Publications

2023

Ecke, M., Prassler, J., and Gerisch, G. : Expanding ring-shaped cleavage furrows in multi-nucleate cells. Molecular Biology of the Cell,  2023 34:4, https://doi.org/10.1091/mbc.E22-10-0487.

Ecke, M., Prassler, J., and Gerisch, G. : Fluctuations of formin binding in the generation of membrane patterns. Biophysical Journal, in press, https://doi.org/10.1016/j.bpj.2023.07.014

 

2022

Rußbach, L. , Ecke, M. , Rädler, J.O. , Charlott Leu, C. , Gerisch, G.: Cells responding to chemoattractant on a structured substrate. Biophysical Journal, https://doi.org/10.1016/j.bpj.2022.05.043.

Gerisch, G., Prassler, J., and Ecke, M.: Patterning of the cell cortex and the localization of cleavage furrows in multi-nucleate cells. Journal of Cell Science, jcs.259648; https://doi.org/10.1242/jcs.259648

2021

Ecke, M., Prassler, J., and Gerisch, G.: Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium. Cells 2021, 10(9), 2240; https://doi.org/10.3390/cells10092240

2020

Bindl, J., Molnar, E. S., Ecke, M., Prassler, J., Müller-Taubenberger, A., and Gerisch, G.: Unilateral cleavage furrows in multinucleate cells. Cells 2020, 9(6), 1493; https://doi.org/10.3390/cells9061493

Ecke, M., Prassler, J., Tanribil, P., Müller-Taubenberger, A., Körber, S., Faix, J., and Gerisch, G.: Formins specify membrane patterns generated by propagating actin waves. Molecular Biology of the Cell, Published Online: 15 Jan 2020, https://doi.org/10.1091/mbc.E19-08-0460

Prassler, J., Simon, F., Ecke, M., Gruber, S. and Gerisch, G.: Decision Making in Phagocytosis: in The Molecular and Cellular Biology of Phagocytosis, Hallett, Maurice B. (Ed.), Advances in Experimental Medicine and Biology, 1246, 1, Springer International Publishing, Springer Nature, accepted, date of publication: 27 Jun 2020

2019

Gerisch, G., Prassler, J., Butterfield, N., Ecke, M.: Actin waves and dynamic patterning of the plasma membrane. Yale Journal of Biology and Medcine, in press

Jasnin M., Beck F., Ecke M., Fukuda Y., Martinez-Sanchez A., Baumeister W., and Gerisch G.: The Architecture of Traveling Actin Waves Revealed by Cyro-electron Tomography, Structure (2019), doi: 10.1016/j.str.2019.05.009

2018

Helenius, J., Ecke, M., Müller, D. J. & Gerisch, G.: Oscillatory Switches of Dorso-Ventral Polarity in Cells Confined between Two Surfaces. Biophysical Journal 115, 150-162 (2018)

2017

Ecke M., Gerisch G.: Co-existence of Ras activation in a chemotactic signal transduction pathway and in an autonomous wave - forming system. Small GTPases:1-9 (2017)

2016

Gerisch G., Ecke M.: Wave Patterns in Cell Membrane and Actin Cortex Uncoupled from Chemotactic Signals. Methods Mol Biol. 1407:79-96 (2016)

Jasnin M., Ecke M., Baumeister W., Gerisch G.: Actin Organization in Cells Responding to a Perforated Surface, Revealed by Live Imaging and Cryo-Electron Tomography. Structure. 24 (7):1031-1043 (2016)

Lange M., Prassler J., Ecke M., Müller-Taubenberger A., Gerisch G.: Local Ras activation, PTEN pattern, and global actin flow in the chemotactic responses of oversized cells. J Cell Sci. 129 (18):3462-3472 (2016)

2014

Gerhardt M., Ecke M., Walz M., Stengl A., Beta C., and Gerisch G.: Actin and PIP3 waves in giant cells reveal the inherent length scale of an excited state. J. Cell Sci. (2014)

Heinrich, D., Ecke, M., Jasnin, M., Engel, U. & Gerisch, G. Reversible Membrane Pearling in Live Cells upon Destruction of the Actin Cortex. Biophys. J. 106, 1079-1091 (2014).

2013

Gerisch, G., Ecke, M., Neujahr, R., Prassler, J., Stengl, A., Hoffmann, M., Schwarz, U.S., Neumann, E. : Membrane and actin reorganization in electropulse-induced cell fusion. J. Cell Sci. 126 (9), 2096-2078 (2013)

2012

Gerisch, G., Schroth-Diez, B., Müller-Taubenberger, A., Ecke, M., : PIP3 Waves and PTEN Dynamics in the Emergence of Cell Polarity. Biophys. J. 103 (6), 1170-1178 (2012).

