Measuring the tRNA world by mim-tRNAseq

Research report (imported) 2021 - Max Planck Institute of Biochemistry

Behrens, Andrew; Rodschinka, Geraldine; Nedialkova, Danny
Forschungsgruppe Mechanismen der Proteinbiogenese
Transfer RNAs (tRNAs) specifically deliver amino acids to ribosomes during the translation of messenger RNA (mRNA) into proteins. The abundance of tRNAs therefore has a profound impact on cells. However, determining the amount of each tRNA species in cells was limited because of technical challenges. We overcame these limitations thanks to mim-tRNAseq, a method that can be used to quantify tRNAs in any organism and will help improve our understanding of tRNA regulation in health and disease.

For the full text, see the German version.

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