The correct protein folding is crucial for their function inside the cell. However, most of the proteins can be folded in millions of ways. But only one arrangement of these long amino acid chains is correct. In his Research Department “Cellular Biochemistry” Ulrich Hartl and his team are investigating how this cellular origami works and what happens if something goes wrong. As the film illustrates, the underlying mechanisms and the structure of the involved molecules are particularly in the focus of the researchers.