Brenda Schulman

Brenda Schulman

Research Department Molecular Machines and Signaling (MoMaS)

Structural Biology, Ubiquitin Proteasome System, Ubiquitin-like Protein

An important form of regulation is the modification of proteins and membranes by linking them to the small protein ubiquitin or structurally related ubiquitin-like proteins (UBLs). Ubiquitin and UBLs control timing, subcellular location, composition, conformation and activity of thousands of different proteins and macromolecules. In addition, defects in ubiquitin and UBL pathways are associated with numerous diseases such as cancer, neurodegenerative disorders and viral infections. Brenda Schulman's Department “Molecular Machines and Signaling” has shown that hundreds of microscopic, dynamic, multiprotein molecular machines are transiently transformed into different conformations by specialized regulatory factors to control ubiquitin and UBLs in order to regulate virtually all aspects of cell biology.

 

Research Overview
A widespread mechanism regulating the functions of eukaryotic proteins involves post-translational modification by the small protein ubiquitin (UB) or structurally related ubiquitin-like proteins (UBLs). more

 

Department News

Combinatorial selective ER-phagy remodels the ER during neurogenesis
01.03.2024
New Publication & Journal Cover -
Congratulations to Cristina and Anna! And thanks to collaborators Melissa and Wade for visiting and making this happen
@ Aligning Science Across Parkinson’s (ASAP) Team Harper more
Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
20.02.2024
New Publication -
Congratulations to Joanna, Ishita, Rajan and collaborators! Amazing this started from Gary’s summer sabbatical!
Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases
07.02.2024
New Publication
- Congratulations to Joanna, Sam, David, Rajan and the summer member of the lab Gary!
-> Press Release: How cells sort their trash
Targeted Protein Degradation
21-24.01.2024
Brenda (organizer and speaker), Jakub (poster), and Laura (poster) participated the symposium in Colorado!

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