Publications of T. A. Holak
All genres
Journal Article (78)
21.
Journal Article
2 (4), pp. 246 - 260 (2011)
The p53-MDM2/MDMX axis - A chemotype perspective. Medchemcomm 22.
Journal Article
50 (12), pp. 2680 - 2688 (2011)
The Structure-Based Design of Mdm2/Mdmx-p53 Inhibitors Gets Serious. Angewandte Chemie-International Edition 23.
Journal Article
76 (2), pp. 116 - 129 (2010)
1,4-Thienodiazepine-2,5-diones via MCR (I): Synthesis, Virtual Space and p53-Mdm2 Activity. Chemical Biology & Drug Design 24.
Journal Article
107 (26), pp. 11757 - 11762 (2010)
Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proceedings of the National Academy of Sciences of the United States of America 25.
Journal Article
9 (6), pp. 1104 - 1111 (2010)
Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. Cell Cycle 26.
Journal Article
49 (31), pp. 5352 - 5356 (2010)
Robust Generation of Lead Compounds for Protein-Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists. Angewandte Chemie-International Edition 27.
Journal Article
284 (46), pp. 31664 - 31671 (2009)
Structures of the Arm-type Binding Domains of HPI and HAI7 Integrases. Journal of Biological Chemistry 28.
Journal Article
11 (4), pp. 631 - 639 (2009)
Rapid and Efficient Hydrophilicity Tuning of p53/mdm2 Antagonists. Journal of Combinatorial Chemistry 29.
Journal Article
131 (22), pp. 7500 - 7501 (2009)
Robust NMR Screening for Lead Compounds Using Tryptophan-Containing Proteins. Journal of the American Chemical Society 30.
Journal Article
8 (8), pp. 1176 - 1184 (2009)
High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle 31.
Journal Article
284 (6), pp. 4031 - 4039 (2009)
c-Abl Phosphorylates Hdmx and Regulates Its Interaction with p53. Journal of Biological Chemistry 32.
Journal Article
51 (16), pp. 5035 - 5042 (2008)
NMR screening for lead compounds using tryptophan-mutated proteins. Journal of Medicinal Chemistry 33.
Journal Article
7 (15), pp. 2441 - 2443 (2008)
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. Cell Cycle 34.
Journal Article
5 (7), pp. 605 - 607 (2008)
Lifeact: a versatile marker to visualize F-actin. Nature Methods 35.
Journal Article
3 (7), pp. 1118 - 1128 (2008)
Isoquinolin-1-one inhibitors of the MDM2-p53 interaction. ChemMedChem 36.
Journal Article
64 (19-20), pp. 2702 - 2715 (2007)
CAP2, cyclase-associated protein 2, is a dual compartment protein. Cellular and Molecular Life Sciences 37.
Journal Article
6 (19), pp. 2386 - 2392 (2007)
Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle 38.
Journal Article
23 (19), pp. 2536 - 2542 (2007)
Protein solubility: sequence based prediction and experimental verification. Bioinformatics 39.
Journal Article
50 (18), pp. 4382 - 4387 (2007)
An NMR-Based antagonist induced dissociation assay for targeting the ligand-protein and protein-protein interactions in competition binding experiments. Journal of Medicinal Chemistry 40.
Journal Article
8 (11), pp. 1308 - 1316 (2007)
Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex. ChemBioChem