Publications

Selected primary research papers from the lab:

Chacin E, Bansal P, Reusswig KU, Diaz-Santin LM, Ortega P, Vizjak P, Gomez-Gonzales B, Müller-Planitz F, Aguilera A, Pfander B, Cheung ACM, Kurat CF* (2021). A CDK-regulated chromatin segregase involved in chromosome replication. Nature Commun.12, doi: 10.1038/s41467-021-25424-7

Peritore M, Reusswig KU, Bantele S, Straub T, Pfander B*. (2021). Strand-specific ChIP-seq at DNA breaks distinguishes single versus double-stranded DNA binding and refutes single-stranded nucleosomes. Mol Cell. 81(1), 1-13 doi: 10.1016/j.molcel.2021.02.005

Ferreira P, Höfer V, Kronshage N, Marko A, Reusswig KU, Tetik B, Köhler K, Tschernoster N, Altmüller J, Schulze N, Pfander B, Boos D*. (2021). MTBP phosphroylation controls DNA replication origin firing. Sci Rep. 11(1), 1-14 doi:10.1038/s41598-021-83287

Bittmann J, Grigaitis R, Galanti L, Amarell S, Wilfling F, Matos J & Pfander B*. (2020). An advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases. Elife. May 1;9:e52459. doi: 10.7554/eLife.52459.

Bantele SCS, Lisby M & Pfander B*. (2019). Quantitative sensing of ssDNA accumulation by DNA damage checkpoint mediators. Nature Commun. 10., doi: 10.1038/s41467-019-08889-5

di Cicco G, Bantele SCS, Reusswig KU & Pfander B*. (2017). A cell cycle-independent mode of the Rad9-Dpb11 interaction is induced by DNA damage. Sci Rep. doi: 10.1038/s41598-017-11937-z.

Princz LN, Wild P, Bittmann J, Aguado FJ, Blanco MG, Matos J & Pfander B*. (2017). Dbf4-dependent kinase and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosis. EMBO J. doi: 10.15252/embj.201694831.

Bantele SCS, Ferreira P, Gritenaite D, Boos D & Pfander B*. (2017).Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection. Elife. pii: e21687. doi: 10.7554/eLife.21687.

Reusswig KU, Zimmermann F, Galanti L & Pfander B*. (2016). Robust Replication Control Is Generated by Temporal Gaps between Licensing and Firing Phases and Depends on Degradation of Firing Factor Sld2. Cell Rep. 17(2):556-569. doi: 10.1016/j.celrep.2016.09.013.

Lee SH, Princz LN, Klügel MF, Habermann B, Pfander B & Biertümpfel C*. (2015). Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage. Elife. pii:e12256. doi: 10.7554/eLife.12256.

Gritenaite D, Princz LN, Szakal B, Bantele SCS, Wendeler L, Schilbach S, Habermann BH, Matos J, Lisby M, Branzei D, Pfander B*. (2014). A cell cycle-regulated Slx4-Dpb11 signaling complex controls the resolution of DNA repair intermediates linked to stalled replication. Genes Dev. 28(14):1604-1619. doi: 10.1101/gad.240515.114.

Reviews and book chapters from the lab:

Karl LA, Peritore M, Galanti L, Pfander B* (2022). DNA Double Strand Break Repair and Its Control by Nucleosome Remodeling. Front Genet. doi: 10.3389/fgene.2021.821543. eCollection 2021.

Bantele SC & Pfander B* (2019). Nucleosome remodeling by Fun30/SMARCAD1 in the DNA damage response. Front Mol Biosci. doi: 10.3389/fmolb.2019.00078

Bantele SC & Pfander B* (2019). Quantitative mechanisms of DNA damage sensing and signaling. Curr Genet. doi: 10.1007/s00294-019-01007-4.

Reusswig KU & Pfander B. (2019). Control of DNA replication initiation – mechanisms to ensure smooth transitions. Genes. 10(2) doi: 10.3390/genes10020099.

Galanti L & Pfander B*. (2018). Right time, right place-DNA damage and DNA replication checkpoints collectively safeguard S phase. EMBO J. 37(21). pii: e100681. doi: 10.15252/embj.2018100681

Reusswig KU, Boos D & Pfander B. (2016). Roles of Sld2, Sld3, and Dpb11 in Replication Initiation. in: The initiation of DNA replication in eukaryotes. pp 297-318. Springer. doi: 10.1007/978-3-319-24696-3.

Koehler K, Ferreira P, Pfander B & Boos, D. (2016). Regulation of the Initiation of DNA Replication upon DNA Damage in Eukaryotes. in: The initiation of DNA replication in eukaryotes. pp 443-460. Springer. doi: 10.1007/978-3-319-24696-3.

