Publications of T. A. Holak

Khaire, N.; Muller, R.; Blau-Wasser, R.; Eichinger, L.; Schleicher, M.; Rief, M.; Holak, T. A.; Noegel, A. A.: Filamin-regulated F-actin assembly is essential for morphogenesis and controls phototaxis in Dictyostelium. Journal of Biological Chemistry 282 (3), pp. 1948 - 1955 (2007)

Verdoodt, B.; Benzinger, A.; Popowicz, G. M.; Holak, T. A.; Hermeking, H.: Characterization of 14-3-3sigma dimerization determinants. Cell Cycle 5 (24), pp. 2920 - 2926 (2006)

Singh, M.; D'Silva, L.; Holak, T. A.: DNA-binding properties of the recombinant high-mobility-group-like AT- hook-containing region from human BRG1 protein. Biological Chemistry 387 (10-11), pp. 1469 - 1478 (2006)

Popowicz, G. M.; Schleicher, M.; Noegel, A. A.; Holak, T. A.: Filamins: promiscuous organizers of the cytoskeleton. Trends in Biochemical Sciences 31 (7), pp. 411 - 419 (2006)

Mikolajka, A.; Yan, X. M.; Popowicz, G. M.; Smialowski, P.; Nigg, E. A.; Holak, T. A.: Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. Journal of Molecular Biology 359 (4), pp. 863 - 875 (2006)

Popowicz, G. M.; Dubin, G.; Stec-Niemczyk, J.; Czarny, A.; Dubin, A.; Potempa, J.; Holak, T. A.: Functional and structural characterization of Spl proteases from Staphylococcus aureus. Journal of Molecular Biology 358 (1), pp. 270 - 279 (2006)

Joy, J.; Nalabothula, N.; Ghosh, M.; Popp, O.; Jochum, M.; Machleidt, W.; Gil-Parrado, S.; Holak, T. A.: Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d). Biological Chemistry 387 (3), pp. 329 - 335 (2006)

Sitar, T.; Popowicz, G. M.; Siwanowicz, I.; Huber, R.; Holak, T.: Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. Proceedings of the National Academie of Sciences 103, pp. 13028 - 13033 (2006)

Singh, M.; Krajewski, M.; Mikolajka, A.; Holak, T. A.: Molecular determinants for the complex formation between the retinoblastoma protein and LXCXE sequences. Journal of Biological Chemistry 280 (45), pp. 37868 - 37876 (2005)

Krajewski, M.; Ozdowy, P.; D'Silva, L.; Rothweiler, U.; Holak, T. A.: NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro. Nature Medicine 11 (11), pp. 1135 - 1136 (2005)

Arolas, J. L.; Popowicz, G. M.; Bronsoms, S.; Aviles, F. X.; Huber, R.; Holak, T. A.; Ventura, S.: Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: Contribution of the fourth disulfide bond. Journal of Molecular Biology 352 (4), pp. 961 - 975 (2005)

D'Silva, L.; Ozdowy, P.; Krajewski, M.; Rothweiler, U.; Singh, M.; Holak, T. A.: Monitoring the effects of antagonists on protein-protein interactions with NMR spectroscopy. Journal of the American Chemical Society 127 (38), pp. 13220 - 13226 (2005)

Arolas, J. L.; D'Silva, L.; Popowicz, G. M.; Aviles, F. X.; Holak, T. A.; Ventura, S.: NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor. Structure 13 (8), pp. 1193 - 1202 (2005)

Arolas, J. L.; Popowicz, G. M.; Lorenzo, J.; Sornmerhoff, C. P.; Huber, R.; Aviles, F. X.; Holak, T. A.: The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode. Journal of Molecular Biology 350 (3), pp. 489 - 498 (2005)

Arolas, J. L.; Popowicz, G.; Lorenzo, J.; Holak, T. A.; Sommerhoff, C. P.; Aviles, F. X.: Structural and functional characterization of a novel carboxypeptidase inhibitor from ticks. FEBS Journal 272 (Suppl. Suppl. 1), p. 361 - 361 (2005)

Smialowski, P.; Singh, M.; Mikolajka, A.; Majumdar, S.; Joy, J. K.; Nalabothula, N.; Krajewski, M.; Degenkolbe, R.; Bernard, H. U.; Holak, T. A.: NMR and mass spectrometry studies of putative interactions of cell cycle proteins pRb and CDK6 with cell differentiation proteins MyoD and ID-2. Biochimica et Biophysica Acta-Proteins and Proteomics 1750 (1), pp. 48 - 60 (2005)

Benzinger, A.; Popowicz, G. M.; Joy, J. K.; Majumdar, S.; Holak, T. A.; Hermeking, H.: The crystal structure of the non-liganded 14-3-3 sigma protein: insights into determinants of isoform specific ligand binding and dimerization. Cell Research 15 (4), pp. 219 - 227 (2005)

Ghosh, M.; Shanker, S.; Siwanowicz, I.; Mann, K.; Machleidt, W.; Holak, T. A.: Proteolysis of insulin-like growth factor binding proteins (IGFBPs) by calpain. Biological Chemistry 386, pp. 85 - 93 (2005)

Siwanowicz, I.; Popowicz, G. M.; Wisniewska, M.; Huber, R.; Kuenkele, K. P.; Lang, K.; Engh, R. A.; Holak, T. A.: Structural basis for the regulation of insulin-like growth factors by IGF binding proteins. Structure 13 (1), pp. 155 - 167 (2005)

Popowicz, G. M.; Muller, R.; Noegel, A. A.; Schleicher, M.; Huber, R.; Holak, T. A.: Molecular structure of the rod domain of Dictyostelium filamin. Journal of Molecular Biology 342 (5), pp. 1637 - 1646 (2004)