Press releases 2016

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The battery compartments of the 26S Protein Recycling Machine

June 27, 2016
 The degradation of proteins and the re-use of their basic building blocks is a process that is a matter of survival in cells. Researchers at the Max-Planck-Institute for Biochemistry present a detailed structure of the human protein recycling machine, the so-called 26S proteasome, in near-atomic resolution in their latest article published in PNAS. The high-resolution structure enabled the scientists to visualize the molecular energy carriers bound to the 26S proteasome, which provide the power for proteasome function. Detailed knowledge of the exact structure is the basis for the development of drugs for the treatment of cancers and neurodegenerative diseases.   [more]
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MPIB Scientist becomes EMBO Member

May 23, 2016
Today, the European Molecular Biology Organization, EMBO announced Manajit Hayer-Hartl, next to 57 scientist from 18 countries, as a new member of the Organization. Hayer-Hartl is head of the Research Group “Chaperonin-assisted Protein Folding” at the Max Planck Institute of Biochemistry in Martinsried. EMBO stands for cutting-edge research in the life sciences in Europe and worldwide. New members are exclusively nominated and elected by the current 1700 EMBO Members and associated Members. [more]
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Proteins for export – cellar distribution centre

May 09, 2016
Proteins complete certain tasks both within and outside cells, like small machines. For example, the COMP and LysC proteins are active in intercellular spaces. But how do these proteins reach their action site following their synthesis in the cell interior? Julia von Blume, who is head of the “Molecular Basis of Protein Trafficking” research group at the Max Planck Institute of Biochemistry in Martinsried, has now succeeded in demonstrating that calcium and the transport protein Cab45 play a central role in the functioning of a special department of the Golgi apparatus, the cell’s distribution centre. The inflow of the calcium signal into the Golgi apparatus causes the Cab45 protein to change shape, accumulate and only come into contact with proteins that carry out their work outside the cell. Hence Cab45 is a central component of the previously unknown sorting mechanism in the cellular export department. [more]
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Max Planck Foundation pledges one million euros to scientists

April 25, 2016
Two Research Groups from the Max Planck Institute of Biochemistry in Martinsried are set to receive approximately one million euros from the Max Planck Foundation to fund an innovative research approach. F.-Ulrich Hartl, an expert in neurodegenerative diseases, and Ralf Jungmann, who has developed the super-high resolution microscopy method DNA-PAINT, plan to combine their expertise. The researchers would like to make the complex network of proteins involved in the pathological process of Alzheimer’s disease visible. DNA-PAINT can visualize the unknown molecular interactions at a high spatial resolution, thereby providing the basis for the development of new therapeutic approaches. [more]
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ERC-Grant for Reseach Group Leader

April 19, 2016
Ralf Jungmann was granted the much valued Starting Grant of the European Research Council with 1.5 million Euros. With his developed super-resolution microscope technique DNA-PAINT he wants to make the molecular network of numerous RNA and protein interactions visible in cells and tissue. Jungmann is junior research group leader at the Max-Planck-Institute of Biochemistry and the LMU. The LMU reported: [more]
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Multiplexed Morse signals from cells

March 28, 2016
How many sorts, in how many copies? The biochemical processes that take place in cells require specific molecules to congregate and interact in specific locations. A novel type of high-resolution microscopy developed at the Max Planck Institute of Biochemistry in Martinsried and Harvard University, USA, already allows researchers to visualize these molecular complexes and identify their constituents. Now they can also determine the numbers of each molecular species in these structures. Such quantitative information is valuable for the understanding of cellular mechanisms and how they are altered in disease states. The new technique is described in Nature Methods. [more]
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Protein atlas of fly cells

March 07, 2016
The human genome codes for more than 20,000 different proteins, however the molecular role for many of these proteins is not known. As most proteins are conserved from fly to humans, understanding the molecular role of a protein in flies can be the first step towards a therapy against a variety of human diseases that are often caused by aberrantly behaving proteins. A consortium of scientists from the Max Planck Institutes of Biochemistry in Martinsried and Molecular Cell Biology and Genetics in Dresden, and the National Centre for Biological Sciences (NCBS) in Bangalore have now reached a milestone towards understanding the function of these proteins by using the fruit fly. [more]
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