Publications
Journal Publications
2020
Libicher K, Mutschler H. Probing self-regeneration of essential protein factors required for in vitro translation activity by serial transfer (2020), Chemical Communications, just accepted
Song EY, Jiménez EI, Lin H, Le Vay, K, Krishnamurthy R*, Mutschler H*. Prebiotically plausible RNA activation compatible with ribozyme‐catalyzed ligation (2020), Angewandte Chemie International Edition, just accepted
Donau C, Späth F, Sosson M, Kriebisch B, Schnitter F, Tena-Solsona M,Kang HS, Salibi E, Sattler M, Mutschler H, Job Boekhoven J. Active coacervate droplets as a model for membraneless organelles and protocells (2020), Nature Communications, 11, 5167
Le Vay K, Mutschler H, How DNA and RNA subunits might have formed to make the first genetic alphabet (2020), Nature, 582, 33-34
Libicher K, Hornberger R, Heymann M, Kriebisch B, Mutschler H. In vitro self-replication and multicistronic expression of large synthetic genomes (2020), Nature Communications, 11, 904
2019
Le Vay K*, Salibi E#, Song Y#, Mutschler H*. Nucleic acid catalysis under potential prebiotic conditions (2019), Chemistry—An Asian Journal, https://doi.org/10.1002/asia.201901205
*corresponding authors, #contributed equally
Mutschler H*, Robinson T*, Tang TYD*, Wegner S*. Special Issue on Bottom‐Up Synthetic Biology (2019), ChemBioChem, 20, 2533-2534
Weise LI, Heymann M, Mayr V, Mutschler H. Cell-free expression of RNA encoded genes using MS2 replicase (2019), Nucleic Acids Research, gkz817
Le Vay K and Mutschler H. The difficult case of an RNA-only origin of life (2019) Emerging Topics in Life Sciences, ETLS20190024
Morasch M, Liu J, Dirscherl C, Ianeselli A, Kühnlein A, Le Vay K, Schwintek P, Islam S, Corpinot M, Scheu B, Dingwell D, Schwille P, Mutschler H, Powner M, Mast C, and Braun D. Heated gas bubbles enrich, crystallize, dry, phosphorylate, and encapsulate prebiotic molecules (2019) Nature Chemistry, 11, 779-788
Le Vay K, Weise LI, Libicher K, Mascarenhas J, Mutschler H. Templated Self‐Replication in Biomimetic Systems (2019) Advanced BioSystems, 3, 1800313
2018
Mutschler H#*, Taylor AI*, Porebski BT, Lightowlers A, Houlihan G, Abramov M, Herdewijn P, Holliger P#. Random-sequence genetic oligomer pools display an innate potential for ligation and recombination (2018) eLife, 7:e43022
#corresponding authors, *joint first-authors
Drobot B, Iglesias-Artola JM*, Le Vay K*, Mayr V, Kar M, Kreysing M#, Mutschler H#, Tang TYD#. Compartmentalized RNA catalysis in membrane - free coacervate protocells (2018) Nature Communications, 9, 3643
#corresponding authors, *contributed equally
Weise LI, Libicher K, Mutschler H. Copy, paste, repeat – über die Synthese von Minimalzellen (2018) BIOspektrum, 4, 365-367.
Schwille P, Spatz J, Landfester K, Bodenschatz E, Herminghaus S, Sourjik V, Erb T, Bastiaens P, Lipowsky R, Hyman A, Dabrock P, Baret JC, Vidakovic-Koch T, Bieling P, Dimova R, Mutschler H, Robinson T, Tang D, Wegner S, Sundmacher K. MaxSynBio ‐ Avenues towards creating cells from the bottom up (2018) Angewandte Chemie International Edition, 130, 13566-13577
Litschel T, Ganzinger KA, Movinkel T, Heymann M, Robinson T, Mutschler H*, Schwille P*. Freeze-thaw cycles induce content exchange between cell-sized lipid vesicles (2018) New Journal of Physics, 20, 055008
*corresponding authors
before 2018
Cozens C*, Mutschler H*, Nelson GM, Houlihan G, Taylor AI, Holliger P. Enzymatic Synthesis of Nucleic Acids with Defined Regioisomeric 2′-5′ Linkages (2015) Angewandte Chemie International Edition, 54, 15570–15573
*joint first-author
Mutschler H, Wochner A, Holliger P. Freeze-thaw cycles as drivers of complex ribozyme assembly. (2015) Nature Chemistry, 7, 502–508
Mutschler H, Holliger P. Non-canonical 3'-5' extension of RNA with prebiotically plausible ribonucleoside 2', 3'-cyclic phosphates. (2014) Journal of the American Chemical Society, 136, 5193–5196.
Mutschler H, Meinhart A. ε/ζ systems: their role in resistance, virulence, and their potential for antibiotic development. (2011) Journal of Molecular Medicine, 89, 1183-1194.
Mutschler H, Gebhardt M, Shoeman RL, Meinhart A. A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis. (2011) PLoS Biology, 9, e1001033.
Lunde BM, Reichow SL, Kim M, Suh H, Leeper TC, Yang F, Mutschler H, Buratowski S, Meinhart A, Varani G. Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain. (2010) Nature Structural & Molecular Biology, 17, 1195-1201.
Mutschler H, Reinstein J, Meinhart A. Assembly dynamics and stability of the pneumococcal epsilon zeta antitoxin toxin (PezAT) system from Streptococcus pneumoniae. (2010) Journal of Biological Chemistry, 285, 21797-806.
Kress W, Mutschler H, Weber-Ban E. Both ATPase domains of ClpA are critical for processing of stable protein structures. (2009) Journal of Biological Chemistry, 284, 31441-52.
Vasiljeva L, Kim M*, Mutschler H*, Buratowski S, Meinhart A. The Nrd1-Nab3-Sen1 termination complex interacts with the Ser5-phosphorylated RNA polymerase II C-terminal domain. (2008) Nature Structural & Molecular Biology, 15, 795-804.
*contributed equally
Kress W, Mutschler H, Weber-Ban E. Assembly pathway of an AAA+ protein: tracking ClpA and ClpAP complex formation in real time. (2007) Biochemistry, 46, 6183-93.
Patents
Use of a new class of nucleotide sugar as antibiotic or cytostatic agent, Mutschler H, Meinhart A. WO Patent 2,012,038,097 (2012)
Book Chapters
Mutschler H, Meinhart A. Type II Toxin-Antitoxin Loci: The Epsilon/Zeta Family in: Prokaryotic Toxin-Antitoxins, 205-223. Springer Berlin Heidelberg (2013)