2011

Gerisch, G., Ecke, M., Wischnewski, D., and Schroth-Diez, B.: Different modes of state transitions determine pattern in the Phosphatidylinositide-Actin system. BMC Cell Biology 12: 42 (2011).

Gerisch, G.: Actin switches in phagocytosis. Communicative & Integrative Biology 4: 344-345 (2011).

2010

Clarke, M., Engel, U., Giorgione, J., Müller-Taubenberger, A., Prassler, J., Veltman, D., and Gerisch, G.: Curvature recognition and force generation in phagocytosis. BMC Biology 8:154 (2010).

Medalia, O., Beck, M., Ecke, M., Weber, I., Neujahr, R., Baumeister, W. and Gerisch, G.: Organization of actin networks in intact filopodia. Curr. Biol. 17, 79-84 (2007).

Gerisch, G.: Self-organizing actin waves that simulate phagocytic cup structures. PMC Biophysics 3:7 (2010).

Clarke, M., Maddera, L., Engel, U., and Gerisch, G.: Retrieval of the vacuolar H+-ATPase from phagosomes revealed by live cell imaging. PLoS One 5 :e8585:1-14 (2010).

2009

2008

Heinrich, D., Youssef, S., Schroth-Diez, B., Engel, U., Aydin, D., Blümmel, J., Spatz, J., and Gerisch, G.: Actin-cytoskeleton dynamics in non-monotonic cell spreading. Cell Adhesion & Migration 2, 58-68 (2008).

Dalous, J. Burghardt, E., Müller-Taubenberger, A., Bruckert, F., Gerisch, G.and Bretschneider, T.: Reversal of cell polarity and actin-myosin cytoskeleton reorganization under mechanical and chemical stimulation. Biophys. J. 94, 1063-1074 (2008).

2007

Gerisch,G. and Weber, I.: Toward the structure of dynamic membrane-anchored actin networks: An approach using cryo-electron tomography.Cell Adhesion & Migration 1, 145-148 (2007).

Medalia, O., Beck, M., Ecke, M., Weber, I., Neujahr, R., Baumeister, W. and Gerisch, G.: Organization of actin networks in intact filopodia. Curr. Biol. 17, 79-84 (2007).

2006

Schirenbeck, A., Arasada, R., Bretschneider T., Stradal, T.E., Schleicher, M. and Faix, J.: The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation. Proc. Natl. Acad. Sci. 103, 7694-7699 (2006).

Etzrodt, M., Ishikawa, H.C.F., Dalous, J., Müller-Taubenberger, A., Bretschneider, T. and Gerisch,G.: Time-resolved responses to chemoattractant, characteristic of the front and tail of Dictyostelium cells. FEBS Letters 580, 6707-6713 (2006).

Clarke, M., Müller-Taubenberger, A., Anderson, K.I., Engel, U. and Gerisch, G.: Mechanically induced actin-mediated rocketing of phagosomes. Mol. Biol. Cell 17, 4866-4875 (2006).

2005

Diez, S., Gerisch, G., Anderson, K., Müller-Taubenberger, A. and Bretschneider, T.: Subsecond reorganization of the actin network in cell motility and chemotaxis. Proc. Natl. Acad. Sci. 102, 7601-7606 (2005).

Gerisch, G. and Ecke, M.: Chemotaxis of aggregating Dictyostelium cells. In: Key Experiments in Practical Developmental Biology (Eds. M. Marí-Beffa and J. Knight), pp. 50-66. Cambridge University Press 2005.

Schirenbeck A., T. Bretschneider, R. Arasada, M. Schleicher, J. Faix. The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia. Nature Cell Biology, 7(6):619-625, 2005a.

Schirenbeck A., R. Arasada, T. Bretschneider, M. Schleicher, J. Faix. Formins and VASPs may co-operate in the formation of filopodia. Biochem. Soc. Trans., 33(6):1256-1259, 2005b

Weisswange I., T. Bretschneider, K. Anderson. The leading edge is a lipid diffusion barrier. J. of Cell Science, 118(19):4375-4380, 2005.

van der Horst, E., Weber, I., and Ullrich, A. Tyrosine phosphorylation of PYK2 mediates heregulin-induced glioma invasion: Novel heregulin/HER3-stimulated signaling pathway in glioma. International Journal of Cancer 113, 689-698.

2004

Beck, M., Förster, F., Ecke, M., Plitzko, J.M., Melchior, F., Gerisch, G., Baumeister, W., and Medalia, O. (2004). Nuclear pore complex structure and dynamics revealed by cryoelectron tomography.
Science 306, 1387-1390.

