao, G. Qin, M. Mokelke, T. Mayr, J. Radan, L. Issl, I. Buttgereit, J. Ying, A. K. Fresch, A. Panelli, S. Egerer, A. Bahr, B. Kessler, A. Milusev, R. Sfriso, R. Rieben, D. Ayares, P. J. Murray, R. Ellgass, C. Walz, N. Klymiuk, E. Wolf, J. M. Abicht and P. Brenner Xenotransplantation  (2020): e12636.

The Disabled homolog 2 controls pro-metastatic activity of tumor-associated macrophages Marigo, I., R. Trovato, F. Hofer, V. Ingangi, D. E. S. F, S. Ugel, S. Cane, A. Simonelli, A. Lamolinara, M. Iezzi, M. Fassan, M. Rugge, F. Boschi, G. Borile, T. Eisenhaure, S. Sarkizova, D. Lieb, N. Hacohen, L. Azzolin, S. Piccolo, R. Lawlor, A. Scarpa, L. Carbognin, E. Bria, S. Bicciato, P. J. Murray and V. Bronte Cancer Discov  (2020). 10: 1758.

Cutting Edge: TNF Is Essential for Mycobacteria-Induced MINCLE Expression, Macrophage Activation, and Th17 Adjuvanticity Schick, J., J. Schafer, C. Alexander, S. Dichtl, P. J. Murray, D. Christensen, U. Sorg, K. Pfeffer, U. Schleicher and R. Lang J Immunol  (2020) 205: 323-328.

Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal Baumann, T., A. Dunkel, C. Schmid, S. Schmitt, M. Hiltensperger, K. Lohr, V. Laketa, S. Donakonda, U. Ahting, B. Lorenz-Depiereux, J. E. Heil, J. Schredelseker, L. Simeoni, C. Fecher, N. Korber, T. Bauer, N. Huser, D. Hartmann, M. Laschinger, K. Eyerich, S. Eyerich, M. Anton, M. Streeter, T. Wang, B. Schraven, D. Spiegel, F. Assaad, T. Misgeld, H. Zischka, P. J. Murray, A. Heine, M. Heikenwälder, T. Korn, C. Dawid, T. Hofmann, P. A. Knolle and B. Hochst Nat Immunol  (2020) 21: 555-566.

Environmental arginine controls multinuclear giant cell metabolism and formation Brunner, J. S., L. Vulliard, M. Hofmann, M. Kieler, A. Lercher, A. Vogel, M. Russier, J. B. Bruggenthies, M. Kerndl, V. Saferding, B. Niederreiter, A. Junza, A. Frauenstein, C. Scholtysek, Y. Mikami, K. Klavins, G. Kronke, A. Bergthaler, J. J. O'Shea, T. Weichhart, F. Meissner, J. S. Smolen, P. Cheng, O. Yanes, J. Menche, P. J. Murray, O. Sharif, S. Bluml and G. Schabbauer Nat Commun  (2020)11: 431.

On macrophage diversity and inflammatory metabolic timers Murray, P. J. Nat Rev Immunol  (2020) 20: 89-90.


InsP6 binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complex Gat, Y., J. M. Schuller, M. Lingaraju, E. Weyher, F. Bonneau, M. Strauss, P. J. Murray and E. Conti Nat Struct Mol Biol  (2019) 26: 1089-1093.

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD Koehn, B. H., A. Saha, C. McDonald-Hyman, M. Loschi, G. Thangavelu, L. Ma, M. Zaiken, J. Dysthe, W. Krepps, J. Panthera, K. Hippen, S. C. Jameson, J. S. Miller, M. A. Cooper, C. J. Farady, T. Iwawaki, J. P. Ting, J. S. Serody, W. J. Murphy, G. R. Hill, P. J. Murray, V. Bronte, D. H. Munn, R. Zeiser and B. R. Blazar Blood  (2019) 134: 1670-1682.


Induction of immunosuppressive functions and NF-kappaB by FLIP in monocytes Fiore, A., S. Ugel, F. De Sanctis, S. Sandri, G. Fracasso, R. Trovato, S. Sartoris, S. Solito, S. Mandruzzato, F. Vascotto, K. L. Hippen, G. Mondanelli, U. Grohmann, G. Piro, C. Carbone, D. Melisi, R. T. Lawlor, A. Scarpa, A. Lamolinara, M. Iezzi, M. Fassan, S. Bicciato, B. R. Blazar, U. Sahin, P. J. Murray* and V. Bronte* Nat Commun  (2018) 9: 5193. *Co-senior authors

M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion Luo, Y., L. Shao, J. Chang, W. Feng, Y. L. Liu, M. H. Cottler-Fox, P. D. Emanuel, M. Hauer-Jensen, I. D. Bernstein, L. Liu, X. Chen, J. Zhou, P. J. Murray and D. Zhou Blood Adv  (2018) 2: 859-870.

Caspase-1 from Human Myeloid Derived Suppressor Cells Can Promote T-cell independent Tumor Proliferation Zeng, Q., J. Fu, M. Korrer, M. Gorbounov, P.J. Murray, D.M. Pardoll, D.L. Masica, and Y.J. Kim Cancer Immunol Res, 2018

Immune regulation by monocytes Murray, P. J. Semin Immunol  (2018) 35: 12-18.

