Molecular Medicine

Research report (imported) 2003 - Max Planck Institute of Biochemistry

Fässler, Reinhard
We investigate integrin-mediated adhesion in various tissues of mice. To this end we establish mouse models with targeted mutations in extracellular matrix proteins, integrins and integrin-associated proteins. The consequence of the mutations are analyzed during mouse development, which allows to assess the physiological function of the mutant gene, and disease situations such as inflammation tissue repair and tumor formation.

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