Publications of Elena Conti

Mauxion, F.; Basquin, J.; Ozgur, S.; Rame, M.; Albrecht, J.; Schäfer, I.; Séraphin, B.; Conti, E.: The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions. Cell Reports, 111902 (2022)

Brüggenthies, J. B.; Fiore, A.; Russier, M.; Bitsina, C.; Brötzmann, J.; Kordes, S.; Menninger, S.; Wolf, A.; Conti, E.; Eickhoff, J. E. et al.; Murray, P. J.: A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling. Journal of Biological Chemistry 298 (12), 102629 (2022)

Gerlach, P.; Garland, W.; Lingaraju, M.; Salerno-Kochan, A.; Bonneau, F.; Basquin, J.; Jensen, T. H.; Conti, E.: Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Molecular Cell 82 (13), pp. 2505 - 2518 (2022)

Schmidt, M.; Kluge, F.; Sandmeir, F.; Kühn, U.; Schäfer, P.; Tüting, C.; Ihling, C.; Conti, E.; Wahle, E.: Reconstitution of 3′ end processing of mammalian pre-mRNA reveals a central role of RBBP6. Genes and Development 36, pp. 195 - 209 (2022)

Kögel, A.; Keidel, A.; Bonneau, F.; Schäfer, I. B.; Conti, E.: The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism. Molecular Cell 82 (4), pp. 756 - 769 (2022)

Langer, L. M.; Bonneau, F.; Gat, Y.; Conti, E.: Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8. eLife 10, e72353 (2021)

Busetto, V.; Barbosa, I.; Basquin, J.; Marquenet, E.; Hocq, R.; Hennion, M.; Paternina, J. A.; Namane, A.; Conti, E.; Bensaude, O. et al.; Le Hir, H.: Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes. Nucleic Acids Research (London) 48 (10), pp. 5670 - 5683 (2020)

Langer, L. M.; Gat, Y.; Bonneau, F.; Conti, E.: Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity. ELIFE 9, e57127 (2020)

Schuller, S. K.; Schuller, J. M.; Prabu, J. R.; Baumgärtner, M.; Bonneau, F.; Basquin, J.; Conti, E.: Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex. eLife 9, e61467 (2020)

Gat, Y.; Schuller, J. M.; Lingaraju, M.; Weyher, E.; Bonneau, F.; Strauss, M.; Murray, P. J.; Conti, E.: InsP(6) binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complex. Nature Structural and Molecular Biology 26 (12), pp. 1089 - 1093 (2019)

Lingaraju, M.; Johnsen, D.; Schlundt, A.; Langer, L. M.; Basquin, J.; Sattler, M.; Jensen, T. H.; Falk, S.; Conti, E.: The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs. Nature Communications 10, 3393 (2019)

Lingaraju, M.; Schuller, J. M.; Falk, S.; Gerlach, P.; Bonneau, F.; Basquin, J.; Benda, C.; Conti, E.: To Process or to Decay: A Mechanistic View of the Nuclear RNA Exosome. Cold Spring Harbor Symposia on Quantitative Biology 84, pp. 155 - 163 (2019)

Schäfer, I. B.; Yamashita, M.; Schuller, J. M.; Schüssler, S.; Reichelt, P.; Strauss, M.; Conti, E.: Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase. Cell 177 (6), pp. 1619 - 1631.e21 (2019)

Gerlach, P.; Schuller, J. M.; Bonneau, F.; Basquin, J.; Reichelt, P.; Falk, S.; Conti, E.: Distinct and evolutionary conserved structural features of the human nuclear exosome complex. eLife 7, e38686 (2018)

Conti, E.; Filipowicz, W.: Elisa Izaurralde (1959-2018). RNA 24 (8), pp. IX - X (2018)

Schuller, J. M.; Falk, S.; Fromm, L.; Hurt, E.; Conti, E.: Structure of the nuclear exosome captured on a maturing preribosome. Science 360 (6385), pp. 219 - 222 (2018)

Fromm, L.; Falk, S.; Flemming, D.; Schuller, J. M.; Thoms, M.; Conti, E.; Hurt, E.: Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome. Nature Communications 8, 1787 (2017)

Falk, S.; Bonneau, F.; Ebert, J.; Kögel, A.; Conti, E.: Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase. Cell Reports 20 (10), pp. 2279 - 2286 (2017)

Falk, S.; Tants, J.-N.; Basquin, J.; Thoms, M.; Hurt, E.; Sattler, M.; Conti, E.: Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53. RNA 23 (12), pp. 1780 - 1787 (2017)

Leonaite, B.; Han, Z.; Basquin, J.; Bonneau, F.; Libri, D.; Porrua, O.; Conti, E.: Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family. EMBO Journal 36 (11), pp. 1590 - 1604 (2017)