Regulation of genome stability by ubiquitin and SUMO

Research report (imported) 2010 - Max Planck Institute of Biochemistry

Jentsch, Stefan
Abteilung Molekulare Zellbiologie
Max-Planck-Institut für Biochemie
Modification of proteins can alter their function. If proteins are modified by the small protein ubiquitin, the proteins are usually targeted for degradation. However, our work has shown that ubiquitin and its related protein SUMO can also mediate DNA repair and genome stability. In human, this mechanism is important to avoid tumor formation.

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