Publications of Brenda Schulman

Qiao, S.; Lee, C.-W.; Sherpa, D.; Chrustowicz, J.; Cheng, J. D.; Duennebacke, M.; Steigenberger, B.; Karayel, O.; Tung Vu, D.; Gronau, S. v. et al.; Mann, M.; Wilfling, F.; Schulman, B.: Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation. Nature Communications 13 (1), 3041 (2022)

Bludau, I.; Willems, S.; Zeng, W.-F.; Strauss, M. T.; Hansen, F. M.; Tanzer, M. C.; Karayel, O.; Schulman, B. A.; Mann, M.: The structural context of posttranslational modifications at a proteome-wide scale. PLoS Biology 20 (5), e3001636 (2022)

Sherpa, D.; Chrustowicz, J.; Schulman, B.: How the ends signal the end: Regulation by E3 ubiquitin ligases recognizing protein termini. Molecular Cell 82 (8), pp. 1424 - 1438 (2022)

Langlois, C. R.; Beier, V.; Karayel, O.; Chrustowicz, J.; Sherpa, D.; Mann, M.; Schulman, B. A.: A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters. EMBO Reports 23, e53835 (2022)

Horn-Ghetko, D.; Schulman, B. A.: New classes of E3 ligases illuminated by chemical probes. Current Opinion in Structural Biology 73, 102341 (2022)

Chrustowicz, J.; Sherpa, D.; Teyra, J.; Loke, M. S.; Popowicz, G. M.; Basquin, J.; Sattler, M.; Prabu, J. R.; Sidhu, S. S.; Schulman, B.: Multifaceted N-Degron Recognition and Ubiquitylation by GID/CTLH E3 Ligases. Journal of Molecular Biology 434 (2), 167347 (2022)

Cable, J.; Weber-Ban, E.; Clausen, T.; Walters, K. J.; Sharon, M.; Finley, D. J.; Gu, Y.; Hanna, J.; Feng, Y.; Martens, S. et al.; Simonsen, A.; Hansen, M.; Zhang, H.; Goodwin, J. M.; Reggio, A.; Chang, C.; Ge, L.; Schulman, B. A.; Deshaies, R. J.; Dikic, I.; Harper, J. W.; Wertz, I. E.; Thoma, N. H.; Slabicki, M.; Frydman, J.; Jakob, U.; David, D. C.; Bennett, E. J.; Bertozzi, C. R.; Sardana, R.; Eapen, V. V.; Carra, S.: Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report. Annals of the New York Academy of Sciences 1510, pp. 79 - 99 (2022)

Ferguson, C. J.; Urso, O.; Bodrug, T.; Gassaway, B. M.; Watson, E. R.; Prabu, J. R.; Lara-Gonzalez, P.; Martinez-Chacin, R. C.; Wu, D. Y.; Brigatti, K. W. et al.; Puffenberger, E. G.; Taylor, C. M.; Haas-Givler, B.; Jinks, R. N.; Strauss, K. A.; Desai, A.; Gabel, H. W.; Gygi, S. P.; Schulman, B. A.; Brown, N. G.; Bonni, A.: APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. Molecular Cell 82 (1), pp. 90 - 105 (2022)

Pluska, L.; Jarosch, E.; Zauber, H.; Kniss, A.; Waltho, A.; Bagola, K.; von Delbrueck, M.; Loehr, F.; Schulman, B. A.; Selbach, M. et al.; Doetsch, V.; Sommer, T.: The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63-branched ubiquitin chains. EMBO Journal 40 (6), e106094 (2021)

Baek, K.; Scott, D. C.; Schulman, B. A.: NEDD8 and ubiquitin ligation by cullin-RING E3 ligases. Current Opinion in Structural Biology 67, pp. 101 - 109 (2021)