Bretschneider, T., Diez, S., Anderson, K., Heuser, J., Clarke, M., Müller-Taubenberger, A., Köhler, J., and Gerisch, G. (2004). Dynamic actin patterns and Arp2/3 assembly at the substrate-attached surface of motile cells. Current Biology 14, 1-10.

Bretschneider, T. (2004). Reinforcement of cytoskeleton-matrix bonds and tensiotaxis: a cell-based model.
In: Function and Regulation of Cellular Systems: Experiments and Models (Eds. Deutsch, A., Falcke, M., Howard, J., and Zimmermann, W.), pp. 279-286. Birkhäuser, Basel.

Fischer, M., Haase, I., Simmeth, E., Gerisch, G., and Müller-Taubenberger, A. (2004). A brilliant monomeric red fluorescent protein to visualize cytoskeleton dynamics in Dictyostelium. FEBS Letters 577, 227-232.

Gerisch, G., Benjak, A., Köhler, J., Weber, I., and Schneider, N. (2004). GFP-golvesin constructs to study Golgi tubulation and post-Golgi vesicle dynamics in phagocytosis. European Journal of Cell Biology 83, 297-303.

Gerisch, G., Bretschneider, T., Müller-Taubenberger, A., Simmeth, E., Ecke, M., Diez, S., and Anderson, K. (2004). Mobile actin clusters and traveling waves in cells recovering from actin depolymerization.
Biophysical Journal 87, 3493-3503.

Gerisch, G., Faix, J., Köhler, J., and Müller-Taubenberger, A. (2004). Actin-binding proteins required for reliable chromosome segregation in mitosis. Cell Motility and the Cytoskeleton 57, 18-25.

Müller-Taubenberger, A., and Maniak, M. (2004). Dictyostelium discoideum: Cellular slime mold.
In: Encyclopedia of Molecular Cell Biology and Molecular Medicine Vol. 3 (Ed. R.A. Meyers) , pp. 325-349.
Wiley-VCH.

2002

Albrecht, R., and Weber, I. (2002). Interference reflection microscopy. In: Encyclopedia of Life Sciences Vol. 10, pp. 369-371 (www.els.net). Nature Publishing Group, London.

Bretschneider, T., Jonkman, J., Köhler, J., Medalia, O., Barisic, K., Weber, I., Stelzer, E.H.K., Baumeister, W., and Gerisch, G. (2002). Dynamic organization of the actin system in the motile cells of Dictyostelium. Journal of Muscle Research and Cell Motility 23, 639-649.

Clarke, M., Köhler, J., Arana, Q., Liu, T., Heuser, J., and Gerisch, G. (2002). Dynamics of the vacuolar H+-ATPase in the contractile vacuole complex and the endosomal pathway of Dictyostelium cells. Journal of Cell Science 115, 2893-2905.

Clarke, M., Köhler, J., Heuser, J., and Gerisch, G. (2002). Endosome fusion and microtubule-based dynamics in the early endocytic pathway of Dictyostelium. Traffic 3, 791-800.

Dormann, D., Libotte, T., Weijer, C.J., and Bretschneider, T. (2002). Simultaneous quantification of cell motility and protein-membrane-association using active contours. Cell Motility and the Cytoskeleton 52, 221-230.

Gerisch, G., Heuser, J., and Clarke, M. (2002). Tubular-vesicular transformation in the contractile vacuole system of Dictyostelium. Cell Biology International 26, 845-852.

Medalia, O., Weber, I., Frangakis, A.S., Nicastro, D., Gerisch, G., and Baumeister, W. (2002). Macromolecular architecture in eukaryotic cells visualized by cryoelectron tomography. Science 298, 1209-1213.

Müller-Taubenberger, A., Bretschneider, T., Faix, J., Konzok, A., Simmeth, E., and Weber, I. (2002). Differential localization of the Dictyostelium kinase DPAKa during cytokinesis and cell migration. Journal of Muscle Research and Cell Motility 23, 751-763.

Weber, I., and Gerisch, G. (2002). Cortexillins. In: Wiley Encyclopedia of Molecular Medicine 5 Vol. Set, pp. 914-916.

Weber, I., Niewöhner, J., Du, A., Röhrig, U., and Gerisch, G. (2002). A talin fragment as an actin trap visualizing actin flow in chemotaxis, endocytosis, and cytokinesis. Cell Motility and the Cytoskeleton 53, 136-14

2001

Faix, J., Weber, I., Mintert, U., Köhler, J., Lottspeich, F., and Marriott, G. (2001). Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins. EMBO Journal 20, 3705-3715.

