Publications of Konstanze F. Winklhofer

Journal Article (21)

1.
Journal Article
Woerner, A. C.; Frottin, F.; Hornburg, D.; Feng, L. R.; Meissner, F.; Patra, M.; Tatzelt, J.; Mann, M.; Winklhofer, K. F.; Hartl, F. U. et al.; Hipp, M. S.: Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA. Science 351 (6269), pp. 173 - 176 (2016)
2.
Journal Article
Resenberger, U. K.; Harmeier, A.; Woerner, A. C.; Goodman, J. L.; Müller, V.; Krishnan, R.; Vabulas, R. M.; Kretzschmar, H. A.; Lindquist, S.; Hartl, F. U. et al.; Multhaup, G.; Winklhofer, K. F.; Tatzelt, J.: The cellular prion protein mediates neurotoxic signalling of beta-sheet-rich conformers independent of prion replication. EMBO Journal 30 (10), pp. 2057 - 2070 (2011)
3.
Journal Article
Schumacher, M. C.; Resenberger, U.; Seidel, R. P.; Becker, C. F. W.; Winklhofer, K. F.; Oesterhelt, D.; Tatzelt, J.; Engelhard, M.: Synthesis of a GPI Anchor Module Suitable for Protein Post-Translational Modification. Biopolymers 94 (4 Sp. Iss.), pp. 457 - 464 (2010)
4.
Journal Article
Rambold, A. S.; Miesbauer, M.; Olschewski, D.; Seidel, R.; Riemer, C.; Smale, L.; Brumm, L.; Levy, M.; Gazit, E.; Oesterhelt, D. et al.; Baier, M.; Becker, C. F. W.; Engelhard, M.; Winklhofer, K. F.; Tatzelt, J.: Green tea extracts interfere with the stress-protective activity of PrPC and the formation of PrPSc. Journal of Neurochemistry 107 (1), pp. 218 - 229 (2008)
5.
Journal Article
Olschewski, D.; Seidel, R.; Miesbauer, M.; Rambold, A. S.; Oesterhelt, D.; Winklhofer, K. F.; Tatzelt, J.; Engelhard, M.; Becker, C. F. W.: Semisynthetic murine prion protein equipped with a GPI anchor mimic incorporates into cellular membranes. Chemistry & Biology 14 (9), pp. 994 - 1006 (2007)
6.
Journal Article
Miesbauer, M.; Bamme, T.; Riemer, C.; Oidtmann, B.; Winklhofer, K. F.; Baier, M.; Tatzelt, J.: Prion protein-related proteins from zebrafish are complex glycosylated and contain a glycosylphosphatidylinositol anchor. Biochemical and Biophysical Research Communications 341 (1), pp. 218 - 224 (2006)
7.
Journal Article
Dumpitak, C.; Beekes, M.; Weinmann, N.; Metzger, S.; Winklhofer, K. F.; Tatzelt, J.; Riesner, D.: The polysaccharide scaffold of PrP 27-30 is a common compound of natural prions and consists of alpha-linked polyglucose. Biological Chemistry 386 (11), pp. 1149 - 1155 (2005)
8.
Journal Article
Bertsch, U.; Winklhofer, K. F.; Hirschberger, T.; Bieschke, J.; Weber, P.; Hartl, F. U.; Tavan, P.; Tatzelt, J.; Kretzschmar, H. A.; Giese, A.: Single molecule analysis of protein aggregation and prions by SIFT. FEBS Journal 272 (Suppl. Suppl. 1), pp. 338 - 339 (2005)
9.
Journal Article
Bertsch, U.; Winklhofer, K. F.; Hirschberger, T.; Bieschke, J.; Weber, P.; Hartl, F. U.; Tavan, P.; Tatzelt, J.; Kretzschmar, H. A.; Giese, A.: Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets. Journal of Virology 79 (12), pp. 7785 - 7791 (2005)
10.
Journal Article
Kretzschmar, H. A.; Bertsch, U.; Winklhofer, K. F.; Hirschberger, T.; Bieschke, J.; Weber, P.; Hartl, F. U.; Tavan, P.; Tatzelt, J.; Giese, A.: Single molecule analysis of protein aggregation and prions by sift. Journal of Neuropathology and Experimental Neurology 64 (5), p. 441 - 441 (2005)
11.
Journal Article
Kiachopoulos, S.; Bracher, A.; Winklhofer, K. F.; Tatzelt, J.: Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor. Journal of Biological Chemistry 280 (10), pp. 9320 - 9329 (2005)
12.
Journal Article
Uelhoff, A.; Tatzelt, J.; Aguzzi, A.; Winklhofer, K. F.; Haass, C.: A pathogenic PrP mutation and Doppel interfere with polarized sorting of the prion protein. Journal of Biological Chemistry 280 (7), pp. 5137 - 5140 (2005)
13.
Journal Article
Henn, I. H.; Gostner, J. M.; Lackner, P.; Tatzelt, J.; Winklhofer, K. F.: Pathogenic mutations inactivate parkin by distinct mechanisms. Journal of Neurochemistry 92 (1), pp. 114 - 122 (2005)
14.
Journal Article
Tatzelt, J.; Winklhofer, K. F.: Folding and misfolding of the prion protein in the secretory pathway. Amyloid-Journal of Protein Folding Disorders 11 (3), pp. 162 - 172 (2004)
15.
Journal Article
Kiachopoulos, S.; Heske, J.; Tatzelt, J.; Winklhofer, K. F.: Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation. Traffic 5 (6), pp. 426 - 436 (2004)
16.
Journal Article
Heske, J.; Heller, U.; Winklhofer, K. F.; Tatzelt, J.: The C-terminal globular domain of the prion protein is necessary and sufficient for import into the endoplasmic reticulum. Journal of Biological Chemistry 279 (7), pp. 5435 - 5443 (2004)
17.
Journal Article
Winklhofer, K. F.; Henn, I. H.; Kay-Jackson, P. C.; Heller, U.; Tatzelt, J.: Inactivation of parkin by oxidative stress and C-terminal truncations - A protective role of molecular chaperones. Journal of Biological Chemistry 278 (47), pp. 47199 - 47208 (2003)
18.
Journal Article
Heller, U.; Winklhofer, K. F.; Heske, J.; Reintjes, A.; Tatzelt, J.: Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability - A critical role for the putative transmembrane domain. Journal of Biological Chemistry 278 (38), pp. 36139 - 36147 (2003)
19.
Journal Article
Brychzy, A.; Rein, T.; Winklhofer, K. F.; Hartl, F. U.; Young, J. C.; Obermann, W. M. J.: Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. EMBO Journal 22 (14), pp. 3613 - 3623 (2003)
20.
Journal Article
Winklhofer, K. F.; Heller, U.; Reintjes, A.; Tatzelt, J.: Inhibition of complex glycosylation increases the formation of PrPsc. Traffic 4 (5), pp. 313 - 322 (2003)
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