Publications of F. U. Hartl

Haacke, A.; Broadley, S. A.; Boteva, R.; Tzvetkov, N.; Hartl, F. U.; Breuer, P.: Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3. Human Molecular Genetics 15 (4), pp. 555 - 568 (2006)

Tomic, S.; Johnson, A. E.; Hartl, F. U.; Etchells, S. A.: Exploring the capacity of trigger factor to function as a shield for ribosome bound polypeptide chains. FEBS Letters 580 (1), pp. 72 - 76 (2006)

Grallath, S.; Schwarz, J. P.; Böttcher, U. M. K.; Bracher, A.; Hartl, F. U.; Siegers, K.: L25 functions as a conserved ribosomal docking site shared by nascent chain-associated complex and signal-recognition particle. EMBO Reports 7 (1), pp. 78 - 84 (2006)

Vabulas, R. M.; Hartl, F. U.: Protein synthesis upon acute nutrient restriction relies on proteasome function. Science 310 (5756), pp. 1960 - 1963 (2005)

Chang, H. C.; Kaiser, C. M.; Hartl, F. U.; Barral, J. M.: De novo folding of GFP fusion proteins: High efficiency in eukaryotes but not in bacteria. Journal of Molecular Biology 353 (2), pp. 397 - 409 (2005)

Stemp, M. J.; Guha, S.; Hartl, F. U.; Barral, J. M.: Efficient production of native actin upon translation in a bacterial lysate supplemented with the eukaryotic chaperonin TRiC. Biological Chemistry 386 (8), pp. 753 - 757 (2005)

Kerner, M. J.; Naylor, D. J.; Ishihama, Y.; Maier, T.; Chang, H. C.; Stines, A. P.; Georgopoulos, C.; Frishman, D.; Hayer-Hartl, M.; Mann, M. et al.; Hartl, F. U.: Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli. Cell 122 (2), pp. 209 - 220 (2005)

Bertsch, U.; Winklhofer, K. F.; Hirschberger, T.; Bieschke, J.; Weber, P.; Hartl, F. U.; Tavan, P.; Tatzelt, J.; Kretzschmar, H. A.; Giese, A.: Single molecule analysis of protein aggregation and prions by SIFT. FEBS Journal 272 (Suppl. Suppl. 1), pp. 338 - 339 (2005)

Bertsch, U.; Winklhofer, K. F.; Hirschberger, T.; Bieschke, J.; Weber, P.; Hartl, F. U.; Tavan, P.; Tatzelt, J.; Kretzschmar, H. A.; Giese, A.: Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets. Journal of Virology 79 (12), pp. 7785 - 7791 (2005)

Kretzschmar, H. A.; Bertsch, U.; Winklhofer, K. F.; Hirschberger, T.; Bieschke, J.; Weber, P.; Hartl, F. U.; Tavan, P.; Tatzelt, J.; Giese, A.: Single molecule analysis of protein aggregation and prions by sift. Journal of Neuropathology and Experimental Neurology 64 (5), p. 441 - 441 (2005)

Bracher, A.; Hartl, F. U.: Towards a complete structure of Hsp90. Structure 13 (4), pp. 501 - 502 (2005)

Shomura, Y.; Dragovic, Z.; Chang, H. C.; Tzvetkov, N.; Young, J. C.; Brodsky, J. L.; Guerriero, V.; Hartl, F. U.; Bracher, A.: Regulation of Hsp70 function by HspBP1: Structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange. Molecular Cell 17 (3), pp. 367 - 379 (2005)

Young, J. C.; Agashe, V. R.; Siegers, K.; Hartl, F. U.: Pathways of chaperone-mediated protein folding in the cytosol. Nature Reviews Molecular Cell Biology 5 (10), pp. 781 - 791 (2004)

Hartl, U.: Role of molecular chaperones in de novo protein folding and in misfolding disease. Protein Science 13 (Suppl. Suppl. 1), p. 67 - 67 (2004)

Schaffar, G.; Breuer, P.; Boteva, R.; Behrends, C.; Tzvetkov, N.; Strippel, N.; Sakahira, H.; Siegers, K.; Hayer-Hartl, M.; Hartl, F. U.: Cellular toxicity of polyglutamine expansion proteins: Mechanism of transcription factor deactivation. Molecular Cell 15 (1), pp. 95 - 105 (2004)

Etchells, S. A.; Hartl, F. U.: The dynamic tunnel. Nature Structural & Molecular Biology 11 (5), pp. 391 - 392 (2004)

Agashe, V. R.; Guha, S.; Chang, H. C.; Genevaux, P.; Hayer-Hartl, M.; Stemp, M.; Georgopoulos, C.; Hartl, F. U.; Barral, J. M.: Function of trigger factor and DnaK in multidomain protein folding: Increase in yield at the expense of folding speed. Cell 117 (2), pp. 199 - 209 (2004)

Wochnik, G. M.; Young, J. C.; Schmidt, U.; Holsboer, F.; Hartl, F. U.; Rein, T.: Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90. FEBS Letters 560 (1-3), pp. 35 - 38 (2004)

Barral, J. M.; Broadley, S. A.; Schaffar, G.; Hartl, F. U.: Roles of molecular chaperones in protein misfolding diseases. Seminars in Cell & Developmental Biology 15 (1), pp. 17 - 29 (2004)

Genevaux, P.; Keppel, F.; Schwager, F.; Langendijk-Genevaux, P. S.; Hartl, F. U.; Georgopoulos, C.: In vivo analysis of the overlapping functions of DnaK and trigger factor. EMBO Reports 5 (2), pp. 195 - 200 (2004)