Research Group "DNA Replication & Genome Integrity"
DNA Replication, Checkpoints, DNA damage, Posttranslational Modifications, Yeast
In the process of DNA replication, all cells duplicate their DNA so that mother and daughter cells receive the same genetic information during cell division. DNA replication has to be very precise and requires a strict chronological order, as errors can cause changes in genetic information, leading to cancer or other serious diseases. Boris Pfander and his research group "DNA Replication and Genome Integrity" are investigating how to ensure the necessary precision and prevent errors. The scientists combine classical methods of yeast genetics with modern proteome- and genome-wide approaches. One focus of the research group is to find out how DNA replication takes place in the presence of DNA damage and how it is interlocked with DNA repair.