Publications

Lu, Y.; Schuller, M.; Bullen, N. P.; Mikolcevic, P.; Zonjic, I.; Raggiaschi, R.; Mikoc, A.; Whitney, J. C.; Ahel, I.: Discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence module against toxic attack. Nucleic Acids Research 53 (4), gkaf069 (2025)

Cihlova, B.; Lu, Y.; Mikoc, A.; Schuller, M.; Ahel, I.: Specificity of DNA ADP-Ribosylation Reversal by NADARs. Toxins 16 (5), 208 (2024)

Kar, P.; Chatrin, C.; Dukic, N.; Suyari, O.; Schuller, M.; Zhu, K.; Prokhorova, E.; Bigot, N.; Ahel, J.; Elsborg, J. D. et al.; Nielsen, M. L.; Clausen, T.; Huet, S.; Niepel, M.; Sanyal, S.; Ahel, D.; Smith, R.; Ahel, I.: PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation. The EMBO Journal 43 (14), pp. 2929 - 2953 (2024)

Wondisford, A. R.; Lee, J.; Lu, R.; Schuller, M.; Groslambert, J.; Bhargava, R.; Schamus-Haynes, S.; Cespedes, L. C.; Opresko, P. L.; Pickett, H. A. et al.; Min, J.; Ahel, I.; O'Sullivan, R. J.: Deregulated DNA ADP-ribosylation impairs telomere replication. Nature Structural & Molecular Biology 31 (5), pp. 791 - 800 (2024)

Dukic, N.; Stromland, O.; Elsborg, J. D.; Munnur, D.; Zhu, K.; Schuller, M.; Chatrin, C.; Kar, P.; Duma, L.; Suyari, O. et al.; Rack, J. G. M.; Baretic, D.; Crudgington, D. R. K.; Groslambert, J.; Fowler, G.; Wijngaarden, S.; Prokhorova, E.; Rehwinkel, J.; Schuler, H.; Filippov, D. V.; Sanyal, S.; Ahel, D.; Nielsen, M. L.; Smith, R.; Ahel, I.: PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities. Science Advances 9 (37), eadi2687 (2023)

Gahbauera, S.; Correy, G. J.; Schuller, M.; Ferlad, M. P.; Doruk, Y. U.; Rachman, M.; Wu, T.; Diolaiti, M.; Wang, S.; Neitz, R. J. et al.; Fearon, D.; Radchenko, D. S.; Moroz, Y. S.; Irwin, J. J.; Renslo, A. R.; Taylor, J. C.; Gestwicki, J. E.; von Delft, F.; Ashworth, A.; Ahel, I.; Shoichet, B. K.; Fraser, J. S.: Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2), e2212931120 (2023)

Longarini, E. J.; Dauben, H.; Locatelli, C.; Wondisford, A. R.; Smith, R.; Muench, C.; Kolvenbach, A.; Lynskey, M. L.; Pope, A.; Bonfiglio, J. J. et al.; Jurado, E. P.; Fajka-Boja, R.; Colby, T.; Schuller, M.; Ahel, I.; Timinszky, G.; O’Sullivan, R. J.; Huet, S.; Matic, I.: Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling. Molecular Cell 83, pp. 1743 - 1760 (2023)

Schuller, M.; Raggiaschi, R.; Mikolcevic, P.; Rack, J. G. M.; Ariza, A.; Zhang, Y.; Ledermann, R.; Tang, C.; Mikoc, A.; Ahel, I.: Molecular basis for the reversible ADP-ribosylation of guanosine bases. Molecular Cell 83 (13), pp. 2303 - 2315 (2023)

Schuller, M.; Zarganes-Tzitzikas, T.; Bennett, J.; De Cesco, S.; Fearon, D.; von Delft, F.; Fedorov, O.; Brennan, P. E. E.; Ahel, I.: Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors. Pathogens 12 (2), 324 (2023)

Suskiewicz, M. J.; Munnur, D.; Stromland, O.; Yang, J.-C.; Easton, L. E.; Chatrin, C.; Zhu, K.; Baretic, D.; Goffinont, S.; Schuller, M. et al.; Wu, W.-F.; Elkins, J. M.; Ahel, D.; Sanyal, S.; Neuhaus, D.; Ahel, I.: Updated protein domain annotation of the PARP protein family sheds new light on biological function. Nucleic Acids Research 51 (15), pp. 8217 - 8236 (2023)

