Publications of Fabien Bonneau

Bonneau, F.; Basquin, J.; Steigenberger, B.; Schäfer, T.; Schäfer, I. B.; Conti, E.: Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions. Genes & Development 37, pp. 505 - 517 (2023)

Gerlach, P.; Garland, W.; Lingaraju, M.; Salerno-Kochan, A.; Bonneau, F.; Basquin, J.; Jensen, T. H.; Conti, E.: Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Molecular Cell 82 (13), pp. 2505 - 2518 (2022)

Kögel, A.; Keidel, A.; Bonneau, F.; Schaefer, I.; Conti, E.: The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism. Molecular Cell 82 (4), pp. 756 - 769 (2022)

Langer, L. M.; Bonneau, F.; Gat, Y.; Conti, E.: Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8. eLife 10, e72353 (2021)

Langer, L. M.; Gat, Y.; Bonneau, F.; Conti, E.: Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity. ELIFE 9, e57127 (2020)

Schuller, S. K.; Schuller, J. M.; Prabu, J. R.; Baumgärtner, M.; Bonneau, F.; Basquin, J.; Conti, E.: Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex. eLife 9, e61467 (2020)

Gat, Y.; Schuller, J. M.; Lingaraju, M.; Weyher, E.; Bonneau, F.; Strauss, M.; Murray, P. J.; Conti, E.: InsP(6) binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complex. Nature Structural and Molecular Biology 26 (12), pp. 1089 - 1093 (2019)

Lingaraju, M.; Schuller, J. M.; Falk, S.; Gerlach, P.; Bonneau, F.; Basquin, J.; Benda, C.; Conti, E.: To Process or to Decay: A Mechanistic View of the Nuclear RNA Exosome. Cold Spring Harbor Symposia on Quantitative Biology 84, pp. 155 - 163 (2019)

Gerlach, P.; Schuller, J. M.; Bonneau, F.; Basquin, J.; Reichelt, P.; Falk, S.; Conti, E.: Distinct and evolutionary conserved structural features of the human nuclear exosome complex. eLife 7, e38686 (2018)

Gowravaram, M.; Bonneau, F.; Kanaan, J.; Maciej, V. D.; Fiorini, F.; Raj, S.; Croquette, V.; Le Hir, H.; Chakrabarti, S.: A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner. Nucleic Acids Research (London) 46 (5), pp. 2648 - 2659 (2018)

Falk, S.; Bonneau, F.; Ebert, J.; Kögel, A.; Conti, E.: Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase. Cell Reports 20 (10), pp. 2279 - 2286 (2017)

Leonaite, B.; Han, Z.; Basquin, J.; Bonneau, F.; Libri, D.; Porrua, O.; Conti, E.: Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family. EMBO Journal 36 (11), pp. 1590 - 1604 (2017)

Nakel, K.; Bonneau, F.; Basquin, C.; Habermann, B.; Eckmann, C. R.; Conti, E.: Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity. RNA 22 (8), pp. 1139 - 1145 (2016)

Nakel, K.; Bonneau, F.; Eckmann, C. R.; Conti, E.: Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112 (28), pp. 8614 - 8619 (2015)

Prabu, J. R.; Müller, M.; Thomae, A. W.; Schüssler, S.; Bonneau, F.; Becker, P. B.; Conti, E.: Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling. MOLECULAR CELL 60 (3), pp. 487 - 499 (2015)

Schäfer, I. B.; Rode, M.; Bonneau, F.; Schüssler, S.; Conti, E.: The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase. NATURE STRUCTURAL & MOLECULAR BIOLOGY 21 (7), pp. 591 - 598 (2014)

Benda, C.; Ebert, J.; Scheltema, R. A.; Schiller, H. B.; Baumgärtner, M.; Bonneau, F.; Mann, M.; Conti, E.: Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4. MOLECULAR CELL 56 (1), pp. 43 - 54 (2014)

Chakrabarti, S.; Bonneau, F.; Schüssler, S.; Eppinger, E.; Conti, E.: Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6. NUCLEIC ACIDS RESEARCH 42 (14), pp. 9447 - 9460 (2014)

Falk, S.; Weir, J. R.; Hentschel, J.; Reichelt, P.; Bonneau, F.; Conti, E.: The Molecular Architecture of the TRAMP Complex Reveals the Organization and Interplay of Its Two Catalytic Activities. MOLECULAR CELL 55 (6), pp. 856 - 867 (2014)

Mathys, H.; Basquin, J.; Ozgur, S.; Czarnocki-Cieciura, M.; Bonneau, F.; Aartse, A.; Dziembowski, A.; Nowotny, M.; Conti, E.; Filipowicz, W.: Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression. MOLECULAR CELL 54 (5), pp. 751 - 765 (2014)