Feneberg, W., Westphal, M., and Sackmann, E. (2001). Dictyostelium cells' cytoplasm as active viscoplastic body. European Biophysics Journal 30, 284-294.

Insall, R., Müller-Taubenberger, A., Machesky, L., Köhler, J., Simmeth, E., Atkinson, S.J., Weber, I., and Gerisch, G. (2001). Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis. Cell Motility and the Cytoskeleton 50, 115-128.

Müller-Taubenberger, A., Lupas, A.N., Li, H., Ecke, M., Simmeth, E., and Gerisch, G. (2001). Calreticulin and calnexin in the endoplasmic reticulum are important for phagocytosis. EMBO Journal 20, 6772-6782.

Provost, P., Doucet, J., Hammarberg, T., Gerisch, G., Samuelsson, B., and Radmark, O. (2001). 5-Lipoxygenase interacts with Coactosin-Like Protein. Journal of Biological Chemistry 276, 16520-16527

Provost, P., Doucet, J., Stock, A., Gerisch, G., Samuelsson, B., and Radmark, O. (2001). Coactosin-like protein, a human F-actin binding protein: critical role of lysine-75. Biochemical Journal 359, 255-263.

Tuxworth, R.I., Weber, I., Wessels, D., Addicks, G.C., Soll, D.R., Gerisch, G., and Titus, M.A. (2001). A role for myosin VII in dynamic cell adhesion. Current Biology 11, 318-329.

Weber, I. (2001). On the mechanism of cleavage furrow ingression in Dictyostelium. In: Advances in Cytokinesis Research. Cell Structure and Function 26, 577-584 .

2000

Benoit, M., Gabriel, D., Gerisch, G., and Gaub, H. E. (2000). Discrete interactions in cell adhesion measured by single-molecule force spectroscopy. Nature Cell Biology 2, 313-317.

Dumontier, M., Höcht, P., Mintert, U., and Faix, J. (2000). Rac1 GTPases control filopodia formation, cell motility, endocytosis, cytokinesis and development in Dictyostelium. Journal of Cell Science 113, 2253-2265.

Gerisch, G., and Weber, I. (2000). Cytokinesis without myosin II. Current Opinion in Cell Biology (Review) 12, 126-132.

Li, G., Alexander, H., Schneider, N., and Alexander, S. (2000). Molecular basis for resistance to the anticancer drug cisplatin in Dictyostelium. Microbiology 146, 2219-2227.

Merkel, R., Simson, R., Simson, D.A., Hohenadl, M., Boulbitch, A., Wallraff, E., and Sackmann, E. (2000). A micromechanic study of cell polarity and plasma membrane cell body coupling in Dictyostelium. Biophysical Journal 79, 707-719.

Schneider, N., Schwartz, J.-M., Köhler, J., Becker, M., Schwarz, H., and Gerisch, G. (2000). Golvesin-GFP fusions as distinct markers for Golgi and post-Golgi vesicles in Dictyostelium cells. Biology of the Cell 92, 495-511.

Weber, I., Neujahr, R., Du, A., Köhler, J., Faix, J., and Gerisch, G. (2000). Two-step positioning of a cleavage furrow by cortexillin and myosin II. Current Biology 10, 501-506.

Zeng, C., Anjard, C., Riemann, K., Konzok, A., and Nellen W. (2000). gdt1, a new signal transduction component for negative regulation of the growth-differentiation transition in Dictyostelium discoideum. Molecular Biology of the Cell 11, 1631-1643.

1999

Barisic, K., Ecke, M., Heizer, C., Maniak, M., Westphal, M., Albrecht, R., and Gerisch, G. (1999). The actin-associated protein Coronin in chemotaxis, cytokinesis, and phagocytosis of Dictyostelium discoideum. In: GFP in Motion, compiled by Ludin, B., and Matus, A. Trends in Cell Biology 9, supplement on CD-ROM, section cytoskeleton.

Becker, M., Matzner, M., and Gerisch, G. (1999). Drainin required for membrane fusion of the contractile vacuole in Dictyostelium is the prototype of a protein family also represented in man. EMBO Journal 18, 3305-3316.

Faix, J. (1999). Cortexillins. In: Guidebook to the Cytoskeletal and Motor Proteins, 2nd Edition, Eds. Kreis, T., and Vale, R. Oxford University Press, pp. 70-72.

Faix, J. (1999). Contact site A (csA). In: Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins, 2nd Edition, Eds. Kreis, T., and Vale, R. Oxford University Press, pp. 177-179.

