Publications of Robert Huber

Bolgi, O.; Silva-Garcia, M.; Ross, B.; Pilla, E.; Kari, V.; Killisch, M.; Spitzner, M.; Stark, N.; Lenz, C.; Weiss, K. et al.; Donzelli, L.; Gorrell, M. D.; Grade, M.; Riemer, J.; Urlaub, H.; Dobbelstein, M.; Huber, R.; Geiss-Friedlander, R.: Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair. EMBO Reports, e54136 (2022)

Lee, J.-H.; Bollschweiler, D.; Schäfer, T.; Huber, R.: Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Science Advances 7 (2), eabd4413 (2021)

Klatt, F.; Leitner, A.; Kim, I. V.; Ho-Xuan, H.; Schneider, E. V.; Langhammer, F.; Weinmann, R.; Mueller, M. R.; Huber, R.; Meister, G. et al.; Kuhn, C.-D.: A precisely positioned MED12 activation helix stimulates CDK8 kinase activity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117 (6), pp. 2894 - 2905 (2020)

Merdanovic, M.; Burston, S. G.; Schmitz, A. L.; Koecher, S.; Knapp, S.; Clausen, T.; Kaiser, M.; Huber, R.; Ehrmann, M.: Activation by substoichiometric inhibition. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117 (3), pp. 1414 - 1418 (2020)

Garcia-Guerrero, M. C.; Garcia-Pardo, J.; Berenguer, E.; Fernandez-Alvarez, R.; Barfi, G. B.; Lyons, P. J.; Aviles, F. X.; Huber, R.; Lorenzo, J.; Reverter, D.: Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues. Proceedings of the National Academy of Sciences of the United States of America 115 (17), pp. E3932 - E3939 (2018)

Ross, B.; Krapp, S.; Augustin, M.; Kierfersauer, R.; Arciniega, M.; Geiss-Friedlander, R.; Huber, R.: Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proceedings of the National Academy of Sciences of the United States of America 115 (7), pp. E1437 - E1445 (2018)

Dahms, S. O.; Arciniega, M.; Steinmetzer, T.; Huber, R.; Than, M. E.: Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism. Proceedings of the National Academy of Sciences of the United States of America 113 (40), pp. 11196 - 11201 (2016)

Hierold, J.; Baek, S.; Rieger, R.; Lim, T.-G.; Zakpur, S.; Arciniega, M.; Lee, K. W.; Huber, R.; Tietze, L. F.: Design, Synthesis, and Biological Evaluation of Quercetagetin Analogues as JNK1 Inhibitors. CHEMISTRY-A EUROPEAN JOURNAL 21 (47), pp. 16887 - 16894 (2015)

Park, G.; Baek, S.; Kim, J.-E.; Lim, T.-g.; Lee, C. C.; Yang, H.; Kang, Y.-G.; Park, J. S.; Augustin, M.; Mrosek, M. et al.; Lee, C. Y.; Dong, Z.; Huber, R.; Lee, K. W.: Flt3 is a target of coumestrol in protecting against UVB-induced skin photoaging. BIOCHEMICAL PHARMACOLOGY 98 (3), pp. 473 - 483 (2015)

Beaufort, N.; Scharrer, E.; Kremmer, E.; Lux, V.; Ehrmann, M.; Huber, R.; Houlden, H.; Werring, D.; Haffner, C.; Dichgans, M.: Cerebral small vessel disease-related protease HtrA1 processes latent TGF-beta binding protein 1 and facilitates TGF-beta signaling. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111 (46), pp. 16496 - 16501 (2014)

Kiefersauer, R.; Grandl, B.; Krapp, S.; Huber, R.: IR laser-induced protein crystal transformation. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70, pp. 1224 - 1232 (2014)

Lesca, E.; Lammens, A.; Huber, R.; Augustin, M.: Structural Analysis of the Human Fibroblast Growth Factor Receptor 4 Kinase. JOURNAL OF MOLECULAR BIOLOGY 426 (22), pp. 3744 - 3756 (2014)

Baek, S.; Kang, N. J.; Popowicz, G. M.; Arciniega Castro, M.; Jung, S. K.; Byun, S.; Song, N. R.; Heo, Y.-S.; Kim, B. Y.; Lee, H. J. et al.; Holak, T. A.; Augustin, M.; Bode, A. M.; Huber, R.; Dong, Z.; Lee, K. W.: Structural and Functional Analysis of the Natural JNK1 Inhibitor Quercetagetin. JOURNAL OF MOLECULAR BIOLOGY 425 (2), pp. 411 - 423 (2013)

Huber, R.: "How I Chose Research on Proteases or, More Correctly, How it Chose Me". ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52 (1), pp. 68 - 73 (2013)

Schneider, E. V.; Boettcher, J.; Huber, R.; Maskos, K.; Neumann, L.: Structure-kinetic relationship study of CDK8/CycC specific compounds. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110 (20), pp. 8081 - 8086 (2013)

Tennstaedt, A.; Popsel, S.; Truebestein, L.; Hauske, P.; Brockmann, A.; Schmidt, N.; Irle, I.; Sacca, B.; Niemeyer, C. M.; Brandt, R. et al.; Ksiezak-Reding, H.; Tirniceriu, A. L.; Egensperger, R.; Baldi, A.; Dehmelt, L.; Kaiser, M.; Huber, R.; Clausen, T.; Ehrmann, M.: Human High Temperature Requirement Serine Protease A1 (HTRA1) Degrades Tau Protein Aggregates. Journal of Biological Chemistry 287 (25), pp. 20931 - 20941 (2012)

Weski, J.; Meltzer, M.; Spaan, L.; Monig, T.; Oeljeklaus, J.; Hauske, P.; Vouilleme, L.; Volkmer, R.; Boisguerin, P.; Boyd, D. et al.; Huber, R.; Kaiser, M.; Ehrmann, M.: Chemical Biology Approaches Reveal Conserved Features of a C-Terminal Processing PDZ Protease. ChemBioChem 13 (3), pp. 402 - 408 (2012)

Baek, S.; Kutchukian, P. S.; Verdine, G. L.; Huber, R.; Holak, T. A.; Lee, K. W.; Popowicz, G. M.: Structure of the Stapled p53 Peptide Bound to Mdm2. Journal of the American Chemical Society 134 (1), pp. 103 - 106 (2012)

Gallastegui, N.; Beck, P.; Arciniega, M.; Huber, R.; Hillebrand, S.; Groll, M.: Hydroxyureas as Noncovalent Proteasome Inhibitors. Angewandte Chemie-International Edition 51 (1), pp. 247 - 249 (2012)

Stubbs, M. T.; Baumann, U.: No end in sight: the development of protein crystallography in Martinsried [Guest Editorial]. Biological Chemistry Hoppe-Seyler (Berlin) 393 (Special Issue), pp. 1025 - 1200 (2012)