Brenda Schulman, Ph.D.
Phone:+49 89 8578

MPI of Biochemistry, Am Klopferspitz 18, 82152 Martinsried

Molecular Machines and Signaling

Dr. Josef Kellermann
Chief Scientific Administrator
Phone:+49 89 8578-2484

Molecular Machines and Signaling

Research Department "Molecular Machines and Signaling "

A major form of eukaryotic regulation involves protein and membrane linkage to the small protein ubiquitin, or to structurally-related ubiquitin-like proteins (UBLs).  Ubiquitin and UBLs control timing, subcellular location, assembly, conformation, and other properties of thousands of different human proteins and macromolecules.  Moreover, defects in ubiquitin and UBL pathways are associated with numerous diseases including cancers, neurodegenerative disorders, and viral infections.  Our department integrates biochemistry, structural biology, chemistry, biophysics, genetics and cell biology to decipher signaling by ubiquitin and UBLs.  Our goals are to define fundamental mechanisms underlying how dynamic, multiprotein assemblies called “molecular machines” match particular forms of ubiquitin and UBLs with their specific cellular targets, and to elucidate how ubiquitin and UBLs remodel the structures and switch the functions of their targets to regulate cell division, protein trafficking, metabolic signaling and autophagy

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