Gurumoorthy Krishnamoorthy

Gurumoorthy Krishnamoorthy

Research Group "Neuroinflammation and Mucosal Immunology"

Microbiome, Autoimmunity, Multiple Sclerosis, Immune Signaling

Up to 100 trillion microbes live in the human intestine. They are indispensable for health. However, changes in their relationship to the host have also been associated with diseases. Multiple sclerosis (MS) is one of these diseases, as Gurumoorthy Krishnamoorthy's work shows. With his research group "Neuroinflammation and Mucosal Immunology" he traces the responsible microbes. Using a specially developed transgenic MS mouse model, he was able to prove that these animals, which have an intact intestinal flora, show inflammatory reactions in the brain that are similar to those of multiple sclerosis in humans without external influences. In the following experiments on the mouse model, Krishnamoorthy's group was able to identify another important trigger: the cooperation of different cell types of the immune system.

Research Overview
Triggers of autoimmunity: a key role for gut flora, Regulation of autoimmunity and Transgenic models of nervous system autoimmunity more

Latest Research Highlights

High-salt diet suppresses autoimmune demyelination by regulating the blood–brain barrier permeability more
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