Hlousek-Kasun, A.; Mikolcevic, P.; Rack, J. G. M.; Tromans-Coia, C.; Schuller, M.; Jankevicius, G.; Matkovic, M.; Bertosa, B.; Ahel, I.; Mikoc, A.: Streptomyces coelicolor macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA. Computational and Structural Biotechnology Journal 20, pp. 4337 - 4350 (2022)

Schuller, M.; Ahel, I.: Beyond protein modification: the rise of non-canonical ADP-ribosylation. Biochemical Journal 479 (4), pp. 463 - 477 (2022)

Bajusz, D.; Wade, W. S.; Satala, G.; Bojarski, A. J.; Ilas, J.; Ebner, J.; Grebien, F.; Papp, H.; Jakab, F.; Douangamath, A. et al.; Fearon, D.; von Delft, F.; Schuller, M.; Ahel, I.; Wakefield, A.; Vajda, S.; Gerencser, J.; Pallai, P.; Keseru, G. M.: Exploring protein hotspots by optimized fragment pharmacophores. Nature Communications 12 (1), 3201 (2021)

Schuller, M.; Butler, R. E.; Ariza, A.; Tromans-Coia, C.; Jankevicius, G.; Claridge, T. D. W.; Kendall, S. L.; Goh, S.; Stewart, G. R.; Ahel, I.: Molecular basis for DarT ADP-ribosylation of a DNA base. Nature 596 (7873), pp. 597 - 602 (2021)

Schuller, M.; Correy, G. J.; Gahbauer, S.; Fearon, D.; Wu, T.; Diaz, R. E.; Young, I. D.; Martins, L. C.; Smith, D. H.; Schulze-Gahmen, U. et al.; Owens, T. W.; Deshpande, I.; Merz, G. E.; Thwin, A. C.; Biel, J. T.; Peters, J. K.; Moritz, M.; Herrera, N.; Kratochvil, H. T.; Aimon, A.; Bennett, J. M.; Neto, J. B.; Cohen, A. E.; Dias, A.; Douangamath, A.; Dunnett, L.; Fedorov, O.; Ferla, M. P.; Fuchs, M. R.; Gorrie-Stone, T. J.; Holton, J. M.; Johnson, M. G.; Krojer, T.; Meig, G.; Powell, A. J.; Rack, J. G. M.; Rangel, V. L.; Russi, S.; Skyner, R. E.; Smith, C. A.; Soares, A. S.; Wierman, J. L.; Zhu, K.; O'Brien, P.; Jura, N.; Ashworth, A.; Irwin, J. J.; Thompson, M. C.; Gestwicki, J. E.; von Delft, F.; Shoichet, B. K.; Fraser, J. S.; Ahel, I.: Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Science Advances 7 (16), eabf8711 (2021)

Rack, J. G. M.; Zorzini, V.; Zhu, Z.; Schuller, M.; Ahel, D.; Ahel, I.: Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential. Open Biology 10 (11), 200237 (2020)

Moustakim, M.; Riedel, K.; Schuller, M.; Gehring, A. P.; Monteiro, O. P.; Martin, S. P.; Fedorov, O.; Heer, J.; Dixon, D. J.; Elkins, J. M. et al.; Knapp, S.; Bracher, F.; Brennan, P. E.: Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. Bioorganic & Medicinal Chemistry 26 (11), pp. 2965 - 2972 (2018)

Schuller, M.; Hoefner, G.; Wanner, K. T.: Simultaneous Multiple MS Binding Assays Addressing D1 and D2 Dopamine Receptors. ChemMedChem 12 (19), pp. 1585 - 1594 (2017)

Schuller, M.; Riede, K.; Gibbs-Seymour, I.; Uth, K.; Sieg, C.; Gehring, A. P.; Ahel, I.; Bracher, F.; Kessler, B. M.; Elkins, J. M. et al.; Knapp, S.: Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. ACS Chemical Biology 12 (11), pp. 2866 - 2874 (2017)

Froese, D. S.; Kopec, J.; Fitzpatrick, F.; Schuller, M.; McCorvie, T. J.; Chalk, R.; Plessl, T.; Fettelschoss, V.; Fowler, B.; Baumgartner, M. R. et al.; Yue, W. W.: Structural Insights into the MMACHC-MMADHC Protein Complex Involved in Vitamin B12 Trafficking. Journal of Biological Chemistry 290 (49), pp. 29167 - 29177 (2015)