Publications of R. Huber

Schneider, E. V.; Bottcher, J.; Blaesse, M.; Neumann, L.; Huber, R.; Maskos, K.: The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder. Journal of Molecular Biology 412 (2), pp. 251 - 266 (2011)

Clausen, T.; Kaiser, M.; Huber, R.; Ehrmann, M.: HTRA proteases: regulated proteolysis in protein quality control. Nature Reviews Molecular Cell Biology 12 (3), pp. 152 - 162 (2011)

Gräwert, M. A.; Gallastegui, N.; Stein, M.; Schmidt, B.; Kloetzel, P. M.; Huber, R.; Groll, M.: Elucidation of the alpha-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition. Angewandte Chemie-International Edition 50 (2), pp. 542 - 544 (2011)

Merdanovic, M.; Clausen, T.; Kaiser, M.; Huber, R.; Ehrmann, M.: Protein Quality Control in the Bacterial Periplasm. Annual Review of Microbiology 65, pp. 149 - 168 (2011)

Groll, M.; Gallastegui, N.; Marechal, X.; Le Ravalec, V.; Basse, N.; Richy, N.; Genin, E.; Huber, R.; Moroder, L.; Vidal, J. et al.; Reboud-Ravaux, M.: 20S Proteasome Inhibition: Designing Noncovalent Linear Peptide Mimics of the Natural Product TMC-95A. ChemMedChem 5 (10), pp. 1701 - 1705 (2010)

Clerc, J.; Schellenberg, B.; Groll, M.; Bachmann, A. S.; Huber, R.; Dudler, R.; Kaiser, M.: Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors. European Journal of Organic Chemistry (21), pp. 3991 - 4003 (2010)

Krojer, T.; Sawa, J.; Huber, R.; Clausen, T.: HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues. Nature Structural & Molecular Biology 17 (7), pp. 844 - 852 (2010)

Merdanovic, M.; Mamant, N.; Meltzer, M.; Poepsel, S.; Auckenthaler, A.; Melgaard, R.; Hauske, P.; Nagel-Steger, L.; Clarke, A. R.; Kaiser, M. et al.; Huber, R.; Ehrmann, M.: Determinants of structural and functional plasticity of a widely conserved protease chaperone complex. Nature Structural & Molecular Biology 17 (7), pp. 837 - 843 (2010)

Ducka, A. M.; Joel, P.; Popowicz, G. M.; Trybus, K. M.; Schleicher, M.; Noegel, A. A.; Huber, R.; Holak, T. A.; Sitar, T.: Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proceedings of the National Academy of Sciences of the United States of America 107 (26), pp. 11757 - 11762 (2010)

Hasenbein, S.; Meltzer, M.; Hauske, P.; Kaiser, M.; Huber, R.; Clausen, T.; Ehrmann, M.: Conversion of a Regulatory into a Degradative Protease. Journal of Molecular Biology 397 (4), pp. 957 - 966 (2010)

Groll, M.; Gallastegui, N.; Maréchal, X.; Le Ravalec, V.; Basse, N.; Richy, N.; Genin, E.; Huber, R.; Moroder, L.; Vidal, J. et al.; Reboud-Ravaux, M.: 20S Proteasome Inhibition: Designing Noncovalent Linear Peptide Mimics of the Natural Product TMC-95A. ChemMedChem 5, pp. 1701 - 1705 (2010)

Huber, R.: Nobelpreisträger im Gespräch: Ich bin ins Innere der Moleküle gestiegen. Kontaktum Magazin 2, pp. 6 - 11 (2010)

Clerc, J.; Florea, B. I.; Kraus, M.; Groll, M.; Huber, R.; Bachmann, A. S.; Dudler, R.; Driessen, C.; Overkleeft, H. S.; Kaiser, M.: Syringolin A Selectively Labels the 20 S Proteasome in Murine EL4 and Wild-Type and Bortezomib-Adapted Leukaemic Cell Lines. ChemBioChem 10 (16), pp. 2638 - 2643 (2009)

Meltzer, M.; Hasenbein, S.; Mamant, N.; Merdanovic, M.; Poepsel, S.; Hauske, P.; Kaiser, M.; Huber, R.; Krojer, T.; Clausen, T. et al.; Ehrmann, M.: Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli. Research in Microbiology 160 (9 Sp. Iss.), pp. 660 - 666 (2009)

Breithaupt, C.; Kurzbauer, R.; Schaller, F.; Stintzi, A.; Schaller, A.; Huber, R.; Macheroux, P.; Clausen, T.: Structural Basis of Substrate Specificity of Plant 12-Oxophytodienoate Reductases. Journal of Molecular Biology 392 (5), pp. 1266 - 1277 (2009)

Ottmann, C.; Rose, R.; Huttenlocher, F.; Cedzich, A.; Hauske, P.; Kaiser, M.; Huber, R.; Schaller, A.: Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3. Proceedings of the National Academy of Sciences of the United States of America 106 (40), pp. 17223 - 17228 (2009)

Lee, J. H.; Maskos, K.; Huber, R.: Structural and Functional Studies of the Yeast Class II Hda1 Histone Deacetylase Complex. Journal of Molecular Biology 391 (4), pp. 744 - 757 (2009)

Tochowicz, A.; Maskos, K.; Huber, R.; Oltenfreiter, R.; Dive, V.; Yiotakis, A.; Zanda, M.; Pourmotabbed, T.; Bode, W.; Goettig, P.: Corrigendum to "Crystal Structures of MMP-9 Complexes with Five Inhibitors: Contribution of the Flexible Arg424 Side Chain to Selectivity" (Journal of Molecular Biology, vol 371, pg 989, 2007). Journal of Molecular Biology 388 (4), pp. 917 - 918 (2009)

Wolschner, C.; Giese, A.; Kretzschmar, H. A.; Huber, R.; Moroder, L.; Budisa, N.: Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein. Proceedings of the National Academy of Sciences of the United States of America 106 (19), pp. 7756 - 7761 (2009)

Clerc, J.; Groll, M.; Illich, D. J.; Bachmann, A. S.; Huber, R.; Schellenberg, B.; Dudler, R.; Kaiser, M.: Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition. Proceedings of the National Academy of Sciences of the United States of America 106 (16), pp. 6507 - 6512 (2009)