Publications of Brenda A. Schulman

Horn-Ghetko, D.; Hopf, L. V.M.; Tripathi-Giesgen, I.; Du, J.; Kostrhon, S.; Tung Vu, D.; Beier, V.; Steigenberger, B.; Prabu, J. R.; Stier, L. et al.; Bruss, E. M.; Mann, M.; Xiong, Y.; Schulman, B. A.: Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex. Nature Structural & Molecular Biology (2024)

Liwocha, J.; Li, J.; Purser, N.; Rattanasopa, C.; Maiwald, S.; Krist, D. T.; Scott, D. C.; Steigenberger, B.; Prabu, J. R.; Schulman, B. A. et al.; Kleiger, G.: Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases. Nature Structural & Molecular Biology 31, pp. 378 - 389 (2024)

Chrustowicz, J.; Sherpa, D.; Li, J.; Langlois, C. R.; Papadopoulou, E. C.; Tung Vu, D.; Hehl, L. A.; Karayel, Ö.; Beier, V.; Gronau, S. v. et al.; Müller, J.; Prabu, J. R.; Mann, M.; Kleiger, G.; Alpi, A. F.; Schulman, B. A.: Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies. Molecular Cell 84 (2), pp. 293 - 308 (2024)

Botsch, J. J.; Junker, R.; Sorgenfrei, M.; Ogger, P. P.; Stier, L.; von Gronau, S.; Murray, P. J.; Seeger, M. A.; Schulman, B. A.; Bräuning, B.: Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE. Nature Communications 15 (1), 410 (2024)

Gross, A.; Müller, J.; Chrustowicz, J.; Strasser, A.; Gottemukkala, K. V.; Sherpa, D.; Schulman, B. A.; Murray, P. J.; Alpi, A. F.: Skraban-Deardorff intellectual disability syndrome-associated mutations in WDR26 impair CTLH E3 complex assembly. FEBS Letters (2024)

Hoyer, M. J.; Capitanio, C.; Smith, I. R.; Paoli, J. C.; Bieber, A.; Jiang, Y.; Paulo, J. A.; Gonzalez-Lozano, M. A.; Baumeister, W.; Wilfling, F. et al.; Schulman, B. A.; Harper, J. W.: Combinatorial selective ER-phagy remodels the ER during neurogenesis. Nature Cell Biology 26, pp. 378 - 392 (2024)

Wallace, I.; Baek, K.; Prabu, J. R.; Vollrath, R.; von Gronau, S.; Schulman, B. A.; Swatek, K. N.: Insights into the ISG15 transfer cascade by the UBE1L activating enzyme. Nature Communications 14 (1), 7970 (2023)

Purser, N.; Tripathi-Giesgen, I.; Li, J.; Scott, D. C.; Horn-Ghetko, D.; Baek, K.; Schulman, B. A.; Alpi, A. F.; Kleiger, G.: Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase. Biochemical Journal 480 (22), pp. 1817 - 1831 (2023)

Henneberg, L. T.; Singh, J.; Duda, D. M.; Baek, K.; Yanishevski, D.; Murray, P. J.; Mann, M.; Sidhu, S. S.; Schulman, B. A.: Activity-based profiling of cullin-RING E3 networks by conformation-specific probes. Nature Chemical Biology (2023)

Hehl, L. A.; Horn-Ghetko, D.; Prabu, J. R.; Vollrath, R.; Tung Vu, D.; Pérez Berrocal, D. A.; Mulder, M. P. C.; van der Heden van Noort, G. J.; Schulman, B. A.: Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5. Nature Chemical Biology (2023)

Hehl, L. A.; Schulman, B. A.: To be (in a transcriptional complex) or not to be (promoting UBR5 ubiquitylation): That is an answer to how degradation controls gene expression. Molecular Cell 83 (15), pp. 2616 - 2618 (2023)

Berrocal, D. A. P. A.; Vishwanatha, T. M.; Horn-Ghetko, D.; Botsch, J. J.; Hehl, L. A.; Kostrhon, S.; Misra, M.; Dikic, I.; Geurink, P. P.; van Dam, H. et al.; Schulman, B. A.; Mulder, M. P. C.: A Pro-Fluorescent Ubiquitin-Based Probe to Monitor Cysteine-Based E3 Ligase Activity. Angewandte Chemie International Edition 62 (32), e202303319 (2023)

Baek, K.; Scott, D. C.; Henneberg, L. T.; King, M. T.; Mann, M.; Schulman, B. A.: Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell 186 (9), pp. 1895 - 1911 (2023)

Scott, D. C.; King, M. T.; Baek, K.; Gee, C. T.; Kalathur, R.; Li, J.; Purser, N.; Nourse, A.; Chai, S. C.; Vaithiyalingam, S. et al.; Chen, T.; Lee, R. E.; Elledge, S. J.; Kleiger, G.; Schulman, B. A.: E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity. Molecular Cell 83 (5), pp. 770 - 786 (2023)

Li, M.; Tripathi-Giesgen, I.; Schulman, B. A.; Baumeister, W.; Wilfling, F.: In situ snapshots along a mammalian selective autophagy pathway. Proceedings of the National Academy of Sciences of the United States of America 120 (12), e2221712120 (2023)

Nardone, C.; Palanski, B. A.; Scott, D. C.; Timms, R. T.; Barber, K. W.; Gu, X.; Mao, A.; Leng, Y.; Watson, E. V.; Schulman, B. A. et al.; Cole, P. A.; Elledge, S. J.: A central role for regulated protein stability in the control of TFE3 and MITF by nutrients. Molecular Cell 83 (1), pp. 57 - 73 (2023)

Gonzalez, A.; Covarrubias-Pinto, A.; Bhaskara, R. M.; Glogger, M.; Kuncha, S. K.; Xavier, A.; Seemann, E.; Misra, M.; Hoffmann, M. E.; Bräuning, B. et al.; Balakrishnan, A.; Qualmann, B.; Doetsch, V.; Schulman, B. A.; Kessels, M. M.; Huebner, C. A.; Heilemann, M.; Hummer, G.; Dikic, I.: Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum. Nature, pp. 394 - 401 (2023)

Kraus, F.; Goodall, E. A.; Smith, I. R.; Jiang, Y.; Paoli, J. C.; Adolf, F.; Zhang, J.; Paulo, J. A.; Schulman, B. A.; Harper, J. W.: PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems. EMBO Reports, e56399 (2023)

Sherpa, D.; Mueller, J.; Karayel, Ö.; Xu, P.; Yao, Y.; Chrustowicz, J.; Gottemukkala, K. V.; Baumann, C.; Gross, A.; Czarnecki, O. et al.; Zhang, W.; Gu, J.; Nilvebrant, J.; Sidhu, S. S.; Murray, P. J.; Mann, M.; Weiss, M. J.; Schulman, B. A.; Alpi, A. F.: Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation. eLife 11, e77937 (2022)

Dikic, I.; Schulman, B. A.: An expanded lexicon for the ubiquitin code. Nature Reviews Molecular Cell Biology (2022)