Research Group "Chromatin Biology"
Genetics and Biochemistry of Chromatin, Transcription, Histone Modifications, Drosophila Development
In the nucleus of plants and animals, genomic DNA is organized in the form of chromosomes. The basic building block of chromosomes is the nucleosome. Each nucleosome consists of a protein complex of histone proteins around which 147 base pairs of DNA are wrapped. The removal, incorporation and modification of histone proteins are important steps in almost all processes that take place on genomic DNA. Jürg Müller's research group "Chromatin Biology" is investigating how nucleosomes and post-translational modifications of histone proteins regulate gene transcription and genome integrity. A major goal of the group is to visualize at the molecular level how chromatin-modifying protein complexes recognize nucleosomes and their modifications.