Nonresolving macrophage-mediated inflammation in malignancy Murray, P. J. FEBS J  (2018) 285: 641-653.


Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment Steggerda, S. M., M. K. Bennett, J. Chen, E. Emberley, T. Huang, J. R. Janes, W. Li, A. L. MacKinnon, A. Makkouk, G. Marguier, P. J. Murray, S. Neou, A. Pan, F. Parlati, M. L. M. Rodriguez, L. A. Van de Velde, T. Wang, M. Works, J. Zhang, W. Zhang and M. I. Gross J Immunother Cancer  (2017) 5: 101.

T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions
Van de Velde, L.A., C. Subramanian, A.M. Smith, L. Barron, J.E. Qualls, G. Neale, A. Alfonso-Pecchio, S. Jackowski, C.O. Rock, T.A. Wynn, and P.J. Murray J Biol Chem, 2017. 292(1): p. 15-30

Macrophage Polarization Murray, P.J. Annu Rev Physiol, 2017. 79: p. 541-566


Proliferating Helper T Cells Require Rictor/mTORC2 Complex to Integrate Signals from Limiting Environmental Amino Acids Van de Velde, L.A. and P.J. Murray J Biol Chem, 2016. 291(50): p. 25815-25822

Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing Van de Velde, L.A., X.J. Guo, L. Barbaric, A.M. Smith, T.H. Oguin, 3rd, P.G. Thomas, and P.J. Murray Cell Rep, 2016. 17(9): p. 2247-2258

Issues with the Specificity of Immunological Reagents for Murine IDO1 Van de Velde, L.A., S. Gingras, S. Pelletier, and P.J. Murray Cell Metab, 2016. 23(3): p. 389-90

TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection Schleicher, U., K. Paduch, A. Debus, S. Obermeyer, T. Konig, J.C. Kling, E. Ribechini, D. Dudziak, D. Mougiakakos, P.J. Murray, R. Ostuni, H. Korner, and C. Bogdan Cell Rep, 2016. 15(5): p. 1062-1075

Immunometabolism within the tuberculosis granuloma: amino acids, hypoxia, and cellular respiration Qualls, J.E. and P.J. Murray Semin Immunopathol, 2016. 38(2): p. 139-52

Murray, P.J., IL-10, in Encyclopedia of Immunobiology, M.J.H. Ratcliffe, Editor. 2016, Academic Press. p. 544-553.

Amino acid auxotrophy as a system of immunological control nodes Murray, P.J. Nat Immunol, 2016. 17(2): p. 132-9

An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens Meliopoulos, V.A., L.A. Van de Velde, N.C. Van de Velde, E.A. Karlsson, G. Neale, P. Vogel, C. Guy, S. Sharma, S. Duan, S.L. Surman, B.G. Jones, M.D. Johnson, C. Bosio, L. Jolly, R.G. Jenkins, J.L. Hurwitz, J.W. Rosch, D. Sheppard, P.G. Thomas, P.J. Murray*, and S. Schultz-Cherry* PLoS Pathog, 2016. 12(8): p. e1005804 *Co-senior authors

T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells Marigo, I., S. Zilio, G. Desantis, B. Mlecnik, A.H. Agnellini, S. Ugel, M.S. Sasso, J.E. Qualls, F. Kratochvill, P. Zanovello, B. Molon, C.H. Ries, V. Runza, S. Hoves, A.M. Bilocq, G. Bindea, E.M. Mazza, S. Bicciato, J. Galon, P.J. Murray*, and V. Bronte* Cancer Cell, 2016. 30(3): p. 377-90 *Co-senior authors

Exogenous remodeling of lung resident macrophages protects against infectious consequences of bone marrow-suppressive chemotherapy Kamei, A., G. Gao, G. Neale, L.N. Loh, P. Vogel, P.G. Thomas, E.I. Tuomanen, and P.J. Murray Proc Natl Acad Sci U S A, 2016. 113(41): p. E6153-E6161

New insights into the multidimensional concept of macrophage ontogeny, activation and function Ginhoux, F., J.L. Schultze, P.J. Murray, J. Ochando, and S.K. Biswas Nat Immunol, 2016. 17(1): p. 34-40

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards Bronte, V., S. Brandau, S.H. Chen, M.P. Colombo, A.B. Frey, T.F. Greten, S. Mandruzzato, P.J. Murray, A. Ochoa, S. Ostrand-Rosenberg, P.C. Rodriguez, A. Sica, V. Umansky, R.H. Vonderheide, and D.I. Gabrilovich Nat Commun, 2016. 7: p. 12150


Macrophages and cancer: from mechanisms to therapeutic implications Ostuni, R., F. Kratochvill, P.J. Murray, and G. Natoli Trends Immunol, 2015. 36(4): p. 229-39

SnapShot: Immunometabolism Murray, P.J., J. Rathmell, and E. Pearce Cell Metab, 2015. 22(1): p. 190-190 e1

Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis Monin, L., K.L. Griffiths, W.Y. Lam, R. Gopal, D.D. Kang, M. Ahmed, A. Rajamanickam, A. Cruz-Lagunas, J. Zuniga, S. Babu, J.K. Kolls, M. Mitreva, B.A. Rosa, R. Ramos-Payan, T.E. Morrison, P.J. Murray, J. Rangel-Moreno, E.J. Pearce, and S.A. Khader J Clin Invest, 2015. 125(12): p. 4699-713

TNF Counterbalances the Emergence of M2 Tumor Macrophages Kratochvill, F., G. Neale, J.M. Haverkamp, L.A. Van de Velde, A.M. Smith, D. Kawauchi, J. McEvoy, M.F. Roussel, M.A. Dyer, J.E. Qualls, and P.J. Murray Cell Rep, 2015. 12(11): p. 1902-14

Tristetraprolin Limits Inflammatory Cytokine Production in Tumor-Associated Macrophages in an mRNA Decay-Independent Manner Kratochvill, F., N. Gratz, J.E. Qualls, L.A. Van De Velde, H. Chi, P. Kovarik, and P.J. Murray Cancer Res, 2015. 75(15): p. 3054-64

GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells Koehn, B.H., P. Apostolova, J.M. Haverkamp, J.S. Miller, V. McCullar, J. Tolar, D.H. Munn, W.J. Murphy, W.J. Brickey, J.S. Serody, D.I. Gabrilovich, V. Bronte, P.J. Murray*, J.P. Ting*, R. Zeiser*, and B.R. Blazar* Blood, 2015. 126(13): p. 1621-8 *Co-senior authors

Understanding local macrophage phenotypes in disease: modulating macrophage function to treat cancer Bronte, V. and P.J. Murray Nat Med, 2015. 21(2): p. 117-9


Arginase activity in alternatively activated macrophages protects PI3Kp110delta deficient mice from dextran sodium sulfate induced intestinal inflammation Weisser, S.B., L.K. Kozicky, H.K. Brugger, E.N. Ngoh, B. Cheung, R. Jen, S.C. Menzies, A. Samarakoon, P.J. Murray, C.J. Lim, P. Johnson, J.L. Boucher, N. van Rooijen, and L.M. Sly Eur J Immunol, 2014. 44(11): p. 3353-67

Helminth infection reactivates latent gamma-herpesvirus via cytokine competition at a viral promoter Reese, T.A., B.S. Wakeman, H.S. Choi, M.M. Hufford, S.C. Huang, X. Zhang, M.D. Buck, A. Jezewski, A. Kambal, C.Y. Liu, G. Goel, P.J. Murray, R.J. Xavier, M.H. Kaplan, R. Renne, S.H. Speck, M.N. Artyomov, E.J. Pearce, and H.W. Virgin Science, 2014. 345(6196): p. 573-7

Macrophage activation and polarization: nomenclature and experimental guidelines Murray, P.J., J.E. Allen, S.K. Biswas, E.A. Fisher, D.W. Gilroy, S. Goerdt, S. Gordon, J.A. Hamilton, L.B. Ivashkiv, T. Lawrence, M. Locati, A. Mantovani, F.O. Martinez, J.L. Mege, D.M. Mosser, G. Natoli, J.P. Saeij, J.L. Schultze, K.A. Shirey, A. Sica, J. Suttles, I. Udalova, J.A. van Ginderachter, S.N. Vogel, and T.A. Wynn Immunity, 2014. 41(1): p. 14-20

Obesity corrupts myelopoiesis Murray, P.J. Cell Metab, 2014. 19(5): p. 735-6

NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis Kobayashi, T., E.C. Steinbach, S.M. Russo, K. Matsuoka, T. Nochi, N. Maharshak, L.B. Borst, B. Hostager, J.V. Garcia-Martinez, P.B. Rothman, M. Kashiwada, S.Z. Sheikh, P.J. Murray, and S.E. Plevy J Immunol, 2014. 192(4): p. 1918-27

Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways Haverkamp, J.M., A.M. Smith, R. Weinlich, C.P. Dillon, J.E. Qualls, G. Neale, B. Koss, Y. Kim, V. Bronte, M.J. Herold, D.R. Green, J.T. Opferman, and P.J. Murray Immunity, 2014. 41(6): p. 947-59

Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas Duque-Correa, M.A., A.A. Kuhl, P.C. Rodriguez, U. Zedler, S. Schommer-Leitner, M. Rao, J. Weiner, 3rd, R. Hurwitz, J.E. Qualls, G.A. Kosmiadi, P.J. Murray, S.H. Kaufmann, and S.T. Reece Proc Natl Acad Sci U S A, 2014. 111(38): p. E4024-32

Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27 Bosmann, M., B. Strobl, N. Kichler, D. Rigler, J.J. Grailer, F. Pache, P.J. Murray, M. Muller, and P.A. Ward J Leukoc Biol, 2014. 96(1): p. 123-31

Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3 Bosmann, M., N.F. Russkamp, B. Strobl, J. Roewe, L. Balouzian, F. Pache, M.P. Radsak, N. van Rooijen, F.S. Zetoune, J.V. Sarma, G. Nunez, M. Muller, P.J. Murray, and P.A. Ward J Immunol, 2014. 193(11): p. 5668-77


Nicholson, S.E. and P.J. Murray, Regulation of macrophage polarization by the STAT-SOCS axis, in Macrophages: Biology and role in pathology of diseases, S.K. Biswas and A. Mantovani, Editors. 2013, Springer.