Davis, B.; Backus, K.; Winter, G.; Chica, R.; Li, D.; Lee, S. Y.; He, C.; Weeks, A.; Overall, C.; Hagihara, S. et al.; Thuronyi, B.; Kamat, S.; Chen, L.-L.; Hurtado Guerrero, R.; Yao, S.; Mahal, L. K.; Voigt, C.; Woo, C.; Strauss, E.; Kikuchi, K.; Dore, T.; Radford, S.; Li, X. D.; Heo, W. D.; Superti-Furga, G.; Deans, T.; Belousov, V.; Matthews, M.; Jackson, C.; Malek, S.; Waldmann, H.; Rising, A.; Jewett, M.; Stamou, D.; Parker, E.; Murakami, M.; Polizzi, K.; Hamachi, I.; Erb, T.; Joo, C.; Uesugi, M.; Prinjha, R.; Rechavi, G.; Solano, R.; Schulman, B.; David, Y.; Oslund, R.: Voices of chemical biology. Nature Chemical Biology 17 (1), pp. 1 - 4 (2021)

Hansen, F. M.; Tanzer, M. C.; Brüning, F.; Bludau, I.; Stafford, C.; Schulman, B. A.; Robles, M. S.; Karayel, O.; Mann, M.: Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology. Nature Communications 12 (1), 254 (2021)

Heider, L.; Eichner, R.; Stroh, J.; Morath, V.; Kuisl, A.; Zecha, J.; Lawatscheck, J.; Baek, K.; Garz, A.-K.; Rudelius, M. et al.; Deuschle, F.-C.; Keller, U.; Lemeer, S.; Verbeek, M.; Gotze, K. S.; Skerra, A.; Weber, W. A.; Buchner, J.; Schulman, B. A.; Kuster, B.; Fernandez-Saiz, V.; Bassermann, F.: The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma. Molecular Cell 81 (6), pp. 1170 - 1186.e10 (2021)

Henneberg, L. T.; Schulman, B. A.: Decoding the messaging of the ubiquitin system using chemical and protein probes. Cell Chemical Biology 28 (7), pp. 889 - 902 (2021)

Horn-Ghetko, D.; Krist, D. T.; Prabu, J. R.; Baek, K.; Mulder, M. P. C.; Kluegel, M.; Scott, D. C.; Ovaa, H.; Kleiger, G.; Schulman, B.: Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly. Nature 590 (7847), pp. 671 - 676 (2021)

Kim, H. S.; Hammill, J. T.; Scott, D. C.; Chen, Y.; Rice, A. L.; Pistel, W.; Singh, B.; Schulman, B. A.; Guy, R. K.: Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M. Journal of Medicinal Chemistry 64 (9), pp. 5850 - 5862 (2021)

Kostrhon, S.; Prabu, J. R.; Baek, K.; Horn-Ghetko, D.; Gronau, S. v.; Klügel, M.; Basquin, J.; Alpi, A. F.; Schulman, B. A.: CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation. Nature Chemical Biology 17 (10), pp. 1075 - 1083 (2021)

Liwocha, J.; Krist, D. T.; van der Heden van Noort, G.J.; Hansen, F. M.; Truong, V.H.; Karayel, O.; Purser, N.; Houston, D.; Burton, N.; Bostock, M.J. et al.; Sattler, M.; Mann, M.; Harrison, J.S.; Kleiger, G.; Ovaa, H.; Schulman, B. A.: Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. Nature Chemical Biology 17, pp. 272 - 279 (2021)

Schulman, B. A.; Harper, J. W.: Cell biology Host ubiquitin protein tags lipid to fight bacteria. Nature 594 (7861), pp. 28 - 29 (2021)

Sherpa, D.; Chrustowicz, J.; Qiao, S.; Langlois, C. R.; Hehl, L. A.; Gottemukkala, K. V.; Hansen, F. M.; Karayel, O.; von Gronau, S.; Prabu, J. R. et al.; Mann, M.; Alpi, A. F.; Schulman, B. A.: GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Molecular Cell 81 (11), pp. 2445 - 2459.e13 (2021)