Princz LN, Gritenaite D & Pfander B. (2014). The Slx4-Dpb11 scaffold complex: coordinating the response to replication fork stalling in S-phase and the subsequent mitosis. Cell Cycle. 14(4):488-494. doi: 10.4161/15384101.2014.989126.

Further primary research papers from Boris:

Capella M, Mandemaker IK, , Caballero LM, den Brave F, Pfander B, Ladurner AG, Jentsch S, Braun S* (2021). Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase.
Nature Commun. 12, doi: 10.1038/s41467-021-25205-2

Allegretti M, Zimmerli C, Rantos V, Wilfling F, Ronchi P, Fung KHH, Lee C, Hagen W, Turonova B, , Karius K, Bömmel M, Zhang X, Müller CW, Schwab Y, Mahamid J, Pfander B*, Kosinski J*, Beck M* (2020) In cell architecture of the nuclear pore and snapshots of its turnover. Nature, doi: 10.1038/s41586-020-2670-5 Epub 2020 Sep 2

Lee CW, Wilfling F, Ronchi P, Allegretti M, Mosalaganti S, Jentsch S, Beck M* & Pfander B*. (2020). Selective autophagy degrades nuclear pore complexes. Nat Cell Biol. Feb;22(2):159-166. doi: 10.1038/s41556-019-0459-2. Epub 2020 Feb 6

Capella M, Caballero LM, Pfander B, Braun S*, Jentsch S. (2020) ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing.
J Cell Sci, 133 (24), doi: 10.1242/jcs.250688

Heckmann I, Kern MJ, Pfander B*, Jentsch S. (2019) A SUMO-dependent pathway controls elongating Rpb1 upon UV-induced damage Scientific Reports. 9(1), 1-10

Höpfler M, Kern MJ, Straub T, Prytuliak R, Habermann BH, Pfander B*, Jentsch S. (2019). Specificity in the STUbL-pathway exemplified by recruitment of Slx5/Slx8 to ubiquitin hotspots on chromatin. EMBO J. 10.15252/embj.2018100368

Paasch F, den Brave F, Psakhye I, Pfander B*, Jentsch S (2018). Failed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins. J Biol Chem. 293 (2); 599-609. doi: 10.1074/jbc.M117.817833.

Karaduman R*, Chanarat S*, Pfander B*, Jentsch S (2017). Error-Prone Splicing Controlled by the Ubiquitin Relative Hub1. Mol Cell. 67(3); 423-432. doi: 10.1016/j.molcel.2017.06.021.

Lademann, C.A., Renkawitz, J., Pfander, B.* & Jentsch, S. (2017). The INO80 Complex Removes H2A.Z to Promote Presynaptic Filament Formation during Homologous Recombination. Cell Reports. 19(7):1294-1303. doi: 10.1016/j.celrep.2017.04.051.

Pfander B & Diffley, JFX (2011). Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment. EMBO J. 30: 4897-4907

Parnas O, Zipin-Roitman A, Pfander B, Liefshitz B, Mazor Y, Ben-Aroya S, Jentsch S & Kupiec M. (2010). Elg1, an alternative subunit of the RF-C clamp loader, preferentially interacts with SUMOylated PCNA. EMBO J. 29:2611-2622

Sacher M, Pfander B, Hoege C & Jentsch S. (2006). Control of Rad52 recombination activity by double-strand break-induced SUMO modification. Nature Cell Biology. 8, 1284-1290

Moldovan GL, Pfander B & Jentsch S. (2006). PCNA controls establishment of sister chromatid cohesion during S-phase. Molecular Cell. 23, 723-732

Döring M, Loos A, Schrader N, Pfander B & Bauerfeind R. (2006). Nerve growth factor-induced phosphorylation of amphiphysin-1 by casein kinase 2 regulates clathrin-amphiphysin interactions. Journal of Neurochemistry. 98, 2013-2023

Pfander B, Moldovan GL, Sacher M, Hoege C & Jentsch S. (2005). SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase. Nature. 436, 428-433

Hoege C, Pfander B, Moldovan GL, Pyrowolakis G & Jentsch S. (2002). RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature. 419, 135-141

Other reviews and book chapters from Boris:

Moldovan GL, Pfander B & Jentsch S. (2007). PCNA, the maestro of the replication fork. Cell. 129, 665-679

Sacher M#, Pfander B# & Jentsch S. (2005). Identification of SUMO-protein conjugates. Methods in Enzymology. 399, 392-404 (# equal contribution)