Generation of tissue-specific H-2Kd transgenic mice for the study of K(d)-restricted malaria epitope-specific CD8+ T-cell responses in vivo Huang, J., X. Li, K. Kohno, M. Hatano, T. Tokuhisa, P.J. Murray, T. Brocker, and M. Tsuji J Immunol Methods, 2013. 387(1-2): p. 254-61

Local arginase 1 activity is required for cutaneous wound healing Campbell, L., C.R. Saville, P.J. Murray, S.M. Cruickshank, and M.J. Hardman J Invest Dermatol, 2013. 133(10): p. 2461-70

Role of arginase 1 from myeloid cells in th2-dominated lung inflammation Barron, L., A.M. Smith, K.C. El Kasmi, J.E. Qualls, X. Huang, A. Cheever, L.A. Borthwick, M.S. Wilson, P.J. Murray, and T.A. Wynn PLoS One, 2013. 8(4): p. e61961


Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1 Zhao, Y., C. Alonso, I. Ballester, J.H. Song, S.Y. Chang, B. Guleng, S. Arihiro, P.J. Murray, R. Xavier, K.S. Kobayashi, and H.C. Reinecker Inflamm Bowel Dis, 2012. 18(4): p. 603-12

Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1 Qualls, J.E., C. Subramanian, W. Rafi, A.M. Smith, L. Balouzian, A.A. DeFreitas, K.A. Shirey, B. Reutterer, E. Kernbauer, S. Stockinger, T. Decker, I. Miyairi, S.N. Vogel, P. Salgame, C.O. Rock, and P.J. Murray Cell Host Microbe, 2012. 12(3): p. 313-23

Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways Murray, P.J. and S.T. Smale Nat Immunol, 2012. 13(10): p. 916-24

Non-canonical alternatives: what a macrophage is 4 Karp, C.L. and P.J. Murray J Exp Med, 2012. 209(3): p. 427-31

Adenosine promotes alternative macrophage activation via A2A and A2B receptors Csoka, B., Z. Selmeczy, B. Koscso, Z.H. Nemeth, P. Pacher, P.J. Murray, D. Kepka-Lenhart, S.M. Morris, Jr., W.C. Gause, S.J. Leibovich, and G. Hasko FASEB J, 2012. 26(1): p. 376-86

Agammaglobulinemia and absent B lineage cells in a patient lacking the p85alpha subunit of PI3K Conley, M.E., A.K. Dobbs, A.M. Quintana, A. Bosompem, Y.D. Wang, E. Coustan-Smith, A.M. Smith, E.E. Perez, and P.J. Murray J Exp Med, 2012. 209(3): p. 463-70

The composition and signaling of the IL-35 receptor are unconventional Collison, L.W., G.M. Delgoffe, C.S. Guy, K.M. Vignali, V. Chaturvedi, D. Fairweather, A.R. Satoskar, K.C. Garcia, C.A. Hunter, C.G. Drake, P.J. Murray, and D.A. Vignali Nat Immunol, 2012. 13(3): p. 290-9


A critical role for SOCS3 in innate resistance to Toxoplasma gondii Whitmarsh, R.J., C.M. Gray, B. Gregg, D.A. Christian, M.J. May, P.J. Murray, and C.A. Hunter Cell Host Microbe, 2011. 10(3): p. 224-36

A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3 Smith, A.M., J.E. Qualls, K. O'Brien, L. Balouzian, P.F. Johnson, S. Schultz-Cherry, S.T. Smale, and P.J. Murray J Biol Chem, 2011. 286(26): p. 23582-90

The role of IL-10 in immune regulation during M. tuberculosis infection Redford, P.S., P.J. Murray, and A. O'Garra Mucosal Immunol, 2011. 4(3): p. 261-70

Tumor macrophages protective and pathogenic roles in cancer development Qualls, J.E. and P.J. Murray Curr Top Dev Biol, 2011. 94: p. 309-28

Obstacles and opportunities for understanding macrophage polarization Murray, P.J. and T.A. Wynn J Leukoc Biol, 2011. 89(4): p. 557-63

Protective and pathogenic functions of macrophage subsets Murray, P.J. and T.A. Wynn Nat Rev Immunol, 2011. 11(11): p. 723-37

Gut Nod2 calls the bone marrow for monocyte reinforcements Murray, P.J. Immunity, 2011. 34(5): p. 693-5

Macrophages as a battleground for toxoplasma pathogenesis Murray, P.J. Cell Host Microbe, 2011. 9(6): p. 445-7

Interpreting mixed signals: the cell's cytokine conundrum Delgoffe, G.M., P.J. Murray, and D.A. Vignali Curr Opin Immunol, 2011. 23(5): p. 632-8

Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris Bowcutt, R., L.V. Bell, M. Little, J. Wilson, C. Booth, P.J. Murray, K.J. Else, and S.M. Cruickshank Parasite Immunol, 2011. 33(7): p. 411-20


STAT3 controls myeloid progenitor growth during emergency granulopoiesis Zhang, H., H. Nguyen-Jackson, A.D. Panopoulos, H.S. Li, P.J. Murray, and S.S. Watowich Blood, 2010. 116(14): p. 2462-71

Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling Qualls, J.E., G. Neale, A.M. Smith, M.S. Koo, A.A. DeFreitas, H. Zhang, G. Kaplan, S.S. Watowich, and P.J. Murray Sci Signal, 2010. 3(135): p. ra62

A double agent in cancer: stopping macrophages wounds tumors Qualls, J.E. and P.J. Murray Nat Med, 2010. 16(8): p. 863-4

IL-10 inhibits miR-155 induction by toll-like receptors McCoy, C.E., F.J. Sheedy, J.E. Qualls, S.L. Doyle, S.R. Quinn, P.J. Murray, and L.A. O'Neill J Biol Chem, 2010. 285(27): p. 20492-8


LAG-3 regulates plasmacytoid dendritic cell homeostasis Workman, C.J., Y. Wang, K.C. El Kasmi, D.M. Pardoll, P.J. Murray, C.G. Drake, and D.A. Vignali J Immunol, 2009. 182(4): p. 1885-91

Endogenous suppression of mast cell development and survival by IL-4 and IL-10 Speiran, K., D.P. Bailey, J. Fernando, M. Macey, B. Barnstein, M. Kolawole, D. Curley, S.S. Watowich, P.J. Murray, C. Oskeritzian, and J.J. Ryan J Leukoc Biol, 2009. 85(5): p. 826-36

Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity Schreiber, T., S. Ehlers, L. Heitmann, A. Rausch, J. Mages, P.J. Murray, R. Lang, and C. Holscher J Immunol, 2009. 183(2): p. 1301-12

Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10 Schaljo, B., F. Kratochvill, N. Gratz, I. Sadzak, I. Sauer, M. Hammer, C. Vogl, B. Strobl, M. Muller, P.J. Blackshear, V. Poli, R. Lang, P.J. Murray, and P. Kovarik J Immunol, 2009. 183(2): p. 1197-206

Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis Pesce, J.T., T.R. Ramalingam, M.M. Mentink-Kane, M.S. Wilson, K.C. El Kasmi, A.M. Smith, R.W. Thompson, A.W. Cheever, P.J. Murray*, and T.A. Wynn* PLoS Pathog, 2009. 5(4): p. e1000371 *Co-senior authors

Beyond peptidoglycan for Nod2 Murray, P.J. Nat Immunol, 2009. 10(10): p. 1053-4

Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival Lamkanfi, M., L.O. Moreira, P. Makena, D.C. Spierings, K. Boyd, P.J. Murray, D.R. Green, and T.D. Kanneganti Blood, 2009. 113(12): p. 2742-5

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification Huang, D.T., O. Ayrault, H.W. Hunt, A.M. Taherbhoy, D.M. Duda, D.C. Scott, L.A. Borg, G. Neale, P.J. Murray, M.F. Roussel, and B.A. Schulman Mol Cell, 2009. 33(4): p. 483-95

Role of the cytoplasmic pattern recognition receptor Nod2 in Coxiella burnetii infection Benoit, M., Y. Bechah, C. Capo, P.J. Murray, J.L. Mege, and B. Desnues Clin Microbiol Infect, 2009. 15 Suppl 2: p. 154-5


Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis Watanabe, T., N. Asano, P.J. Murray, K. Ozato, P. Tailor, I.J. Fuss, A. Kitani, and W. Strober J Clin Invest, 2008. 118(2): p. 545-59

Cytokine signaling modules in inflammatory responses O'Shea, J.J. and P.J. Murray Immunity, 2008. 28(4): p. 477-87

Modulation of adaptive immunity by different adjuvant-antigen combinations in mice lacking Nod2 Moreira, L.O., A.M. Smith, A.A. DeFreitas, J.E. Qualls, K.C. El Kasmi, and P.J. Murray Vaccine, 2008. 26(46): p. 5808-13

The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls Moreira, L.O., K.C. El Kasmi, A.M. Smith, D. Finkelstein, S. Fillon, Y.G. Kim, G. Nunez, E. Tuomanen, and P.J. Murray Cell Microbiol, 2008. 10(10): p. 2067-77

Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling Meyer, U., P.J. Murray, A. Urwyler, B.K. Yee, M. Schedlowski, and J. Feldon Mol Psychiatry, 2008. 13(2): p. 208-21

Persistent Coxiella burnetii infection in mice overexpressing IL-10: an efficient model for chronic Q fever pathogenesis Meghari, S., Y. Bechah, C. Capo, H. Lepidi, D. Raoult, P.J. Murray, and J.L. Mege PLoS Pathog, 2008. 4(2): p. e23

The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza McCullers, J.A., A.R. Iverson, R. McKeon, and P.J. Murray Scand J Infect Dis, 2008. 40(1): p. 11-7

IL-10 suppresses mast cell IgE receptor expression and signaling in vitro and in vivo Kennedy Norton, S., B. Barnstein, J. Brenzovich, D.P. Bailey, M. Kashyap, K. Speiran, J. Ford, D. Conrad, S. Watowich, M.R. Moralle, C.L. Kepley, P.J. Murray, and J.J. Ryan J Immunol, 2008. 180(5): p. 2848-54

Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens El Kasmi, K.C., J.E. Qualls, J.T. Pesce, A.M. Smith, R.W. Thompson, M. Henao-Tamayo, R.J. Basaraba, T. Konig, U. Schleicher, M.S. Koo, G. Kaplan, K.A. Fitzgerald, E.I. Tuomanen, I.M. Orme, T.D. Kanneganti, C. Bogdan, T.A. Wynn*, and P.J. Murray* Nat Immunol, 2008. 9(12): p. 1399-406 *Co-senior authors

Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival Cruickshank, S.M., L. Wakenshaw, J. Cardone, P.D. Howdle, P.J. Murray, and S.R. Carding World J Gastroenterol, 2008. 14(38): p. 5834-41

Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms Agarwal, R.K., R. Horai, A.M. Viley, P.B. Silver, R.S. Grajewski, S.B. Su, A.T. Yazdani, W. Zhu, M. Kronenberg, P.J. Murray, R.L. Rutschman, C.C. Chan, and R.R. Caspi J Immunol, 2008. 180(8): p. 5423-9


The JAK-STAT signaling pathway: input and output integration Murray, P.J. J Immunol, 2007. 178(5): p. 2623-9

Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis Gandotra, S., S. Jang, P.J. Murray, P. Salgame, and S. Ehrt Infect Immun, 2007. 75(11): p. 5127-34

Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway El Kasmi, K.C., A.M. Smith, L. Williams, G. Neale, A.D. Panopoulos, S.S. Watowich, H. Hacker, B.M. Foxwell, and P.J. Murray J Immunol, 2007. 179(11): p. 7215-9

Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling Dickensheets, H., N. Vazquez, F. Sheikh, S. Gingras, P.J. Murray, J.J. Ryan, and R.P. Donnelly Genes Immun, 2007. 8(1): p. 21-7


Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling Zimmermann, S., P.J. Murray, K. Heeg, and A.H. Dalpke J Immunol, 2006. 176(3): p. 1840-7

IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain Zhang, L., D.B. Badgwell, J.J. Bevers, 3rd, K. Schlessinger, P.J. Murray, D.E. Levy, and S.S. Watowich Mol Cell Biochem, 2006. 288(1-2): p. 179-89

Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis Watanabe, T., A. Kitani, P.J. Murray, Y. Wakatsuki, I.J. Fuss, and W. Strober Immunity, 2006. 25(3): p. 473-85

Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation Vats, D., L. Mukundan, J.I. Odegaard, L. Zhang, K.L. Smith, C.R. Morel, R.A. Wagner, D.R. Greaves, P.J. Murray, and A. Chawla Cell Metab, 2006. 4(1): p. 13-24

IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2 Totemeyer, S., M. Sheppard, A. Lloyd, D. Roper, C. Dowson, D. Underhill, P. Murray, D. Maskell, and C. Bryant J Immunol, 2006. 176(8): p. 4804-10

Signalling pathways and molecular interactions of NOD1 and NOD2 Strober, W., P.J. Murray, A. Kitani, and T. Watanabe Nat Rev Immunol, 2006. 6(1): p. 9-20

STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils Panopoulos, A.D., L. Zhang, J.W. Snow, D.M. Jones, A.M. Smith, K.C. El Kasmi, F. Liu, M.A. Goldsmith, D.C. Link, P.J. Murray, and S.S. Watowich Blood, 2006. 108(12): p. 3682-90

Cell wall-mediated neuronal damage in early sepsis Orihuela, C.J., S. Fillon, S.H. Smith-Sielicki, K.C. El Kasmi, G. Gao, K. Soulis, A. Patil, P.J. Murray, and E.I. Tuomanen Infect Immun, 2006. 74(7): p. 3783-9

Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response Murray, P.J. Curr Opin Pharmacol, 2006. 6(4): p. 379-86

Targeting vector construction by yeast artificial chromosome modification Murray, P.J. Methods Mol Biol, 2006. 349: p. 127-37

STAT3-mediated anti-inflammatory signalling Murray, P.J. Biochem Soc Trans, 2006. 34(Pt 6): p. 1028-31

Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development Kasper, L.H., T. Fukuyama, M.A. Biesen, F. Boussouar, C. Tong, A. de Pauw, P.J. Murray, J.M. van Deursen, and P.K. Brindle Mol Cell Biol, 2006. 26(3): p. 789-809

Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology Fillon, S., K. Soulis, S. Rajasekaran, H. Benedict-Hamilton, J.N. Radin, C.J. Orihuela, K.C. El Kasmi, G. Murti, D. Kaushal, M.W. Gaber, J.R. Weber, P.J. Murray, and E.I. Tuomanen J Immunol, 2006. 177(9): p. 6182-91

General nature of the STAT3-activated anti-inflammatory response El Kasmi, K.C., J. Holst, M. Coffre, L. Mielke, A. de Pauw, N. Lhocine, A.M. Smith, R. Rutschman, D. Kaushal, Y. Shen, T. Suda, R.P. Donnelly, M.G. Myers, Jr., W. Alexander, D.A. Vignali, S.S. Watowich, M. Ernst, D.J. Hilton, and P.J. Murray J Immunol, 2006. 177(11): p. 7880-8

