Selected Publications

Yuste-Checa, P.; Carvajal, A. I.; Mi, C.; Paatz, S.; Hartl, F.-U.; Bracher, A.: Structural analyses define the molecular basis of clusterin chaperone function. Nature Structural & Molecular Biology 32, pp. 2035 - 2045 (2025)

Kamps, J.; Yuste-Checa, P.; Mamashli, F.; Schmitz, M.; Herrera, M. G.; da Silva Correia, S. M.; Gogte, K.; Bader, V.; Zerr, I.; Hartl, F. U. et al.; Bracher, A.; Winklhofer, K. F.; Tatzelt, J.: Regulated Proteolysis Induces Aberrant Phase Transition of Biomolecular Condensates into Aggregates: A Protective Role for the Chaperone Clusterin. Journal of Molecular Biology 436 (23), 168839 (2024)

Zinzula, L.; Beck, F.; Camasta, M.; Bohn, S.; Liu, C.; Morado, D.; Bracher, A.; Plitzko, J. M.; Baumeister, W.: Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus. Nature Communications 15 (1), 10307 (2024)

Wagner, J.; Bracher, A.: Cage-like complexes that protect folding proteins visualized in cells. Nature (2024)

Wagner, J.; Carvajal Alvarez, A. I.; Bracher, A.; Beck, F.; Wan, W.; Bohn, S.; Körner, R.; Baumeister, W.; Fernandez-Busnadiego, R.; Hartl, F. U.: Visualizing chaperonin function in situ by cryo-electron tomography. Nature 633 (8029), pp. 459 - 464 (2024)

Cairo, L. V.; Hong, X.; Mueller, M. B. D.; Yuste-Checa, P.; Jagadeesan, C.; Bracher, A.; Park, S.-H.; Hayer-Hartl, M.; Hartl, F. U.: Stress-dependent condensate formation regulated by the ubiquitin-related modifier Urm1. Cell 187 (17), pp. 4656 - 4673.e28 (2024)

Schäfer, S. C.; Voll, A. M.; Bracher, A.; Ley, S. V.; Hausch, F.: Antascomicin B stabilizes FKBP51-Akt1 complexes as a molecular glue. Bioorganic & Medicinal Chemistry Letters 104, 129728 (2024)

Zinzula, L.; Mereu, A. M.; Orsini, M.; Seeleitner, C.; Bracher, A.; Nagy, I.; Baumeister, W.: Ebola and Marburg virus VP35 coiled-coil validated as antiviral target by tripartite split-GFP complementation. iScience 25 (11), 105354 (2022)

Yuste-Checa, P.; Bracher, A.; Hartl, F. U.: The chaperone Clusterin in neurodegeneration-friend or foe? Bioessays 44 (7), e2100287 (2022)

Kolos, J. M.; Pomplun, S.; Jung, S.; Riess, B.; Purder, P. L.; Voll, A. M.; Merz, S.; Gnatzy, M.; Geiger, T. M.; Quist-Lokken, I. et al.; Jatzlau, J.; Knaus, P.; Holien, T.; Bracher, A.; Meyners, C.; Czodrowski, P.; Krewald, V.; Hausch, F.: Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides. Chemical Science 12 (44), pp. 14758 - 14765 (2021)

Schneider, M. M.; Gautam, S.; Herling, T. W.; Andrzejewska, E.; Krainer, G.; Miller, A. M.; Trinkaus, V. A.; Peter, Q. A. E.; Ruggeri, F. S.; Vendruscolo, M. et al.; Bracher, A.; Dobson, C. M.; Hartl, F. U.; Knowles, T. P. J.: The Hsc70 disaggregation machinery removes monomer units directly from alpha-synuclein fibril ends. Nature Communications 12 (1), 5999 (2021)

Voll, A. M.; Meyners, C.; Taubert, M. C.; Bajaj, T.; Heymann, T.; Merz, S.; Charalampidou, A.; Kolos, J.; Purder, P. L.; Geiger, T. M. et al.; Wessig, P.; Gassen, N. C.; Bracher, A.; Hausch, F.: Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity. Angewandte Chemie International Edition 60, pp. 2 - 9 (2021)

Yuste-Checa, P.; Trinkaus, V. A.; Riera-Tur, I.; Imamoglu, R.; Schaller, T. F.; Wang, H.; Dudanova, I.; Hipp, M. S.; Bracher, A.; Hartl, F. U.: The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model. Nature Communications 12 (1), 4863 (2021)

Zinzula, L.; Basquin, J.; Bohn, S.; Beck, F.; Klumpe, S.; Pfeifer, G.; Nagy, I.; Bracher, A.; Hartl, F. U.; Baumeister, W.: High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from the Covid-19 severe acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus 2. Biochemical and Biophysical Research Communications 538, pp. 54 - 62 (2021)

Flecken, M.; Wang, H.; Popilka, L.; Hartl, F. U.; Bracher, A.; Hayer-Hartl, M.: Dual Functions of a Rubisco Activase in Metabolic Repair and Recruitment to Carboxysomes. Cell 183 (2), pp. 457 - 473.e20 (2020)

Bracher, A.; Paul, S. S.; Wang, H.; Wischnewski, N.; Hartl, F. U.; Hayer-Hartl, M.: Structure and conformational cycle of a bacteriophage-encoded chaperonin. PLOS ONE 15 (4), e0230090 (2020)

Mönkemeyer, L.; Klaips, C. L.; Balchin, D.; Körner, R.; Hartl, F. U.; Bracher, A.: Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2. Molecular Cell 74 (1), pp. 88 - 100.e9 (2019)

Wang, H.; Yan, X.; Aigner, H.; Bracher, A.; Nguyen, N. D.; Hee, W. Y.; Long, B. M.; Price, G. D.; Hartl, F. U.; Hayer-Hartl, M.: Rubisco condensate formation by CcmM in beta-carboxysome biogenesis. Nature 566 (7742), pp. 131 - 135 (2019)

Wilson, R. H.; Hayer-Hartl, M.; Bracher, A.: Crystal structure of phosphoribulokinase from Synechococcus sp. strain PCC 6301. Acta Crystallographica Section F: Structural Biology Communications 75 (4), pp. 278 - 289 (2019)

Zinzula, L.; Nagy, I.; Orsini, M.; Weyher-Stingl, E.; Bracher, A.; Baumeister, W.: Structures of Ebola and Reston Virus VP35 Oligomerization Domains and Comparative Biophysical Characterization in All Ebolavirus Species. Structure 27 (1), pp. 39 - 54.e6 (2019)