Small RNA-guided gene silencing

Research report (imported) 2009 - Max Planck Institute of Biochemistry

Meister, Gunter
RNA Biologie (Meister, MPI) (Dr. Gunter Meister)
MPI für Biochemie, Martinsried
The genetic information encoded by DNA is transcribed to mRNA molecules which are subsequently translated into proteins. However, only a minor portion of the human genome encodes for proteins. The bulk of the human DNA is non-coding. Interestingly, non-coding DNA is constantly transcribed into non-coding RNA and it was found that such non-coding RNAs have fundamental cellular functions. Extensive research of the past years revealed that non-coding RNAs can also play important roles in the pathogenesis of diseases including various forms of cancer.

For the full text, see the German version.

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