Gabriel, D., Hacker, U., Köhler, J., Müller-Taubenberger, A., Schwartz, J.-M., Westphal, M., and Gerisch, G. (1999). The contractile vacuole network of Dictyostelium as a distinct organelle: its dynamics visualized by a GFP marker protein. Journal of Cell Science 112, 3995-4005.

Gerisch, G., Maniak, M., and Neujahr, R. (1999). Patterns of cellular activities based on protein sorting in cell motility, endocytosis and cytokinesis. In: Cell Behaviour: Control and Mechanism of Motility, Biochemical Society Symposium 65, Eds. Lackie, J. M., Dunn, G. A., and Jones, G. E. Portland Press, London, pp. 1-14.

Hanakam, F., and Gerisch, G. (1999). Monitoring intracellular shuttling of histidine-rich pH sensor proteins tagged with green fluorescent protein. Methods in Enzymology 302, 51-58.

Kloboucek, A., Behrisch, A., Faix, J., and Sackmann, E. (1999). Adhesion-induced receptor segregation and adhesion plaque formation: a model membrane study. Biophysical Journal 77, 2311-2328.

Konzok, A., Weber, I., Simmeth, E., Hacker, U., Maniak, M., and Müller-Taubenberger, A. (1999). DAip1, a Dictyostelium homologue of the yeast actin-interacting protein 1, is involved in endocytosis, cytokinesis and motility. Journal of Cell Biology 146, 453-464.

Koonce, M.P., Köhler, J., Neujahr, R., Schwartz, J.-M., Tikhonenko, I., and Gerisch, G. (1999). Dynein motor regulation stabilizes interphase microtubule arrays and determines centrosome position. EMBO Journal 18, 6786-6792.

Maniak, M. (1999). Green fluorescent protein in the visualization of particle uptake and fluid-phase endocytosis. Methods in Enzymology 302, 43-50.

Neujahr, R., Köhler, J., Murphy, J., Schwartz, J.-M., Westphal, M., and Gerisch, G. (1999). Cytokinesis in uni- and multinucleate myosin II-null cells of Dictyostelium discoideum. In: GFP in Motion, compiled by Ludin, B., and Matus, A. Trends in Cell Biology 9, supplement on CD-ROM, section cell division

Noegel, A.A., Rivero, F., Albrecht, R., Janssen, K.-P., Köhler, J., Parent, C.A., and Schleicher, M. (1999). Assessing the role of the ASP56/CAP homologue of Dictyostelium discoideum and the requirements for subcellular localization. Journal of Cell Science 112, 3195-3203.

Rivero, F., Albrecht, R., Dislich, H., Bracco, E., Graciotti, L., Bozzaro, S., and Noegel, A.A. (1999). RacF1, a novel member of the Rho protein family in Dictyostelium discoideum, associates transiently with cell contact areas, macropinosomes, and phagosomes. Molecular Biology of the Cell 10, 1205-1219.

Schneider, N., Gerisch, G., and Schwartz, J.-M. (1999). Microtubule-dependent Golgi disassembly and reconstitution during mitosis in Dictyostelium discoideum. In: GFP in Motion, compiled by Ludin, B., and Matus, A. Trends in Cell Biology 9, supplement on CD-ROM, section cell division.

Schulz, R., Wehmeyer, A., Schulz, K., and Murphy, J. (1999). Effect of phosducin on opioid receptor function. Journal of Pharmacology and Experimental Therapeutics 289, 599-606.

Schulz, R., Wehmeyer, A., Murphy, J., and Schulz, K. (1999). Phosducin, b-arrestin and opioid receptor migration. European Journal of Pharmacology 375, 349-357.

Stock, A., Steinmetz, M.O., Janmey, P.A., Aebi, U., Gerisch, G., Kammerer, R.A., Weber, I., and Faix, J. (1999). Domain analysis of cortexillin I: actin-bundling, PIP2-binding and the rescue of cytokinesis. EMBO Journal 18, 5274-5284.

Weber, I., Gerisch, G., Heizer, C., Murphy, J., Badelt, K., Stock, A., Schwartz, J.-M., and Faix, J. (1999). Cytokinesis mediated through the recruitment of cortexillins into the cleavage furrow. EMBO Journal 18, 586-594.

Weber, I., Niewöhner, J., and Faix, J. (1999). Cytoskeletal protein mutations and cell motility in Dictyostelium. In: Cell Behaviour: Control and Mechanism of Motility, Biochemical Society Symposium 65, Eds. Lackie, J. M., Dunn, G. A., and Jones, G. E. Portland Press, London, pp. 245-265.