Complexes that are associated to lipid membranes and transient macromolecular complexes carry out many important cellular functions, but their structures are largely elusive to date because these types of macromolecules are extremely difficult to assess by established reductionist approaches. We study such complexes in situ using cryo-electron microscopy techniques, protein-protein interactions, and computational modeling. Using this approach, we elucidate the molecular machinery that is associated to the endoplasmic reticulum (ER) and mitochondrial membranes. Specifically, we are interested in the structural basis of ER- and mitochondria-associated protein biogenesis and degradation.
Contact: Dr. Friedrich Förster
The lab participates in the DFG-funded graduate program GRK1721 Integrated Analysis of Macromolecular Complexes and Hybrid Methods in Genome Biology