Autoimmune inflammation of the central nervous system (CNS) like in Multiple Sclerosis (MS), results from combined attack by self-reactive T and B lymphocytes which are natural components of the healthy immune repertoire. In most individuals, these lymphocytes remain innocuous throughout lifetime, but they can turn autoaggressive following pathogenic activation emanating from pathological presentation of the specific autoantigens and/or from innate immune responses against microbial structures. These processes seem to take place in peripheral tissues or in immune organs. Upon pathological conversion, activated lymphocytes overcome the blood brain barrier (BBB) and, with their pro-inflammatory cytokine profile, produce changes in the CNS tissue that ultimately translate into clinical disease.
In our research projects, by combining transgenic mouse models and cutting-edge technologies we approach questions of origin, development and regulation of CNS specific autoimmunity.
Latest publications from the lab
Mues, M., and Krishnamoorthy, G. (2018). BReDi mouse: A novel transgenic mouse strain to track and deplete B cells. Eur J Immunol. [In Press]
Berer, K., Martinez, I., Walker, A., Kunkel, B., Schmitt-Kopplin, P., Walter, J., Krishnamoorthy, G. Dietary non-fermentable fiber prevents autoimmune neurological disease by changing gut metabolic and immune status. Sci Rep 2018. 8, 10431.
Janakiraman, M & Krishnamoorthy, G. Emerging role of diet and microbiota interactions in neuroinflammation. Front Immunol 2018. 9,2067.
Spadaro, M., Winklmeier, S., Beltrán, E., Macrini, C., Höftberger, R., Schuh, E., Thaler Franziska, S., Gerdes, L.-A., Laurent, S., Gerhards, R., Brändle, S., Dornmair, K., Breithaupt, C., Krumbholz, M., Moser, M., Krishnamoorthy, G., Kamp, F., Jenne, D., Hohlfeld, R., Kümpfel, T., Lassmann, H., Kawakami, N., and Meinl, E.. Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein. Ann Neurol 2018 In Press.
Berer, K., Gerdes, L. A., Cekanaviciute, E., Jia, X., Xiao, L., Xia, Z., Liu, C., Klotz, L., Stauffer, U., Baranzini, S. E., Kümpfel, T., Hohlfeld, R., Krishnamoorthy, G*., Wekerle, H*. 2017. Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A. 114, 10719-10724. *Corresponding authors