Contact

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Prof. Dr. Karl Duderstadt
Group Leader
Phone:+49 89 8578-3033

MPI of Biochemistry,
Am Klopferspitz 18, 82152 Martinsried

http://www.biochem.mpg.de/duderstadt

Research Group "Structure and Dynamics of Molecular Machines"

Cell proliferation and survival critically depend on an array of carefully orchestrated control mechanisms to ensure that replication proceeds efficiently, gene expression patterns are maintained across cell generations, and chromosomes are preserved. Errors arising in these control mechanisms are implicated in many diseases, making their study of critical importance. Research in our group is focused on understanding how macromolecular complexes responsible for DNA replication are organized and how enzymatic events at the replication fork are dynamically coordinated to ensure chromosome integrity. To understand these processes, we employ a combination of structural, biochemical, and single-molecule methods to generate mechanistic models of how critical nucleic acid transactions are conducted.

 

 
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