Publications
Gaidt, M. M., T. S. Ebert, D. Chauhan, K. Ramshorn, F. Pinci, S. Zuber, F. O'Duill, J. L. Schmid-Burgk, F. Hoss, R. Buhmann, G. Wittmann, E. Latz, M. Subklewe and V. Hornung. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3 Cell, 2017;
Kim-Hellmuth, S., M. Bechheim, B. Putz, P. Mohammadi, Y. Nedelec, N. Giangreco, J. Becker, V. Kaiser, N. Fricker, E. Beier, P. Boor, S. E. Castel, M. M. Nothen, L. B. Barreiro, J. K. Pickrell, B. Muller-Myhsok, T. Lappalainen, J. Schumacher and V. Hornung. Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations Nat Commun, 2017; 8: 266
van den Boorn, J. G., C. Jakobs, C. Hagen, M. Renn, R. M. Luiten, C. J. Melief, T. Tuting, N. Garbi, G. Hartmann and V. Hornung. Inflammasome-Dependent Induction of Adaptive NK Cell Memory Immunity, 2016; 44: 1406-21
Gaidt, M. M., T. S. Ebert, D. Chauhan, T. Schmidt, J. L. Schmid-Burgk, F. Rapino, A. A. Robertson, M. A. Cooper, T. Graf and V. Hornung. Human Monocytes Engage an Alternative Inflammasome Pathway Immunity, 2016; 44: 833-46
Ablasser, A., J. L. Schmid-Burgk, I. Hemmerling, G. L. Horvath, T. Schmidt, E. Latz and V. Hornung. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP Nature, 2013; 503: 530-4
Ablasser, A., M. Goldeck, T. Cavlar, T. Deimling, G. Witte, I. Rohl, K. P. Hopfner, J. Ludwig and V. Hornung. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING Nature, 2013; 498: 380-4
Bartok, E., F. Bauernfeind, M. G. Khaminets, C. Jakobs, B. Monks, K. A. Fitzgerald, E. Latz and V. Hornung. iGLuc: a luciferase-based inflammasome and protease activity reporter Nat Methods, 2013; 10: 147-154
Schmid-Burgk, J. L., T. Schmidt, V. Kaiser, K. Honing and V. Hornung. A ligation-independent cloning technique for high-throughput assembly of transcription activator-like effector genes Nat Biotechnol, 2013; 31: 76-81
Duewell, P., H. Kono, K. J. Rayner, C. M. Sirois, G. Vladimer, F. G. Bauernfeind, G. S. Abela, L. Franchi, G. Nunez, M. Schnurr, T. Espevik, E. Lien, K. A. Fitzgerald, K. L. Rock, K. J. Moore, S. D. Wright, V. Hornung and E. Latz. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals Nature, 2010; 464: 1357-61
Ablasser, A., F. Bauernfeind, G. Hartmann, E. Latz, K. A. Fitzgerald and V. Hornung. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate Nat Immunol, 2009; 10: 1065-72
Hornung, V., A. Ablasser, M. Charrel-Dennis, F. Bauernfeind, G. Horvath, D. R. Caffrey, E. Latz and K. A. Fitzgerald. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC Nature, 2009; 458: 514-8
Hornung, V., F. Bauernfeind, A. Halle, E. O. Samstad, H. Kono, K. L. Rock, K. A. Fitzgerald and E. Latz. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization Nat Immunol, 2008; 9: 847-56
Hornung, V., J. Ellegast, S. Kim, K. Brzozka, A. Jung, H. Kato, H. Poeck, S. Akira, K. K. Conzelmann, M. Schlee, S. Endres and G. Hartmann. 5'-Triphosphate RNA is the ligand for RIG-I Science, 2006; 314: 994-7
Hornung, V., M. Guenthner-Biller, C. Bourquin, A. Ablasser, M. Schlee, S. Uematsu, A. Noronha, M. Manoharan, S. Akira, A. de Fougerolles, S. Endres and G. Hartmann. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7 Nat Med, 2005; 11: 263-70
Recent Reviews
Roers, A., B. Hiller and V. Hornung. Recognition of Endogenous Nucleic Acids by the Innate Immune System Immunity, 2016; 44: 739-54
Hornung, V. SnapShot: Nucleic acid immune sensors, part 2 Immunity, 2014; 41: 1066-1066 e1
Hornung, V. SnapShot: nucleic acid immune sensors, part 1 Immunity, 2014; 41: 868, 868 e1
Hornung, V., R. Hartmann, A. Ablasser and K. P. Hopfner. OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids Nat Rev Immunol, 2014; 14: 521-8