Interleukin-10 induces apoptosis in developing mast cells and macrophages Bailey, D.P., M. Kashyap, L.A. Bouton, P.J. Murray, and J.J. Ryan J Leukoc Biol, 2006. 80(3): p. 581-9


beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae Radin, J.N., C.J. Orihuela, G. Murti, C. Guglielmo, P.J. Murray, and E.I. Tuomanen Infect Immun, 2005. 73(12): p. 7827-35

The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription Murray, P.J. Proc Natl Acad Sci U S A, 2005. 102(24): p. 8686-91

NOD proteins: an intracellular pathogen-recognition system or signal transduction modifiers? Murray, P.J. Curr Opin Immunol, 2005. 17(4): p. 352-8

Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway Manca, C., L. Tsenova, S. Freeman, A.K. Barczak, M. Tovey, P.J. Murray, C. Barry, and G. Kaplan J Interferon Cytokine Res, 2005. 25(11): p. 694-701

Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10 Hammer, M., J. Mages, H. Dietrich, F. Schmitz, F. Striebel, P.J. Murray, H. Wagner, and R. Lang Eur J Immunol, 2005. 35(10): p. 2991-3001

IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages Butcher, B.A., L. Kim, A.D. Panopoulos, S.S. Watowich, P.J. Murray, and E.Y. Denkers J Immunol, 2005. 174(6): p. 3148-52

WASP- mice exhibit defective immune responses to influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG Andreansky, S., H. Liu, S. Turner, J.A. McCullers, R. Lang, R. Rutschman, P.C. Doherty, P.J. Murray, A.W. Nienhuis, and T.S. Strom Exp Hematol, 2005. 33(4): p. 443-51


NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses Watanabe, T., A. Kitani, P.J. Murray, and W. Strober Nat Immunol, 2004. 5(8): p. 800-8

IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism Stockinger, S., B. Reutterer, B. Schaljo, C. Schellack, S. Brunner, T. Materna, M. Yamamoto, S. Akira, T. Taniguchi, P.J. Murray, M. Muller, and T. Decker J Immunol, 2004. 173(12): p. 7416-25

Enhancer-mediated control of macrophage-specific arginase I expression Pauleau, A.L., R. Rutschman, R. Lang, A. Pernis, S.S. Watowich, and P.J. Murray J Immunol, 2004. 172(12): p. 7565-73

Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling Gingras, S., E. Parganas, A. de Pauw, J.N. Ihle, and P.J. Murray J Biol Chem, 2004. 279(52): p. 54702-7


Role of nod2 in the response of macrophages to toll-like receptor agonists Pauleau, A.L. and P.J. Murray Mol Cell Biol, 2003. 23(21): p. 7531-9

SOCS3 regulates the plasticity of gp130 signaling Lang, R., A.L. Pauleau, E. Parganas, Y. Takahashi, J. Mages, J.N. Ihle, R. Rutschman, and P.J. Murray Nat Immunol, 2003. 4(6): p. 546-50

Fluconazole toxicity is independent of oxidative stress and apoptotic effector mechanisms in Saccharomyces cerevisiae Kontoyiannis, D.P. and P.J. Murray Mycoses, 2003. 46(5-6): p. 183-6


Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter Lang, R., R.L. Rutschman, D.R. Greaves, and P.J. Murray J Immunol, 2002. 168(7): p. 3402-11

Shaping gene expression in activated and resting primary macrophages by IL-10 Lang, R., D. Patel, J.J. Morris, R.L. Rutschman, and P.J. Murray J Immunol, 2002. 169(5): p. 2253-63


Yeast artificial chromosome targeting technology: an approach for the deletion of genes in the C57BL/6 mouse Wilson, C.J., C. Guglielmo, N.D. Moua, M. Tudor, G. Grosveld, R.A. Young, and P.J. Murray Anal Biochem, 2001. 296(2): p. 270-8

Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production Rutschman, R., R. Lang, M. Hesse, J.N. Ihle, T.A. Wynn, and P.J. Murray J Immunol, 2001. 166(4): p. 2173-7

Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus Braun, J.S., R. Novak, P.J. Murray, C.M. Eischen, S.A. Susin, G. Kroemer, A. Halle, J.R. Weber, E.I. Tuomanen, and J.L. Cleveland J Infect Dis, 2001. 184(10): p. 1300-9

TNF-alpha controls intracellular mycobacterial growth by both inducible nitric oxide synthase-dependent and inducible nitric oxide synthase-independent pathways Bekker, L.G., S. Freeman, P.J. Murray, B. Ryffel, and G. Kaplan J Immunol, 2001. 166(11): p. 6728-34

Last Millenium

Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors Wang, D., J. Feng, R. Wen, J.C. Marine, M.Y. Sangster, E. Parganas, A. Hoffmeyer, C.W. Jackson, J.L. Cleveland, P.J. Murray, and J.N. Ihle Immunity, 2000. 13(1): p. 25-35

Aerosol infection of mice with recombinant BCG secreting murine IFN-gamma partially reconstitutes local protective immunity Moreira, A.L., L. Tsenova, P.J. Murray, S. Freeman, A. Bergtold, L. Chiriboga, and G. Kaplan Microb Pathog, 2000. 29(3): p. 175-85

Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice Tudor, M., P.J. Murray, C. Onufryk, R. Jaenisch, and R.A. Young Genes Dev, 1999. 13(18): p. 2365-8

Increased antimycobacterial immunity in interleukin-10-deficient mice Murray, P.J. and R.A. Young Infect Immun, 1999. 67(6): p. 3087-95

Defining the requirements for immunological control of mycobacterial infections Murray, P.J. Trends Microbiol, 1999. 7(9): p. 366-72

Pneumolysin, a protein toxin of Streptococcus pneumoniae, induces nitric oxide production from macrophages Braun, J.S., R. Novak, G. Gao, P.J. Murray, and J.L. Shenep Infect Immun, 1999. 67(8): p. 3750-6

Hematopoietic remodeling in interferon-gamma-deficient mice infected with mycobacteria Murray, P.J., R.A. Young, and G.Q. Daley Blood, 1998. 91(8): p. 2914-24

Secretion of mammalian proteins from mycobacteria Murray, P.J. and R.A. Young Methods Mol Biol, 1998. 101: p. 275-84

T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection Murray, P.J., L. Wang, C. Onufryk, R.I. Tepper, and R.A. Young J Immunol, 1997. 158(1): p. 315-21

Manipulation and potentiation of antimycobacterial immunity using recombinant bacille Calmette-Guerin strains that secrete cytokines Murray, P.J., A. Aldovini, and R.A. Young Proc Natl Acad Sci U S A, 1996. 93(2): p. 934-9

A mammalian SRB protein associated with an RNA polymerase II holoenzyme Chao, D.M., E.L. Gadbois, P.J. Murray, S.F. Anderson, M.S. Sonu, J.D. Parvin, and R.A. Young Nature, 1996. 380(6569): p. 82-5

Epitope tagging of the human endoplasmic reticulum HSP70 protein, BiP, to facilitate analysis of BiP--substrate interactions Murray, P.J., S.S. Watowich, H.F. Lodish, R.A. Young, and D.J. Hilton Anal Biochem, 1995. 229(2): p. 170-9

Human stress protein hsp70: overexpression in E coli, purification and characterization Jindal, S., P. Murray, S. Rosenberg, R.A. Young, and K.P. Williams Biotechnology (N Y), 1995. 13(10): p. 1105-9

Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor Hilton, D.J., S.S. Watowich, P.J. Murray, and H.F. Lodish Proc Natl Acad Sci U S A, 1995. 92(1): p. 190-4

Characterization of a polymorphic family of integral membrane proteins in promastigotes of different Leishmania species Symons, F.M., P.J. Murray, H. Ji, R.J. Simpson, A.H. Osborn, R. Cappai, and E. Handman Mol Biochem Parasitol, 1994. 67(1): p. 103-13

Identification, characterisation and genomic cloning of a O-linked N-acetylglucosamine-containing cytoplasmic Leishmania glycoprotein Handman, E., L.D. Barnett, A.H. Osborn, J.W. Goding, and P.J. Murray Mol Biochem Parasitol, 1993. 62(1): p. 61-72

A simple purification of procyclic acidic repetitive protein and demonstration of a sialylated glycosyl-phosphatidylinositol membrane anchor Ferguson, M.A., P. Murray, H. Rutherford, and M.J. McConville Biochem J, 1993. 291 ( Pt 1): p. 51-5

Stress and immunological recognition in host-pathogen interactions Murray, P.J. and R.A. Young J Bacteriol, 1992. 174(13): p. 4193-6

Variants of a Leishmania surface antigen derived from a multigenic family Murray, P.J. and T.W. Spithill J Biol Chem, 1991. 266(36): p. 24477-84

Structure-function studies of human interferons-alpha: enhanced activity on human and murine cells Cheetham, B.F., B. McInnes, T. Mantamadiotis, P.J. Murray, P. Alin, P. Bourke, A.W. Linnane, and M.J. Tymms Antiviral Res, 1991. 15(1): p. 27-39

Leishmania major: expression and gene structure of the glycoprotein 63 molecule in virulent and avirulent clones and strains Murray, P.J., E. Handman, T.A. Glaser, and T.W. Spithill Exp Parasitol, 1990. 71(3): p. 294-304

Characterization of integral membrane proteins of Leishmania major by Triton X-114 fractionation and analysis of vaccination effects in mice Murray, P.J., T.W. Spithill, and E. Handman Infect Immun, 1989. 57(7): p. 2203-9

The PSA-2 glycoprotein complex of Leishmania major is a glycosylphosphatidylinositol-linked promastigote surface antigen Murray, P.J., T.W. Spithill, and E. Handman J Immunol, 1989. 143(12): p. 4221-6

Effect of unilateral cryptorchidism on the intertubular tissue of the adult rat testis: evidence for intracellular changes within the Leydig cells Kerr, J.B., G.P. Risbridger, P.J. Murray, and C.M. Knell Int J Androl, 1988. 11(3): p. 209-23

Rapid nucleotide sequence analysis of the small subunit ribosomal RNA of Toxoplasma gondii: evolutionary implications for the Apicomplexa Johnson, A.M., P.J. Murray, S. Illana, and P.J. Baverstock Mol Biochem Parasitol, 1987. 25(3): p. 239-46


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