Chronic excessive caloric intake leads to the deposition of fat droplets in the liver. This condition, known as fatty liver, can cause permanent damage to the organ. Researchers at the Max Planck Institute of Biochemistry (MPIB) in Martinsried have now investigated the effects of this fat overflow on liver proteins. They showed that fatty liver is associated with changes in the location and activity of numerous cellular proteins. The study, which was published in the journal Developmental Cell, shows the effect of lipid deposition on fundamental cellular processes in the liver.